치위생과학회지 (Journal of dental hygiene science)

  • 제18권2호
  • /
  • Pages.130-135
  • /
  • 2018
  • /
  • 1598-4478(pISSN)
  • /
  • 2233-7679(eISSN)
한국치위생과학회 (The Korean Society of Dental Hygiene Science)
권호 표지
DOI QR코드

DOI QR Code

수학적 모델링을 이용한 골조직 세포 네트워크에서 Osteal Macrophage와 골세포의 역할 예측

Predicting the Role of Osteal Macrophages and Osteocytes in Bone Tissue Network Using a Mathematical Modeling

  • 황수정 (건양대학교 의과학대학 치위생학과)
  • Hwang, Soo-Jeong (Department of Dental Hygiene, College of Medical Science, Konyang University)
  • 투고 : 2018.03.29
  • 심사 : 2018.04.12
  • 발행 : 2018.04.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

본 연구는 osteomac과 골세포가 골조직 개조과정에서 하는 역할을 조사하고자 수학적 모델링 방법을 사용하였다. 2013년에 발표된 Graham's model을 기반으로 하고 osteomac을 해당 네트워크에 추가하여 각 링크의 파라미터와 상미분방정식을 작성하였다. 컴퓨터 시뮬레이션 결과 osteomac과 골세포의 효율성이 일정 수치 이하인 경우 골조직 개조가 안정적이지 않고 감소하는 방향으로 이동하였다. 골세포의 효율성은 일정 수치 이상이 되어야 골조직 개조에도 골량이 유지되었으며 osteomac의 효율성의 수치가 증가함에 따라 골량도 함께 증가하는 것을 볼 수 있었다. Osteomac의 효율성이 골조직 개조와 골량 유지에 많은 영향을 미칠 수 있음을 제안한다.

The aim of this study was to investigate the role of osteal macrophages (osteomac) and osteocytes in bone remodeling using a mathematical model. We constructed the bone system with pre-osteoblasts, osteoclasts, osteocytes, and osteomac. Each link of the parameters and ordinary differential equations followed the Graham's model in 2013 except for the parameters of osteomac signaling and osteocytes signaling to link preosteoblasts and osteoblasts. We simulated the changes in each cell and bone volume according to the changes in the parameters of osteomac signaling and osteocytes signaling. The results showed bone volume was unstable and decreased gradually when the effectiveness of osteocytes and osteomac dropped below a certain level. When the parameters of osteomac signaling and osteocytes signaling to link preosteoblasts and osteoblasts had a value less than 1, bone volume increased with the increase in the parameter of osteomac signaling to link preosteoblasts and osteoblasts. Moreover, although the parameter of osteocytes signaling to link preosteoblasts and osteoblasts, increased in case of a small parameter of osteomac signaling, bone volulme decreased. If the parameters of osteomac signaling to link preosteoblasts and osteoblasts were over a certain level, bone volume was positively maintained, despite the parameter of osteocyte signaling to link preosteoblasts and osteoblasts. We suggested the osteomac may affect bone remodeling and may play an important role in bone cell network.

