Biomedical Science Letters (대한의생명과학회지)

The Korean Society for Biomedical Laboratory Sciences (대한의생명과학회)
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Chitinase 3-Like 1 (CHI3L1) Polymorphism Contributes to Visceral Obesity and Obesity-related Inflammation Induces Chi3l1 in Adipocytes

  • Kim, A Young (Vital Beautie Research Division, Amorepacific R&D Center) ;
  • Jeong, Hyun Woo (Vital Beautie Research Division, Amorepacific R&D Center) ;
  • Lee, Ji-Hae (Vital Beautie Research Division, Amorepacific R&D Center) ;
  • Choi, Jin Kyu (QA team, Aestura Corporation) ;
  • Kim, Jeong Kee (Department of Genetic Engineering & Graduate School of Biotechnology, College of Life Sciences, Kyung Hee University) ;
  • Hwang, Jae Sung (Department of Genetic Engineering & Graduate School of Biotechnology, College of Life Sciences, Kyung Hee University) ;
  • Seo, Dae-Bang (Vital Beautie Research Division, Amorepacific R&D Center)
  • Received : 2017.11.29
  • Accepted : 2018.03.13
  • Published : 2018.03.31
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Abstract

Abdominal obesity is considered as one of the most risky factors governing the development of metabolic diseases. Here we identify that human chitinase 3-like 1 (CHI3L1, also called YKL-40 in human) single nucleotide polymorphism (SNP), rs883125, is associated with abdominal obesity in Korean women. Korean women subjects with the rs883125 G/G or C/G genotype present higher waist-hip ratio than subjects with C/C genotype suggesting that human subjects who G nucleotide substitution at the rs883125 tended to more accumulate intra-abdominal fat at the abdominal cavity. In addition, Chi3l1 gene expression is increased in adipose tissue from obese mice and pro-inflammatory cytokine enhances Chi3l1 expression in adipocytes, indicating that Chi3l1 is greatly related with obesity and obesity-induced pro-inflammatory responses. Taken together, the minor allele of rs883125 is associated with a higher prevalence of abdominal obesity in Korean women. These findings suggest that genotype of rs883125 can be a biomarker of incident abdominal obesity and abdominal obesity-related metabolic diseases.

Keywords

References

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