The Korean journal of internal medicine

The Korean Association of Internal Medicine (대한내과학회)
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Effect of Helicobacter pylori eradication on the regression of gastric polyps in National Cancer Screening Program

  • Nam, Su Youn (Department of Gastroenterology, Center for Gastric Cancer, Kyungpook National University Medical Center) ;
  • Park, Bum Joon (Department of Internal Medicine, Center for Cancer Prevention & Detection, National Cancer Center) ;
  • Ryu, Kum Hei (Department of Internal Medicine, Center for Cancer Prevention & Detection, National Cancer Center) ;
  • Nam, Ji Hyung (Department of Internal Medicine, Center for Cancer Prevention & Detection, National Cancer Center)
  • Received : 2016.09.05
  • Accepted : 2016.11.01
  • Published : 2018.05.01
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Abstract

Background/Aims: Western guidelines recommend Helicobacter pylori eradication in H. pylori-associated gastric polyps; however, there is no standard guideline in Korea. The aim of this study is to assess the effect of H. pylori eradication on the regression of gastric hyperplastic polyps in National Cancer Screening Cohort, representative of general population. Methods: Among participants in National Cancer Screening Program, subjects who had H. pylori positive gastric hyperplastic polyps less than 10 mm and underwent follow-up endoscopy and H. pylori testing were enrolled. The effect of H. pylori eradication on hyperplastic gastric polyps was estimated using odds ratios (ORs) and 95% confidence intervals (CIs). Results: A total of 183 H. pylori infected subjects with hyperplastic polyp at baseline underwent follow-up endoscopy and H. pylori test after mean of 2.2 years. Successful H. pylori eradication markedly induced the disappearance of hyperplastic polyps comparing to non-eradication group (83.7% vs. 34.1%, p = 0.001). Successful eradication increased the possibility of disappearance of hyperplastic polyps (adjusted OR, 5.56; 95% CI, 2.63 to 11.11). Polyp size was inversely related with the disappearance of hyperplastic polyps (adjusted OR, 59; 95% CI, 0.48 to 0.71). Conclusions: Eradication of H. pylori infection may induce disappearance of gastric hyperplastic polyps in National Cancer Screening Cohort.

Keywords

References

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