Korean Circulation Journal

  • 제48권2호
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  • Pages.134-147
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  • 2018
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  • 1738-5520(pISSN)
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  • 1738-5555(eISSN)
대한심장학회 (The Korean Society of Cardiology)
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Long-term Prognosis and Clinical Characteristics of Patients with Newly Diagnosed Diabetes Mellitus Detected after First Acute Myocardial Infarction: from KAMIR-NIH Registry

  • Park, Hyun Woong (Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine) ;
  • Kang, Min Gyu (Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine) ;
  • Kim, Kyehwan (Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine) ;
  • Koh, Jin-Sin (Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine) ;
  • Park, Jeong Rang (Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine) ;
  • Jeong, Young-Hoon (Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Gyeongsang National University School of Medicine) ;
  • Ahn, Jong Hwa (Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Gyeongsang National University School of Medicine) ;
  • Jang, Jeong Yoon (Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Gyeongsang National University School of Medicine) ;
  • Kwak, Choong Hwan (Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Gyeongsang National University School of Medicine) ;
  • Park, Yongwhi (Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Gyeongsang National University School of Medicine) ;
  • Jeong, Myung Ho (Department of Internal Medicine, Chonnam National University Hospital) ;
  • Kim, Young Jo (Department of Internal Medicine, Yeungnam University Hospital) ;
  • Cho, Myeong Chan (Department of Internal Medicine, Chungbuk National University Hospital) ;
  • Kim, Chong Jin (Department of Internal Medicine, Kyung Hee University Hospital) ;
  • Hwang, Jin-Yong (Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine) ;
  • KAMIR-NIH registry (KAMIR-NIH registry)
  • 투고 : 2017.08.06
  • 심사 : 2017.12.13
  • 발행 : 2018.02.28
⟨ 이전 논문 다음 논문 ⟩

초록

Background and Objectives: After the first acute myocardial infarction (AMI), a considerable proportion of patients are newly diagnosed with diabetes mellitus (DM). However, in AMI, controversy remains regarding the disparity in prognosis between previously diagnosed DM (known-DM) and newly diagnosed DM (new-DM). Methods: The study included 10,455 patients with AMI (non-DM, 6,236; new-DM, 659; known-DM, 3,560) admitted to one of 15 participating centers in Korea between November 2011 and January 2016 (average follow-up, 523 days). We compared the characteristics and clinical course of patients with known-DM and those with new- or non-DM. Results: Compared to patients with known-DM, those with new-DM or non-DM were younger, more likely to be male, and less likely to have hypertension, dyslipidemia, prior stroke, angina, or myocardial infarction. Compared to patients with new-DM or non-DM (reference), those with known-DM had higher risks of major adverse cardiac events (hazard ratio [HR], 1.20; 95% confidence interval [CI], 1.06-1.35; p=0.004), cardiac death (HR, 1.26; 95% CI, 1.01-1.57; p=0.042), and congestive heart failure (HR, 1.58; 95% CI, 1.20-2.08). Unlike known-DM, new-DM did not increase the risk of cardiac events (including death). Conclusions: Known-DM was associated with a significantly higher risk of cardiovascular events after AMI, while new-DM had a similar risk of cardiac events as that noted for non-DM. There were different cardiovascular outcomes according to diabetes status in patients with AMI.