키워드

참고문헌

  1. Breitling R: What is systems biology? Front Physiol 1: 9, 2010. https://doi.org/10.3389/fphys.2010.00009
  2. Kitano H: Systems biology: a brief overview. Science 295: 1662-1664, 2002. https://doi.org/10.1126/science.1069492
  3. Hsu YH, Niu T, Terwedow HA, et al.: Variation in genes involved in the RANKL/RANK/OPG bone remodeling pathway are associated with bone mineral density at different skeletal sites in men. Hum Genet 118: 568-577, 2006. https://doi.org/10.1007/s00439-005-0062-4
  4. Lamora A, Talbot J, Mullard M, Brounais-Le Royer B, Renidi F, Verrecchia F: TGF-${\beta}$ signaling in bone remodeling and osteosarcoma progression. J Clin Med 5: E96, 2016. https://doi.org/10.3390/jcm5110096
  5. Poon B, Kha T, Tran S, Dass CR: Bone morphogenetic protein-2 and bone therapy: successes and pitfalls. J Pharm Pharmacol 68: 139-147, 2016. https://doi.org/10.1111/jphp.12506
  6. Karner CM, Long F: Wnt signaling and cellular metabolism in osteoblasts. Cell Mol Life Sci 74: 1649-1657, 2017. https://doi.org/10.1007/s00018-016-2425-5
  7. Zhao B: TNF and bone remodeling. Curr Osteoporos Rep 15: 126-134, 2017. https://doi.org/10.1007/s11914-017-0358-z
  8. Ruscitti P, Cipriani P, Carubbi F, et al.: The role of IL-1${\beta}$ in the bone loss during rheumatic diseases. Mediators Inflamm 2015: 782382, 2015. https://doi.org/10.1155/2015/782382
  9. Prideaux M, Findlay DM, Atkins GJ: Osteocytes: the master cells in bone remodelling. Curr Opin Pharmacol 28: 24-30, 2016. https://doi.org/10.1016/j.coph.2016.02.003
  10. Miron RJ, Bosshardt DD: OsteoMacs: key players around bone biomaterials. Biomaterials 82: 1-19, 2016. https://doi.org/10.1016/j.biomaterials.2015.12.017.
  11. Graham JM, Ayati BP, Holstein SA, Martin JA: The role of osteocytes in targeted bone remodeling: a mathematical model. PLoS One 8: e63884, 2013. https://doi.org/10.1371/journal.pone.0063884
  12. Raggatt LJ, Partridge NC: Cellular and molecular mechanisms of bone remodeling. J Biol Chem 285: 25103-25108, 2010. https://doi.org/10.1074/jbc.R109.041087
  13. Teitelbaum SL, Tondravi MM, Ross FP: Osteoclasts, macrophage, and the molecular mechanisms of bone resorption. J Leukoc Biol 61: 381-388, 1997. https://doi.org/10.1002/jlb.61.4.381
  14. Komarova SV, Smith RJ, Dixon SJ, Sims SM, Wahl LM: Mathematical model predicts a critical role for osteoclast autocrine regulation in the control of bone remodeling. Bone 33: 206-215, 2003. https://doi.org/10.1016/S8756-3282(03)00157-1
  15. Ayati BP, Edwards CM, Webb GF, Wikswo JP: A mathematical model of bone remodeling dynamics for normal bone cell populations and myeloma bone disease. Biol Direct 5: 28, 2010. https://doi.org/10.1186/1745-6150-5-28
  16. Lemaire V, Tobin FL, Greller LD, Cho CR, Suva LJ: Modeling the interactions between osteoblast and osteoclast activities in bone remodeling. J Theor Biol 229: 293-309, 2004. https://doi.org/10.1016/j.jtbi.2004.03.023
  17. Pivonka P, Zimak J, Smith DW, et al.: Theoretical investigation of the role of the RANK-RANKL-OPG system in bone remodeling. J Theor Biol 262: 306-316, 2010. https://doi.org/10.1016/j.jtbi.2009.09.021
  18. Sun X, Su J, Bao J, et al.: Cytokine combination therapy prediction for bone remodeling in tissue engineering based on the intracellular signaling pathway. Biomaterials 33: 8265-8276, 2012. https://doi.org/10.1016/j.biomaterials.2012.07.041
  19. Sabokbar A, Fujikawa Y, Neale S, Murray DW, Athanasou NA: Human arthroplasty derived macrophage differentiate into osteoclast bone resorbing cells. Ann Rheum Dis 56: 414-420, 1997. http://dx.doi.org/10.1136/ard.56.7.414
  20. Fujikawa Y, Sabokbar A, Neale S, Athanasou NA: Human osteoclast formation and bone resorption by monocytes and synovial macrophages in rheumatoid arthritis. Ann Rheum Dis 55: 816-822, 1996. http://dx.doi.org/10.1136/ard.55.11.816
  21. Chang MK, Raggatt LJ, Alexander KA, et al.: Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and in vivo. J Immunol 181: 1232-1244, 2008. https://doi.org/10.4049/jimmunol.181.2.1232