Allergy, Asthma & Respiratory Disease

  • 제6권1호
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  • Pages.41-46
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  • 2018
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  • 2288-0402(pISSN)
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  • 2288-0410(eISSN)
대한천식알레르기학회 (The Korean Academy of Asthma, Allergy and Clinical Immunology)
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소아 비염 환자에서 혈청 비타민 D 및 interleukin-31 수치와 알레르기비염 및 비알레르기비염과의 관계

Relationship of serum vitamin D and interleukin-31 levels to allergic or nonallergic rhinitis in children

  • 박성준 (성균관대학교 의과대학 강북삼성병원 소아청소년과) ;
  • 소지은 (성균관대학교 의과대학 강북삼성병원 소아청소년과) ;
  • 박문수 (성균관대학교 의과대학 강북삼성병원 소아청소년과) ;
  • 정혜림 (성균관대학교 의과대학 강북삼성병원 소아청소년과) ;
  • 심재원 (성균관대학교 의과대학 강북삼성병원 소아청소년과) ;
  • 김덕수 (성균관대학교 의과대학 강북삼성병원 소아청소년과) ;
  • 심정연 (성균관대학교 의과대학 강북삼성병원 소아청소년과)
  • Park, Seong Jun (Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University of Medicine) ;
  • Soh, Ji Eun (Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University of Medicine) ;
  • Park, Moon Soo (Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University of Medicine) ;
  • Jung, Hye Lim (Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University of Medicine) ;
  • Shim, Jae Won (Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University of Medicine) ;
  • Kim, Deok Soo (Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University of Medicine) ;
  • Shim, Jung Yeon (Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University of Medicine)
  • 투고 : 2017.07.20
  • 심사 : 2017.11.02
  • 발행 : 2018.01.31
⟨ 이전 논문 다음 논문 ⟩

초록

Purpose: Serum vitamin D (25-hydroxyvitamin D, 25[OH] D) and interleukin-31 (IL-31) are related to atopic dermatitis, but their relationship with allergic rhinitis is unclear. The purpose of this study was to compare the levels of serum IL-31 and 25 (OH) D between the allergic rhinitis (AR), nonallergic rhinitis (NAR), and control groups and to investigate the relationship between IL-31 and 25 (OH) D. Methods: We recruited 59 children with only rhinitis and 33 controls without any allergic diseases. Serum IL-31 and 25(OH) D levels were assayed using an enzyme-linked immunosorbent assay and high-performance liquid chromatography, respectively. The patients were considered to have atopic sensitization if the levels of serum specific IgE to inhalant allergens as assessed using immunoCAP were ${\geq}0.35IU/mL$ or if they tested positive for one or more allergens by the skin prick test. Results: Of children with rhinitis, 25 had nonatopy (NAR), and 34 children had atopy (AR). Serum 25(OH) D levels were significantly lower in the rhinitis group than in the control group, while there was no significant difference serum 25(OH) D levels between the AR and NAR groups. Children with rhinitis demonstrated higher serum IL-31 levels than controls; however, there was no difference in serum IL-31 levels between the AR and NAR groups. Serum 25(OH) D levels were inversely correlated with serum IL-31 levels and blood eosinophil counts. On the other hand, serum 25(OH) D levels were not correlated with total serum IgE levels. Conclusion: Serum 25(OH) D and IL-31 may play a role in the pathogenesis of rhinitis via mechanisms other than IgE-related pathway.

키워드

참고문헌

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