Korean Circulation Journal

The Korean Society of Cardiology (대한심장학회)
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Association between Serum Parathyroid Hormone Levels and the Prevalence of Atrial Fibrillation: the Dong-gu Study

  • Lee, Ki Hong (Department of Cardiovascular Medicine, Chonnam National University Hospital) ;
  • Shin, Min-Ho (Department of Preventive Medicine, Chonnam National University Medical School) ;
  • Park, Hyung Wook (Department of Cardiovascular Medicine, Chonnam National University Hospital) ;
  • Cho, Jeong Gwan (Department of Cardiovascular Medicine, Chonnam National University Hospital) ;
  • Kweon, Sun-Seog (Department of Preventive Medicine, Chonnam National University Medical School) ;
  • Lee, Young-Hoon (Department of Preventive Medicine & Institute of Wonkwang Medical Science, Wonkwang University School of Medicine)
  • Received : 2017.08.17
  • Accepted : 2017.11.08
  • Published : 2018.02.28
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Abstract

Background and Objectives: We aimed to investigate the association between serum parathyroid hormone (PTH) levels and the prevalence of atrial fibrillation (AF) in a population based study. Methods: This study included a total of 9,007 community-dwelling Koreans aged 50 years and over who were enrolled in the Dong-gu study from 2007 to 2010. Electrocardiograms were recorded from the subjects using the HP-PageWriter 200 M1771A. All potential cases of AF were determined by 2 cardiologists. PTH concentration was measured by a chemiluminescent microparticle immunoassay. Multiple logistic regression analysis was used to evaluate the relationship between the quartiles of PTH and AF, adjusting for potential confounders. Results: The prevalence of AF was 2.41% in males and 0.9% in females and increased with advanced age in both genders. The median and interquartile range (IQR) of serum PTH was 39.5 pg/mL (IQR, 30.6-50.8), which was significantly higher in patients with AF than in patients without AF (p<0.001). The prevalence of AF increased with increasing PTH quartile (0.8%, 0.9%, 1.6%, and 2.8% in the lowest, second, third, and highest PTH quartiles, respectively; p<0.001). Multivariable logistic analysis adjusted for cardiovascular risk factors showed the highest quartile of serum PTH levels was associated with a higher prevalence of AF than the lowest quartile (odds ratio, 3.34; 95% confidence interval, 1.93-5.78). Conclusion: Higher levels of serum PTH were associated with higher prevalence of AF. Further studies are needed to determine whether this association is present in other populations and in a prospective study setting.

Keywords

References

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