The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Schisandra Fructus Butanol Fraction Reduces Serum Total Cholesterol and Triglyceride Levels in Hyperlipidemic Mice

오미자 부탄올 분획물이 고지혈증이 유도된 생쥐의 지질대사 및 간조직 유전자 발현에 미치는 영향

  • Kweon, Tae-woo (Dept. of Oriental Internal Medicine, College of Korean Medicine, Dong-Eui University) ;
  • Kim, Young-kyun (Dept. of Oriental Internal Medicine, College of Korean Medicine, Dong-Eui University) ;
  • Kim, Kyoung-min (Dept. of Oriental Internal Medicine, College of Korean Medicine, Dong-Eui University)
  • 권태우 (동의대학교 부속한방병원 한방내과학교실) ;
  • 김영균 (동의대학교 부속한방병원 한방내과학교실) ;
  • 김경민 (동의대학교 부속한방병원 한방내과학교실)
  • Received : 2018.12.08
  • Accepted : 2018.12.29
  • Published : 2018.12.30
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Abstract

The berries of Schisandra chinensis (Schisandra fructus) are given the name Omiza in Korean (五味子), which translates as "five flavor fruit" because they possess all five basic flavors in Korean traditional herbal medicine: salty, sweet, sour, pungent (spicy), and bitter. It is used as a remedy for many ailments: to resist infections, increase skin health, and cure insomnia, coughing, and thirst. This study was designed to investigate the effects of Schisandra fructus butanol fraction (SFB) on serum lipid levels in hyperlipidemic mice. In this experiment, effects on total cholesterol, HDL-cholesterol, and triglyceride in serum were measured. In our results, SFB did not affect weight gain in hyperlipidemic mice. Oral administration of SFB lowered levels of total cholesterol and triglyceride, which were elevated by induction of hyperlipidemia. Finally, administration of SFB regulated changes in gene expression which were related to cell growth and differentiation.

Keywords

References

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