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Gelatinous Transformation of Bone Marrow Mimicking Malignant Marrow-Replacing Lesion on Magnetic Resonance Imaging in a Patient without Underlying Devastating Disease

  • Lee, Joohee (Department of Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine) ;
  • Yoo, Yeon Hwa (Department of Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine) ;
  • Lee, Sarah (Department of Pathology, Green Cross Laboratories) ;
  • Kim, Hak Sun (Department of Orthopaedic Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine) ;
  • Kim, Sungjun (Department of Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine)
  • Received : 2017.09.21
  • Accepted : 2017.12.01
  • Published : 2018.03.31

Abstract

Gelatinous transformation of bone marrow is characterized by hypoplasia of fat cells with focal loss of hematopoietic cells and deposition of extracellular gelatinous substances. It is known to be associated with devastating underlying diseases that starve bone marrow. Here, we present a case of a patient whose magnetic resonance (MR) imaging findings of vertebral column were interpreted as metastasis or hematologic malignancy, however, the final diagnosis revealed a gelatinous transformation of bone marrow. This is the first report of gelatinous transformation of bone marrow without evidence of underlying devastating disease.

Keywords

References

  1. Bohm J. Gelatinous transformation of the bone marrow: the spectrum of underlying diseases. Am J Surg Pathol 2000;24:56-65 https://doi.org/10.1097/00000478-200001000-00007
  2. Sen R, Singh S, Singh H, Gupta A, Sen J. Clinical profile in gelatinous bone marrow transformation. J Assoc Physicians India 2003;51:585-588
  3. Seaman JP, Kjeldsberg CR, Linker A. Gelatinous transformation of the bone marrow. Hum Pathol 1978;9:685-692
  4. Vande Berg BC, Malghem J, Devuyst O, Maldague BE, Lambert MJ. Anorexia nervosa: correlation between MR appearance of bone marrow and severity of disease. Radiology 1994;193:859-864 https://doi.org/10.1148/radiology.193.3.7972838
  5. Hanrahan CJ, Shah LM. MRI of spinal bone marrow: part 2, T1-weighted imaging-based differential diagnosis. AJR Am J Roentgenol 2011;197:1309-1321 https://doi.org/10.2214/AJR.11.7420
  6. Feng CS. Gelatinous transformation of marrow in a case of acute myelogenous leukemia post-chemotherapy. Am J Hematol 1991;38:220-222 https://doi.org/10.1002/ajh.2830380312
  7. Ifrah N, Saint-Andre JP, de Gentile L, et al. Gelatinous transformation of the bone marrow: manifestation of an acute leukemia? Acta Haematol 1989;82:165-168 https://doi.org/10.1159/000205369
  8. Chong A, Song HC, Oh JR, et al. Gelatinous degeneration of the bone marrow mimicking osseous metastasis on 18F-FDG PET/CT. Clin Nucl Med 2012;37:798-800 https://doi.org/10.1097/RLU.0b013e31825ae455
  9. Brennan CM, Atkins KA, Druzgal CH, Gaskin CM. Magnetic resonance imaging appearance of scurvy with gelatinous bone marrow transformation. Skeletal Radiol 2012;41:357-360 https://doi.org/10.1007/s00256-011-1350-9
  10. Stroup JS, Stephens JR, Baker DL. Gelatinous bone marrow in an HIV-positive patient. Proc (Bayl Univ Med Cent) 2007;20:254-256 https://doi.org/10.1080/08998280.2007.11928299