Journal of the Korean Society of Radiology (대한영상의학회지)

The Korean Society of Radiology (대한영상의학회)
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Correlation of Semi-Quantitative Breast-Specific Gamma Imaging Findings with Dynamic Contrast-Enhanced MRI Parameters Assessed by a Computer-Aided Evaluation Program for Breast Cancer

유방암 환자에서 유방 특이 감마영상 검사의 반정량적 분석 및 유방 자기공명영상 검사의 컴퓨터보조진단 분석 결과의 비교 연구

  • Ahn, Saemee (Department of Radiology, Hanyang University College of Medicine) ;
  • Koo, Hye Ryoung (Department of Radiology, Hanyang University College of Medicine) ;
  • Park, Jeong Seon (Department of Radiology, Hanyang University College of Medicine) ;
  • Moon, Juhee (Department of Radiology, Hanyang University College of Medicine, Hanyang University Guri Hospital) ;
  • Choi, Yun Young (Department of Nuclear Medicine, Hanyang University College of Medicine) ;
  • Chung, Min Sung (Department of General Surgery, Hanyang University College of Medicine)
  • 안새미 (한양대학교 의과대학 영상의학교실) ;
  • 구혜령 (한양대학교 의과대학 영상의학교실) ;
  • 박정선 (한양대학교 의과대학 영상의학교실) ;
  • 문주희 (한양대학교 의과대학 구리병원 영상의학과) ;
  • 최윤영 (한양대학교 의과대학 핵의학교실) ;
  • 정민성 (한양대학교 의과대학 외과학교실)
  • Received : 2017.06.12
  • Accepted : 2017.09.29
  • Published : 2018.02.01
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Abstract

Purpose: To investigate whether a correlation exists between the semi-quantitative breast-specific gamma imaging (BSGI) findings and dynamic contrast-enhanced (DCE) MRI parameters assessed by a computer-aided evaluation program. Materials and Methods: Semi-quantitative index of the lesion to non-lesion (L/N) ratio in BSGI and DCE-MRI parameters was assessed by a computer-aided evaluation program, where 47 cases of invasive breast cancer were obtained. Correlations between the L/N ratio and DCE-MRI parameters were assessed by a computer-aided evaluation program. Tumor diameter (cm), angio-volume (cc), degree of initial peak enhancement (%), persistent enhancement proportion (%), and washout enhancement proportion (%) were analysed. The relationships between the L/N ratio and DCE-MRI parameters were evaluated by a univariate and multivariate regression analysis. Results: The mean L/N ratio of the 47 tumors was $3.63{\pm}2.19$ (range: 1-13.1). The L/N ratio was higher in tumors with larger diameters (p < 0.001), increased angiovolume (p < 0.001), higher degree of initial peak enhancement (p = 0.005) and increased washout enhancement proportion (p = 0.004). In the multivariate regression analysis, angio-volume (cc) and washout enhancement proportion (%) were associated with L/N ratio (p = 0.007 and p = 0.024, respectively). Conclusion: There was a correlation between the semi-quantitative L/N ratio in BSGI and DCE-MRI parameters assessed by a computer-aided evaluation program for breast cancer.

목적: 유방암 환자에 있어서 반정량적 유방 특이 감마영상 검사와 컴퓨터 보조진단 분석을 이용한 유방 자기공명영상 검사의 연관성을 보고자 하였다. 대상과 방법: 47명의 침습적 유방암 환자를 대상으로 유방 특이 감마영상 검사에서 병변과 비병변의 비(lesion to nonlesion raio; 이하 L/N ratio)와 역동적 조영증강 자기공명 매개변수의 연관성을 분석하였다. 역동성 조영증강 자기공명영상의 매개변수는 컴퓨터보조진단 분석을 통하여 병변의 크기(cm), 혈관조영 부피(angio-volume, cc), 초기 조영증강 정도(%), 지속적 조영증강 비율(%), 조영증강 감쇄 비율(%)의 항목을 분석하였다. 병변과 비병변의 비(L/N ratio)와 역동적 조영증강 자기공명 매개변수를 대상으로 단변량/다변량 회귀분석을 시행하였다. 결과: 47개의 종양의 유방 특이 감마영상 검사에서 병변/비병변의 비(L/N ratio)의 평균값은 $3.63{\pm}2.19$ (range: 1-13.1)였다. 병변/비병변의 비(L/N ratio)는 종양의 크기가 클수록(p < 0.001), 혈관조영 부피가 클수록(p < 0.001), 초기 조영증강 비율이 높을수록(p = 0.005), 조영증강 감쇄 비율이 높을수록(p = 0.004) 높게 나타났다. 다중회귀분석 결과, 혈관조영 부피(p = 0.007)와 조영증강 감쇄 비율(p = 0.024)이 유방 특이 감마영상 검사에서 병변/비병변의 비와 연관성을 보였다. 결론: 유방암 환자에서 컴퓨터보조진단 분석을 이용한 역동성 자기공명영상의 혈관조영 부피와 조영증강 감쇄 비율은 유방 특이 감마영상 검사에서의 병변/비병변의 비와 연관성을 가진다.

Keywords

Acknowledgement

Supported by : Hanyang University

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