The Journal of Korean Obstetrics and Gynecology (대한한방부인과학회지)

The Society of Korean Medicine Obstetrics and Gynecology (대한한방부인과학회)
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Effects of Artemisiae Annuae Herba (AAH) on Cell Death of Ovarian Cancer in Vivo and in Vitro Study

개똥쑥이 난소암 세포의 사멸에 미치는 영향

  • Seo, Kook-Jang (Dept. of OB & GY, College of Korean Medicine, Dong-Shin University) ;
  • Cho, Seong-Hee (Dept. of OB & GY, College of Korean Medicine, Dong-Shin University) ;
  • Yang, Seung-Jung (Dept. of OB & GY, College of Korean Medicine, Dong-Shin University) ;
  • Park, Kyung-Mi (Dept. of OB & GY, College of Korean Medicine, Dong-Shin University)
  • 서국장 (동신대학교 한의과대학 부인과학교실) ;
  • 조성희 (동신대학교 한의과대학 부인과학교실) ;
  • 양승정 (동신대학교 한의과대학 부인과학교실) ;
  • 박경미 (동신대학교 한의과대학 부인과학교실)
  • Received : 2018.04.26
  • Accepted : 2018.03.16
  • Published : 2018.05.25
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Abstract

Objective: This study was designed to investigate the anti-cancer effects of AAH on ovarian cancer in vitro and by using allograft model in vivo. Methods: In this experiment, the effects of AAH on proliferation rates, cell morphology, cell death type, cell cycle, caspase activities and p38 mitogen-activated protein kinase (MAPK) pathway were investigated in A2780, human ovarian cell line. Results: AAH inhibited proliferation of A2780 cells in a dose dependent manner. In addition, AAH induced apoptosis but did not affect cell cycle of A2780 cells. AAH also effectively inhibited caspase 3 and caspase 9 activities respectively. In allograft tumor model, AAH reduced tumor volume and expanded life span in a dose dependent manner. Conclusion: It can be inferred that AAH can induce apoptosis in ovarian cancer cells and has possibility as an anticancer agent for ovarian cancer.

Keywords

References

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