키워드

과제정보

연구 과제 주관 기관 : Korea Centers for Disease Control and Prevention

참고문헌

  1. National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 2002;106:3143-421.
  2. Rogers WJ, Frederick PD, Stoehr E, et al. Trends in presenting characteristics and hospital mortality among patients with ST elevation and non-ST elevation myocardial infarction in the National Registry of Myocardial Infarction from 1990 to 2006. Am Heart J 2008;156:1026-34. https://doi.org/10.1016/j.ahj.2008.07.030
  3. Wright RS, Anderson JL, Adams CD, et al. 2011 ACCF/AHA focused update of the guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction (updating the 2007 guideline): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines developed in collaboration with the American College of Emergency Physicians, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. J Am Coll Cardiol 2011;57:1920-59. https://doi.org/10.1016/j.jacc.2011.02.009
  4. Aguilar D, Solomon SD, Kober L, et al. Newly diagnosed and previously known diabetes mellitus and 1-year outcomes of acute myocardial infarction: the VALsartan In Acute myocardial iNfarcTion (VALIANT) trial. Circulation 2004;110:1572-8. https://doi.org/10.1161/01.CIR.0000142047.28024.F2
  5. Tian L, Wei C, Zhu J, et al. Newly diagnosed and previously known diabetes mellitus and short-term outcomes in patients with acute myocardial infarction. Coron Artery Dis 2013;24:669-75.
  6. Park HW, Yoon CH, Kang SH, et al. Early- and late-term clinical outcome and their predictors in patients with ST-segment elevation myocardial infarction and non-ST-segment elevation myocardial infarction. Int J Cardiol 2013;169:254-61. https://doi.org/10.1016/j.ijcard.2013.08.132
  7. Norhammar A, Malmberg K, Diderholm E, et al. Diabetes mellitus: the major risk factor in unstable coronary artery disease even after consideration of the extent of coronary artery disease and benefits of revascularization. J Am Coll Cardiol 2004;43:585-91. https://doi.org/10.1016/j.jacc.2003.08.050
  8. Ertelt K, Brener SJ, Mehran R, Ben-Yehuda O, McAndrew T, Stone GW. Comparison of outcomes and prognosis of patients with versus without newly diagnosed diabetes mellitus after primary percutaneous coronary intervention for ST-elevation myocardial infarction (the HORIZONS-AMI Study). Am J Cardiol 2017;119:1917-23. https://doi.org/10.1016/j.amjcard.2017.03.016
  9. Kim JH, Chae SC, Oh DJ, et al. Multicenter cohort study of acute myocardial infarction in Korea: interim analysis of the Korea acute myocardial infarction registry-national institutes of health registry. Circ J 2016;80:1427-36. https://doi.org/10.1253/circj.CJ-16-0061
  10. Thygesen K, Alpert JS, White HD Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction Universal definition of myocardial infarction. Eur Heart J 2007;28:2525-38. https://doi.org/10.1093/eurheartj/ehm355
  11. Smith SC Jr, Feldman TE, Hirshfeld JW Jr, et al. ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/SCAI Writing Committee to Update 2001 Guidelines for Percutaneous Coronary Intervention). Circulation 2006;113:e166-286. https://doi.org/10.1161/CIRCULATIONAHA.106.173220
  12. Stamler J, Vaccaro O, Neaton JD, Wentworth D. Diabetes, other risk factors, and 12-yr cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial. Diabetes Care 1993;16:434-44. https://doi.org/10.2337/diacare.16.2.434
  13. Haffner SM, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med 1998;339:229-34. https://doi.org/10.1056/NEJM199807233390404
  14. Mukamal KJ, Nesto RW, Cohen MC, et al. Impact of diabetes on long-term survival after acute myocardial infarction: comparability of risk with prior myocardial infarction. Diabetes Care 2001;24:1422-7. https://doi.org/10.2337/diacare.24.8.1422
  15. Vaccarino V, Parsons L, Every NR, Barron HV, Krumholz HM. Impact of history of diabetes mellitus on hospital mortality in men and women with first acute myocardial infarction. The National Registry of Myocardial Infarction 2 Participants. Am J Cardiol 2000;85:1486-9; A7. https://doi.org/10.1016/S0002-9149(00)00800-6
  16. Park KH, Ahn Y, Jeong MH, et al. Different impact of diabetes mellitus on in-hospital and 1-year mortality in patients with acute myocardial infarction who underwent successful percutaneous coronary intervention: results from the Korean Acute Myocardial Infarction Registry. Korean J Intern Med 2012;27:180-8. https://doi.org/10.3904/kjim.2012.27.2.180
  17. Beckman JA, Creager MA, Libby P. Diabetes and atherosclerosis: epidemiology, pathophysiology, and management. JAMA 2002;287:2570-81. https://doi.org/10.1001/jama.287.19.2570
  18. Creager MA, Lüscher TF, Cosentino F, Beckman JA. Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: Part I. Circulation 2003;108:1527-32. https://doi.org/10.1161/01.CIR.0000091257.27563.32
  19. Silva JA, Escobar A, Collins TJ, Ramee SR, White CJ. Unstable angina. A comparison of angioscopic findings between diabetic and nondiabetic patients. Circulation 1995;92:1731-6. https://doi.org/10.1161/01.CIR.92.7.1731
  20. Knobler H, Savion N, Shenkman B, Kotev-Emeth S, Varon D. Shear-induced platelet adhesion and aggregation on subendothelium are increased in diabetic patients. Thromb Res 1998;90:181-90. https://doi.org/10.1016/S0049-3848(98)00050-4
  21. Moreno PR, Murcia AM, Palacios IF, et al. Coronary composition and macrophage infiltration in atherectomy specimens from patients with diabetes mellitus. Circulation 2000;102:2180-4. https://doi.org/10.1161/01.CIR.102.18.2180
  22. Boudina S, Abel ED. Mitochondrial uncoupling: a key contributor to reduced cardiac efficiency in diabetes. Physiology (Bethesda) 2006;21:250-8.
  23. Aggarwal B, Shah G, Randhawa MS, Lincoff AM, Ellis SG, Menon V. Abstract 17910: patients with newly diagnosed diabetes have comparable long term mortality with known diabetics after ST segment elevation myocardial infarction. Circulation 2014;130:A17910.
  24. American Diabetes Association. (2) Classification and diagnosis of diabetes. Diabetes Care 2015;38 Suppl:S8-16.
  25. Tenerz A , Lonnberg I, Berne C, Nilsson G, Leppert J. Myocardial infarction and prevalence of diabetes mellitus. Is increased casual blood glucose at admission a reliable criterion for the diagnosis of diabetes? Eur Heart J 2001;22:1102-10. https://doi.org/10.1053/euhj.2000.2445
  26. Steg PG, Dabbous OH, Feldman LJ, et al. Determinants and prognostic impact of heart failure complicating acute coronary syndromes: observations from the Global Registry of Acute Coronary Events (GRACE). Circulation 2004;109:494-9. https://doi.org/10.1161/01.CIR.0000109691.16944.DA
  27. Eagle KA, Lim MJ, Dabbous OH, et al. A validated prediction model for all forms of acute coronary syndrome: estimating the risk of 6-month postdischarge death in an international registry. JAMA 2004;291:2727-33. https://doi.org/10.1001/jama.291.22.2727
  28. Kang SH, Suh JW, Choi DJ, et al. Cigarette smoking is paradoxically associated with low mortality risk after acute myocardial infarction. Nicotine Tob Res 2013;15:1230-8. https://doi.org/10.1093/ntr/nts248
  29. Fox CS, Sullivan L, D'Agostino RB Sr, Wilson PWFramingham Heart Study. The significant effect of diabetes duration on coronary heart disease mortality: the Framingham Heart Study. Diabetes Care 2004;27:704-8. https://doi.org/10.2337/diacare.27.3.704
  30. Lindsey JB, House JA, Kennedy KF, Marso SP. Diabetes duration is associated with increased thin-cap fibroatheroma detected by intravascular ultrasound with virtual histology. Circ Cardiovasc Interv 2009;2:543-8. https://doi.org/10.1161/CIRCINTERVENTIONS.109.876672

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