The Journal of Pediatrics of Korean Medicine (대한한방소아과학회지)

The Association of Korean Oriental Pediatrics (대한한방소아과학회)
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A Review of Studies on Antibiotic Course and Antibiotic Resistance in Nasopharyngeal Pathogens in Primary Care Setting

일차진료 항생제 치료기간과 비인두 항생제 내성률에 대한 연구 고찰

  • Shin, Hyang Hwa (Pediatrics of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Lee, Sun Haeng (Pediatrics of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Yun, Sung Joong (Kyung Hee Jang Soo Korean Medicine Clinic) ;
  • Chang, Gyu Tae (Pediatrics of Clinical Korean Medicine, Graduate School, Kyung Hee University)
  • 신향화 (경희대학교 대학원 임상한의학과 소아과학교실) ;
  • 이선행 (경희대학교 대학원 임상한의학과 소아과학교실) ;
  • 윤성중 (경희장수한의원) ;
  • 장규태 (경희대학교 대학원 임상한의학과 소아과학교실)
  • Received : 2018.04.27
  • Accepted : 2018.05.21
  • Published : 2018.05.31
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Abstract

Objectives The purpose of this study is to examine the correlation of antibiotics administration duration and antimicrobial resistance by reviewing domestic and foreign literatures. Methods We searched literatures dated up to 23 February, 2018 in PubMed and Cochrane Library using terms of "Anti-Bacterial Agents", "Carrier State", "Nasopharynx", "Drug Administration Schedule", and also searched via RISS (Research Information Service System), KISS (Koreanstudies Information Service System), DBpia (DataBase Periodical Information Academic) using terms of antibiotics, resistance, and dose. Results In comparison with shortened and standard antibiotic course, longer treatment duration is associated with greater antimicrobial resistance or non-significant difference, but we cannot find literature that shortened antibiotic course increases antimicrobial resistance on human nasopharyngeal flora. Conclusions Currently, there is no evidence that completing the standard antibiotic course reduces antimicrobial resistance. It can be a strategy for reducing antibiotic use to apply Korean medicine treatment, as well as short-course antibiotic therapy or delayed antibiotic prescription. Additional well-designed trials should be conducted in domestic and foreign settings about the appropriate duration of antibiotic therapy.

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