Biomaterials Research (생체재료학회지)

Korean Society for Biomaterials (한국생체재료학회)
권호 표지
DOI QR코드

DOI QR Code

Analysis of trends and prospects regarding stents for human blood vessels

  • Lee, Jeong Hee (Graduate School of Health Science Business Convergence, College of Medicine, Chungbuk National University) ;
  • Kim, Eung Do (Graduate School of Health Science Business Convergence, College of Medicine, Chungbuk National University) ;
  • Jun, Eun Jung (Aurios Medical) ;
  • Yoo, Hyoung Sun (Korea Institute of Science and Technology Information) ;
  • Lee, Joon Woo (Korea Institute of Science and Technology Information)
  • Received : 2017.12.09
  • Accepted : 2018.02.12
  • Published : 2018.03.01
⟨ Previous Next ⟩

Abstract

Background: The purpose of this paper is to provide technology trends and information regarding market and prospects in stents used for human blood vessels in Korea and the world. A stent is a medical device in the form of a cylindrical metal net used to normalize flow when blood or other bodily fluids such as biliary fluids are obstructed in blood vessels, gastrointestinal tracts, etc. by inserting the stent into a narrowed or clogged area. Stents are classified into vascular and non-vascular stents. The coronary artery stent is avascular stent that is used for coronary atherosclerosis. The demand is increasing for stents to treat diseases such as those affecting the heart and blood vessels of elderly and middle-aged patients. Due to the current shift in the demographic structure caused by an aging society, the prospect for stents seems to be very bright. The use of a stent designed to prevent acute vascular occlusion and restenosis, which is a side effect of conventional balloon angioplasty, has rapidly become popular because it can prevent acute complications and improve clinical outcomes. Since the initial release of this stent, there have been significant developments in its design, the most notable of which has been the introduction of drug-eluting stents (DES). Bioresorbable scaffolds (BRS) have the potential to introduce a paradigm shift in interventional cardiology, a true anatomical and functional "vascular restoration" instead of an artificial stiff tube encased by a persistent metallic foreign body. Methods: Data for this research were gathered from primary and secondary sources as well as the databases of the Korea Institute of Science Technology Information (KISTI) located in Seoul, Korea like KISTI Market Report. The sources used for primary research included the databases available from the Korea Institute of Science Technology Information, past industry research services/studies, economic and demographic data, and trade and industry journals. Secondary research was used to supplement and complement the primary research. Interviews were conducted with physicians and surgeons from the key hospitals and senior sale/marketing managers from stent product suppliers in South Korea. Results: The global stent market is estimated at US $ 7.98 billion in 2016 and is expected to grow at a Compound Annual Growth Rate (CAGR) of 3.8% over the next 5 years. As of 2016, the global market for vascular stents is estimated at $ 7.22 billion, with coronary artery stents accounting for 67.3% of the vascular stent market. Among the coronary artery stents, BRS is notably expected to grow at an annual average rate of 8.8% by 2020, but the global adoption rate of BRS remains low at present. In the Korean market, stents for blood vessels account for most of the market, and the market size of stents for blood vessels in Korea was estimated to be 145 billion won as of 2016. Conclusions: In comparison to the sales growth rate of other medical devices, the future stent technology market is judged to be higher in growth potential.

Keywords

Acknowledgement

Supported by : Korea Institute of Science and Technology Information (KISTI)

