Journal of The Korean Society of Clinical Toxicology (대한임상독성학회지)

Korean society of Clincal Toxicology (대한임상독성학회)
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Extracorporeal Membrane Oxygenation and Continuous Renal Replacement Therapy for Treatment of Calcium Channel Blockers, Angiotensin II Receptor Blockers, and Metformin Overdose

에크모와 신대체요법을 이용하여 치료한 칼슘채널차단제, 안지오텐신 수용체 차단제, 메트포민 중독 환자 증례

  • Jeong, Jae Han (Department of Thoracic and Cardiovascular Surgery, Chosun University College of Medicine) ;
  • Sun, Kyung Hoon (Department of Emergency Medicine, Chosun University College of Medicine) ;
  • Park, Yong Jin (Department of Emergency Medicine, Chosun University College of Medicine) ;
  • Kim, Sun Pyo (Department of Emergency Medicine, Chosun University College of Medicine)
  • 정재한 (조선대학교 의과대학 흉부심혈관외과학교실) ;
  • 선경훈 (조선대학교 의과대학 응급의학교실) ;
  • 박용진 (조선대학교 의과대학 응급의학교실) ;
  • 김선표 (조선대학교 의과대학 응급의학교실)
  • Received : 2018.09.17
  • Accepted : 2018.10.22
  • Published : 2018.12.31
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Abstract

An overdose of antihypertensive agents, such calcium channel blockers (CCBs) and angiotensin II receptor blocker (ARBs), and the antihyperglycemic agent, metformin, leads to hypotension and lactic acidosis, respectively. A 40-year-old hypertensive and diabetic man with hyperlipidemia and a weight of 110 kg presented to the emergency room with vomiting, dizziness, and hypotension following an attempted drug overdose suicide with combined CCBs, ARBs, 3-hydroxy-3-methylglutaryl-coemzyme A reductase inhibitors, and metformins. A conventional medical treatment initially administered proved ineffective. The treatment was then changed to simultaneous extracorporeal membrane oxygenation (ECMO) and continuous renal replacement therapy (CRRT), which was effective. This shows that simultaneous ECMO and CRRT can be an effective treatment protocol in cases of ineffective conventional medical therapy for hypotension and lactic acidosis due to an overdose of antihypertensive agents and metformin, respectively.

Keywords

References

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