Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
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Association between vitamin D and urinary tract infection in children

  • Mahyar, Abolfazl (Qazvin Children Hospital, Qazvin University of Medical Sciences) ;
  • Ayazi, Parviz (Qazvin Children Hospital, Qazvin University of Medical Sciences) ;
  • Safari, Sara (Qazvin Children Hospital, Qazvin University of Medical Sciences) ;
  • Dalirani, Reza (Mofid Children Hospital, Pediatric Nephrology Department, Shahid Beheshti University of Medical Sciences) ;
  • Javadi, Amir (Statistic Department, Qazvin University of Medical Sciences) ;
  • Esmaeily, Shiva (Statistic Department, Qazvin University of Medical Sciences)
  • Received : 2017.09.14
  • Accepted : 2017.12.29
  • Published : 2018.03.15
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Abstract

Purpose: The present study aimed to determine the relationship between serum 25-hydroxyvitamin D (25(OH)D) level and Urinary tract infections (UTIs) in children. Methods: In this case-control study, 70 children with UTI (case group) were compared with 70 healthy children (control group) in terms of serum 25(OH)D levels. The children were between 1 month and 12 years of age. Serum 25(OH)D levels were measured using enzyme-linked immunosorbent assay (ELISA). The results were analyzed and compared between both groups. Results: Among 70 children with UTI (case group), 5 children (7.2%) were male and 65 (92.8%) were female. Among the healthy children (control group), 9 (12.8%) and 61 children (87.2%) were male and female, respectively (P=0.39). The $mean{\pm}standard$ deviation of age in the case and control groups were $53.2{\pm}35.6$ and $36.1{\pm}60.2months$, respectively (P=0.24). The mean level of serum 25(OH)D in the case group was significantly higher than that of the control group ($20.4{\pm}8.6ng/mL$ vs. $16.9{\pm}7.4ng/mL$, P=0.01) Conclusion: This study showed that there was a relationship between serum 25(OH)D levels and UTI in children. It seems that 25(OH)D plays a role in the pathogenesis of UTI.

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References

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