DOI QR코드

DOI QR Code

Diabetic Ketoacidosis Following Colonoscopy in Fulminant Type 1 Diabetes: A Case Report

전격성 제1형 당뇨병에서 대장내시경 후 발생한 당뇨병케톤산증 1예

  • Choi, Dug-Hyun (Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon Hospital) ;
  • Kim, Bo-Yeon (Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon Hospital) ;
  • Jung, Chan-Hee (Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon Hospital) ;
  • Kim, Chul-Hee (Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon Hospital) ;
  • Kang, Sung-Koo (Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon Hospital) ;
  • Mok, Ji-Oh (Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon Hospital)
  • 최덕현 (순천향대학교 의과대학 부천병원 내분비대사내과) ;
  • 김보연 (순천향대학교 의과대학 부천병원 내분비대사내과) ;
  • 정찬희 (순천향대학교 의과대학 부천병원 내분비대사내과) ;
  • 김철희 (순천향대학교 의과대학 부천병원 내분비대사내과) ;
  • 강성구 (순천향대학교 의과대학 부천병원 내분비대사내과) ;
  • 목지오 (순천향대학교 의과대학 부천병원 내분비대사내과)
  • Received : 2017.09.21
  • Accepted : 2018.01.22
  • Published : 2018.04.01

Abstract

Fulminant type 1 diabetes is a distinct subtype of type 1 diabetes mellitus that is characterized by sudden, complete destruction of pancreatic beta cells at the disease onset. Since the disease was first described in 2000 in Japan, a number of case reports have also been published in Korea. However, this disease entity is still not well defined. A 48-year old man with no medical history was admitted with diabetic ketoacidosis. Fulminant type 1 diabetes was diagnosed and he was discharged with multiple insulin injections. His serum glucose level was well controlled in the outpatient clinic. A month later, diabetic ketoacidosis occurred again following a diagnostic colonoscopy. This case suggests that fulminant type 1 diabetes is an aggressive disease in which small stimuli can provoke ketoacidosis. Therefore, for tests that require fasting, close observation by medical staff and patient education about the disease is essential.

저자들은 혈당조절이 원활하였으며 다른 유발 요인이 없던 전격성 제1형 당뇨병 환자에서, 진단적 대장내시경 검사 직후 당뇨병케톤산증이 발생한 증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

Keywords

References

  1. Imagawa A, Hanafusa T, Miyagawa J, Matsuzawa Y. A novel subtype of type 1 diabetes mellitus characterized by a rapid onset and an absence of diabetes-related antibodies. N Engl J Med 2000;342:301-307. https://doi.org/10.1056/NEJM200002033420501
  2. Imagawa A, Hanafusa T, Awata T, et al. Report of the Committee of the Japan Diabetes Society on the research of fulminant and acute-onset type 1 diabetes mellitus: new diagnostic criteria of fulminant type 1 diabetes mellitus (2012). J Diabetes Investig 2012;3:536-539. https://doi.org/10.1111/jdi.12024
  3. Jung TS, Chung SI, Kim MA, et al. A Korean patient with fulminant autoantibody-negative type 1 diabetes. Diabetes Care 2004;27:3023-3024. https://doi.org/10.2337/diacare.27.12.3023
  4. Imagawa A, Hanafusa T. Fulminant type 1 diabetes--an important subtype in East Asia. Diabetes Metab Res Rev 2011;27:959-964. https://doi.org/10.1002/dmrr.1236
  5. Kwak SH, Kim YJ, Chae J, et al. Association of HLA genotype and fulminant type 1 diabetes in Koreans. Genomics Inform 2015;13:126-131. https://doi.org/10.5808/GI.2015.13.4.126
  6. Imagawa A, Hanafusa T, Uchigata Y, et al. Fulminant type 1 diabetes: a nationwide survey in Japan. Diabetes Care 2003;26:2345-2352. https://doi.org/10.2337/diacare.26.8.2345
  7. Kim NH, Kim HY, Seo JA, et al. A pooled analysis of 29 patients with fulminant type 1 diabetes in Korea: a comparison with a nationwide survey in Japan. Diabetes Res Clin Pract 2009;86:e43-45. https://doi.org/10.1016/j.diabres.2009.09.003
  8. Ku YH. SGLT2 Inhibitors and ketoacidosis: pathophysiology and management. Korean J Med 2017;92:443-449. https://doi.org/10.3904/kjm.2017.92.5.443
  9. Kim W, Park SY, Kim MJ, Koo HM. Severe Hyponatremia with mental change after ingestion of picosulfate sodium/magnesium citrate for bowel preparation. Korean J Med 2016;91:206-210. https://doi.org/10.3904/kjm.2016.91.2.206
  10. Murase Y, Imagawa A, Hanafusa T, et al. Fulminant type 1 diabetes as a high risk group for diabetic microangiopathy--a nationwide 5-year-study in Japan. Diabetologia 2007;50:531-537. https://doi.org/10.1007/s00125-006-0575-y