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Structural damage to periodontal tissues at varying rate of anesthetic injection

  • Received : 2018.01.17
  • Accepted : 2018.02.22
  • Published : 2018.04.30

Abstract

Background: Incorrect administration of an anesthetic during local anesthesia is one of the most important causes of pain symptoms in patients scheduled for dental procedures. The current study assessed the severity of damage to periodontal tissue following different rates of anesthetic administration. Methods: The research was conducted on 50 outbred male rats with a body mass of 180-240 g. The anesthetic used was 1% articaine. Results: The results showed that administration of the anesthetic at a rapid pace caused structural damage to the periodontal tissue. Further, signs of impaired microcirculation were noted at all rates of administration. Biochemical studies demonstrated changes in the level of glucose and enzymes with the rapid introduction of the anesthetic, indicating severe systemic stress response of the body. Conclusions: Injection of local anesthetic at any rate of introduction induces vascular congestion in the microcirculatory bloodstream and exudative reactions. Rapid introduction of an anesthetic causes progression of structural changes in the gingival tissue.

Keywords

References

  1. Milgrom P, Coldwell SE, Getz T, Weinstein P, Ramsay DS. Four dimensions of fear of dental injections. J Am Dent Assoc 1997; 128: 756-62. https://doi.org/10.14219/jada.archive.1997.0301
  2. Abrahamsson KH, Berggren U, Hallberg L, Carlsson SG. Dental phobic patients' view of dental anxiety and experiences in dental care: a qualitative study. Scand J Caring Sci 2002; 16: 188-96. https://doi.org/10.1046/j.1471-6712.2002.00083.x
  3. Weinstein P, Shimono T, Domoto P, Wohlers K, Matsumura S, Ohmura M, et al. Dental fear in Japan: Okayama Prefecture school study of adolescents and adults. Anesth Prog 1992; 39: 215-20.
  4. Tzafalia M, Sixou JL. Administration of anesthetic solutions using a metal syringes. An ex vivo study. Anesth Prog 2011; 58: 61-5. https://doi.org/10.2344/0003-3006-58.2.61
  5. Saijo M, Ito E, Ichinohe T, Kaneko Y. Lack of pain reduction by a vibrating local anesthetic attachment: a pilot study. Anesth Prog 2005; 52: 62-4. https://doi.org/10.2344/0003-3006(2005)52[62:LOPRBA]2.0.CO;2
  6. Jacobs S, Haas DA, Meechan JG, May S. Injection pain: comparison of the three mandibular block techniques and modulation by nitrous oxide. J Am Dent Assoc 2003; 134: 869-76. https://doi.org/10.14219/jada.archive.2003.0285
  7. Flanagan T, Wahl MJ, Schmitt MM, Wahl JA. Size doesn't matter: needle gauge and injection pain. Gen Dent 2007; 55: 216-7.
  8. Meechan JG, Howlett PC, Smith BD. Factors influencing the discomfort of intraoral needle penetration. Anesth Prog 2005; 52: 91-4. https://doi.org/10.2344/0003-3006(2005)52[91:FITDOI]2.0.CO;2
  9. Nakanishi O, Haas D, Ishikawa T, Kameyama S, Nishi M. Efficacy of mandibular topical anesthesia varies with the site of administration. Anesth Prog 1996; 43: 14-9.
  10. Kaufman E, Epstein JB, Naveh E, Gorsky M, Gross A, Cohen G. A survey of pain, pressure, and discomfort induced by commonly used oral local anesthesia injections. Anesth Prog 2005; 52: 122-7. https://doi.org/10.2344/0003-3006(2005)52[122:ASP]2.0.CO;2
  11. Meechan JG. Pain control in local analgesia. Eur Arch Paediatr Dent 2009; 10: 71-6. https://doi.org/10.1007/BF03321603
  12. Primosch RE, Brooks R. Influence of anesthetic flow rate delivered by the Wand Local Anesthetic System on pain response to palatal injections. Am J Dent 2002; 15: 15-20.
  13. Kudo M. Initial injection pressure for dental local anesthesia: effects on pain and anxiety . Anesth Prog 2005; 52: 95-101. https://doi.org/10.2344/0003-3006(2005)52[95:IIPFDL]2.0.CO;2
