대한임상독성학회지 (Journal of The Korean Society of Clinical Toxicology)

  • 제16권2호
  • /
  • Pages.141-148
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  • 2018
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  • 1738-1320(pISSN)
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  • 2508-6332(eISSN)
대한임상독성학회 (Korean society of Clincal Toxicology)
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편의점 안전상비의약품 판매 허용 이후 치료 약물 중독

Pharmaceutical Drug Poisoning after Deregulation of Over the Counter Drug Sales: Emergency Department Based In-depth Injury Surveillance

  • 김성호 (인제대학교 일산백병원 응급의학과) ;
  • 김현종 (인제대학교 일산백병원 응급의학과) ;
  • 이지숙 (아주대학교 의과대학 응급의학교실) ;
  • 박준석 (인제대학교 일산백병원 응급의학과) ;
  • 김경환 (인제대학교 일산백병원 응급의학과) ;
  • 신동운 (인제대학교 일산백병원 응급의학과) ;
  • 김훈 (인제대학교 일산백병원 응급의학과) ;
  • 박준민 (인제대학교 일산백병원 응급의학과) ;
  • 전우찬 (인제대학교 일산백병원 응급의학과)
  • Kim, Sung Ho (Department of Emergency Medicine, Inje University, Ilsanpaik Hospital) ;
  • Kim, Hyunjong (Department of Emergency Medicine, Inje University, Ilsanpaik Hospital) ;
  • Lee, Ji Sook (Department of Emergency Medicine, Ajou University, School of Medicine) ;
  • Park, Junseok (Department of Emergency Medicine, Inje University, Ilsanpaik Hospital) ;
  • Kim, Kyung Hwan (Department of Emergency Medicine, Inje University, Ilsanpaik Hospital) ;
  • Shin, Dong Wun (Department of Emergency Medicine, Inje University, Ilsanpaik Hospital) ;
  • Kim, Hoon (Department of Emergency Medicine, Inje University, Ilsanpaik Hospital) ;
  • Park, Joon Min (Department of Emergency Medicine, Inje University, Ilsanpaik Hospital) ;
  • Jeon, Woochan (Department of Emergency Medicine, Inje University, Ilsanpaik Hospital)
  • 투고 : 2018.08.06
  • 심사 : 2018.09.05
  • 발행 : 2018.12.31
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초록

Purpose: The Korean government approved selected nonprescription drugs (Over-The-Counter drug; OTC drug) to be distributed in convenience stores from 15. Nov. 2012. This study examined the changes in the incidence and the clinical outcome of acute pharmaceutical drug poisoning after the deregulation of OTC drug sales. Methods: This study analyzed the data of Emergency Department based Injury In-depth Injury Surveillance (EDIIS), Korea Centers for Disease Control and Prevention, from 2011 to 2014. The following items were examined: age, gender, intention, alcohol association, pharmaceutical drugs resulting acute poisoning, the clinical outcomes in emergency department, and the admission rate of intensive care unit (ICU). This is a retrospective cross section observational study. Results: A total of 10,162 patients were subject to pharmaceutical drug poisoning. Acute poisoning by acetaminophen and other drugs were 1,015 (10.0%) and 9,147 (90.0%) patients, respectively. After the deregulation of OTC drug sales, acute poisoning by other drugs increased from 4,385 to 4,762 patients but acute poisoning by acetaminophen decreased from 538 to 477 patients (p<0.05). The rate of admission of acetaminophen poisoning increased from 36.1% (194/538) to 46.8% (223/477). The admission rate to the ICU by acetaminophen poisoning increased from 4.6% (25/538) to 11.3% (54/477) after the deregulation of OTC drug sales (p<0.05). Conclusion: Since the deregulation of OTC drugs sales, pharmaceutical drug poisoning has increased but acetaminophen poisoning has decreased. The rate of hospitalization and ICU admission by pharmaceutical drug poisoning with or without acetaminophen has also increased.

키워드

참고문헌

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피인용 문헌

  1. 아세트아미노펜 사용 편의성 증가 후 중독발생 위험의 지속적 관리 필요성 vol.18, pp.2, 2018, https://doi.org/10.22537/jksct.2020.18.2.57
  2. 일반의약품과 전문의약품 의도적 음독 자살 시도자 특성 분석 연구 vol.28, pp.2, 2020, https://doi.org/10.22722/kjpm.2020.28.2.116