The Korean Journal of Physiology and Pharmacology

The Korean Society of Pharmacology (대한약리학회)
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Ursolic acid in health and disease

  • Seo, Dae Yun (National Research Laboratory for Mitochondrial Signaling, Department of Physiology, BK21 Plus Team, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University) ;
  • Lee, Sung Ryul (National Research Laboratory for Mitochondrial Signaling, Department of Physiology, BK21 Plus Team, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University) ;
  • Heo, Jun-Won (Department of Kinesiology, Inha University) ;
  • No, Mi-Hyun (Department of Kinesiology, Inha University) ;
  • Rhee, Byoung Doo (National Research Laboratory for Mitochondrial Signaling, Department of Physiology, BK21 Plus Team, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University) ;
  • Ko, Kyung Soo (National Research Laboratory for Mitochondrial Signaling, Department of Physiology, BK21 Plus Team, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University) ;
  • Kwak, Hyo-Bum (Department of Kinesiology, Inha University) ;
  • Han, Jin (National Research Laboratory for Mitochondrial Signaling, Department of Physiology, BK21 Plus Team, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University)
  • Received : 2018.02.06
  • Accepted : 2018.03.19
  • Published : 2018.05.01
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Abstract

Ursolic acid (UA) is a natural triterpene compound found in various fruits and vegetables. There is a growing interest in UA because of its beneficial effects, which include anti-inflammatory, anti-oxidant, anti-apoptotic, and anti-carcinogenic effects. It exerts these effects in various tissues and organs: by suppressing nuclear factor-kappa B signaling in cancer cells, improving insulin signaling in adipose tissues, reducing the expression of markers of cardiac damage in the heart, decreasing inflammation and increasing the level of anti-oxidants in the brain, reducing apoptotic signaling and the level of oxidants in the liver, and reducing atrophy and increasing the expression levels of adenosine monophosphate-activated protein kinase and irisin in skeletal muscles. Moreover, UA can be used as an alternative medicine for the treatment and prevention of cancer, obesity/diabetes, cardiovascular disease, brain disease, liver disease, and muscle wasting (sarcopenia). In this review, we have summarized recent data on the beneficial effects and possible uses of UA in health and disease managements.

Keywords

References

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