  14. Pashley EL, Nelson R, Pashley DH. Pressures created by dental injections. J Dent Res 1981; 60: 1742-8. https://doi.org/10.1177/00220345810600100301
  15. Sumer M, Misir F, Koyuturk AE. Comparison of the Wand with a conventional technique. Oral Surg Oral Pathol Oral Radiol Endod 2006; 101: e106-9. https://doi.org/10.1016/j.tripleo.2005.12.002
  16. Versloot J, Veerkamp JS, Hoogstraten J. Computerized anesthesia delivery system vs. traditional syringe: comparing pain and pain-related behavior in children. Eur J Oral Sci 2005; 113: 488-93. https://doi.org/10.1111/j.1600-0722.2005.00252.x
  17. Meechan JG. Differences between men and women regarding attitudes toward dental local anesthesia among junior students at a United Kingdom dental school. Anesth Prog 2005; 52: 50-5. https://doi.org/10.2344/0003-3006(2005)52[50:DBMAWR]2.0.CO;2
  18. Rankin JA, Harris MB. Comparison of stress and coping in male and female dentists. J Dent Pract Adm 1990; 7: 166-72.
  19. Hochman MN, Friedman MJ, Williams W, Hochman CB. Interstitial tissue pressure associated with dental injections: a clinical study. Quintessence Int 2006; 37: 469-76.
  20. Walmsley AD, Lloyd JM, Harrington E. Pressures produced in vitro during intraligamentary anaesthesia. Br Dent J 1989; 167: 341-4. https://doi.org/10.1038/sj.bdj.4807030
  21. J. Derrell Clark Gerald F. Gebhart Janet C. Gonder Michale E. Keeling Dennis F. Kohn. The 1996 Guide for the care and use of laboratory animals. ILAR Journal 1997; 38:41-8. https://doi.org/10.1093/ilar.38.1.41
  22. Flecknell PA. Laboratory animal anesthesia. London: Academic Press; 1987.
  23. Swindle MM, Adams RJ. Experimental surgery and physiology: induced animal models of human disease. Baltimore, Williams & Wilkins. 1988.
  24. Baart JA, Brand HS. Local Anaesthesia in Dentistry In: Microprocessor-Aided Local Anaesthesia. 2Ed. Springer International Publishing. 2017, pp 113-23.
  25. Lillie RD. HJ Conn's Biological Stains, 4th ed. Baltimore, Williams and Wilkins. 1977.
  26. Bancroft JD, Stevens A. Theory and Practice of Histological Techniques, 4th ed. New York, Churchill Livingstone. 1996.
  27. Pratt DS, Kaplan MM. Evaluation of abnormal liver enzyme results in asymptomatic patients. N Engl J Med 2000; 342: 1266-71. https://doi.org/10.1056/NEJM200004273421707
  28. De Ritis F, Coltorti M, Giusti G. An enzymic test for the diagnosis of viral hepatitis: the transaminase serum activities. 1957. Clin Chim Acta 2006; 369: 148-52. https://doi.org/10.1016/j.cca.2006.05.001
  29. Selye H. Stress in health and disease. Boston, Butterworths. 1976.
  30. Cioffi GA, Chernow B, Glahn RP, Terezhalmy GT, Lake CR. The hemodynamic and plasma catecholamine responses to routine restorative dental care. J Am Dent Assoc 1985; 111: 67-70. https://doi.org/10.14219/jada.archive.1985.0038
  31. Jastak JT, Yagiela JA. Vasoconstrictors and local anesthesia: a review and rationale for use. J Am Dent Assoc 1983; 107: 623-30. https://doi.org/10.14219/jada.archive.1983.0307
  32. American Gastroenterological Association medical position statement: evaluation of liver chemistry tests. Gastroenterology 2002; 123: 1364-6. https://doi.org/10.1053/gast.2002.36060
  33. Selye H. The story of the adaptation syndrome. Am J Med Sci 1952; 224: 711.
  34. Grizuk SF. Oral and Maxillofacial Surgery. Moscow, Geotar-Media. 2010. [In Russian].
  35. Sisk AL. Vasoconstrictors in local anesthesia for dentistry. Anesth Prog 1992; 39: 187-193.
  36. Ibragimov ZI, Semkin VA, Didikin SS, Titova GP. Features of the morphological changes of skeletal muscles after intramuscular administration of anesthetics. Alfavit stomatologii 2007; 1: 42-4. [In Russian].
  37. Zoryan EV, Rabinovich SA. Vasoconstrictive agents in composition of local anesthetics: significance and problems. Clin Dent 2006; 3: 24-8. [In Russian].
  38. Rabinovich SA., Kuznetzov GI, Moscowez ON, Zoryan EV. Int Dent Rev 2008; 1: 14-5. [In Russian].