References

  1. Human implantable medical device - Stent, KISTI market report, 2016.
  2. Stent, KISTI business opportunity supporting system, 2016.
  3. Garg S, Serruys PW. Coronary stents-current status. J Am Coll Cardiol. 2010;56(10):S1-S42. https://doi.org/10.1016/j.jacc.2010.06.007
  4. Shin E-S.Current status of coronary stent. Korean J Med. 2015;89:282-90. https://doi.org/10.3904/kjm.2015.89.3.282
  5. Garg S, Serruys PW. Coronary stents-looking forward. J Am Coll Cardiol. 2010;56(10):S43-78. https://doi.org/10.1016/j.jacc.2010.06.008
  6. Ormiston JA, Serruys PW, Regar E, et al. A bioabsorbable everolimus-eluting coronary stent system for patients with single de-novo coronary artery lesions (ABSORB): a prospective open-label trial. Lancet. 2008;371(9616):899-907. https://doi.org/10.1016/S0140-6736(08)60415-8
  7. Serruys PW, Ormiston JA, Onuma Y, et al. A bioabsorbable everolimuseluting coronary stent system (ABSORB): 2-year outcomes and results from multiple imaging methods. Lancet. 2009;373(9667):897-910. https://doi.org/10.1016/S0140-6736(09)60325-1
  8. Serruys PW, Garcia-Garcia HM, Onuma Y. From metallic cages to transient bioresorbable scaffolds: change in paradigm of coronary revascularization in the upcoming decade. Eur Heart J. 2012;33(1):16-25b. https://doi.org/10.1093/eurheartj/ehr384
  9. Caiazzo G, Kilic ID, Fabris E, Serdoz R, Mattesini A, Foin N, De Rosa S, Indolfi C, Di Mario C. Absorb bioresorbable vascular scaffold: what have we learned after 5 years of clinical experience? Int J Cardiol. 2015;201:129-36. https://doi.org/10.1016/j.ijcard.2015.07.101
  10. Lee JH, Yoo HS, Seo J. Drug-releasing biodegradable stent, Technical Valuation Report, KISTI. October 2016. p. 1-102.
  11. Stent, KhIDI Brief. Korea Health Industry Development Institute (KhIDI), vol. 52; 2017.
  12. S-J Kim, J-G Park, JH Kim, IK Kwon, An Overview of Researches Trend in Drug-Eluting Stents Development. Biomater Res. 2010;14(1):37-49.
  13. Brie D, et al. Bioresorbable scaffold - a magic bullet for the treatment of coronary artery disease? Int J Cardiol. 2016;215:47-59. https://doi.org/10.1016/j.ijcard.2016.04.027
  14. Onuma Y, Serruys PW. Bioresorbable scaffold: the advent of a new era in percutaneous coronary and peripheral revascularization? Circulation. 2011;123(7):779-97. https://doi.org/10.1161/CIRCULATIONAHA.110.971606
  15. WIPS. Bio, Technology Roadmap for SME 2017-2019, Korea Minstry of SME. 2016. p. 1-334.
  16. Long-term Technology Roadmap Planning to Overcome Cardio-Cerebrovascular Disease, Korea centers for disease control and prevention, 2012.
  17. Choi C, Nah J-W, Park J-K. Development trends of the stent for coronary artery. KIC News. 2015;18:10-24.
  18. Ang HY, et al. Bioresorbable stents: current and upcoming bioresorbable technologies. Int J Cardiol. 2017;228:931-9. https://doi.org/10.1016/j.ijcard.2016.11.258
  19. Wiemer, et al. Third generation drug eluting stent (DES) with biodegradable polymer in diabetic patients: 5 years follow-up. Cardiovasc Diabetol. 2017;16:23. https://doi.org/10.1186/s12933-017-0500-3
  20. ICT Patent Disputes and Patent Trends Related to the Fourth Industrial Revolution, Weekly Technology Trends, Institute for information & communications technology promotion, 2017.
  21. 2017 Healthcare Outlook, Hanyang securities research center, 2016.
  22. Stent Technology Trend, Korea health industry development institute, 2014.

Cited by

  1. The effect of surface wettability on induction and growth of neurites from the PC-12 cell on a polymer surface vol.259, pp.2, 2003, https://doi.org/10.1016/s0021-9797(02)00163-7
  2. The number of stents was an independent risk of stent restenosis in patients undergoing percutaneous coronary intervention vol.98, pp.50, 2018, https://doi.org/10.1097/md.0000000000018312
  3. The Future of Cardiovascular Stents: Bioresorbable and Integrated Biosensor Technology vol.6, pp.20, 2019, https://doi.org/10.1002/advs.201900856
  4. The Impact of Coexistence of Smoking and Diabetes on the Coronary Artery Severity and Outcomes following Percutaneous Coronary Intervention: Results from the 1 ST Jordanian PCI Registry vol.2020, pp.None, 2020, https://doi.org/10.1155/2020/7624158
  5. Effects of different polyaniline emeraldine compositions in electrodepositing ginsenoside encapsulated poly(lactic‐co‐glycolic acid) microcapsules coating: Physicochemical characterization vol.108, pp.5, 2020, https://doi.org/10.1002/jbm.a.36891
  6. Some Perspectives on Hypersensitivity to Coronary Stents vol.14, pp.None, 2021, https://doi.org/10.2147/ijgm.s326679
  7. TESTING PASSIVE VERSUS SYMMETRIC BELIEFS IN CONTRACTING WITH EXTERNALITIES vol.62, pp.2, 2021, https://doi.org/10.1111/iere.12492
  8. Gene Polymorphisms of the Renin-Angiotensin-Aldosterone System as Risk Factors for the Development of In-Stent Restenosis in Patients with Stable Coronary Artery Disease vol.11, pp.5, 2018, https://doi.org/10.3390/biom11050763