DOI QR코드

DOI QR Code

히알루론산 마이크로니들 형태에 따른 특성 분석

Analysis of Hyaluronic Acid Microneedle Characteristics as Its Shapes

  • 류종훈 (건양대학교 의공학부) ;
  • 신현영 (대구경북과학기술원 뉴바이올로지학과) ;
  • 이정건 (에스스킨) ;
  • 태기식 (건양대학교 의공학부) ;
  • 김민석 (대구경북과학기술원 뉴바이올로지학과)
  • Ryu, Jong Hoon (Dept. of Biomedical Engineering, Konyang University) ;
  • Shin, Hyun Young (Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology (DGIST)) ;
  • Lee, Jeong-Gun (S-Skin Co., Ltd.) ;
  • Tae, Ki-Sik (Dept. of Biomedical Engineering, Konyang University) ;
  • Kim, Minseok S. (Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology (DGIST))
  • 투고 : 2017.11.16
  • 심사 : 2017.12.18
  • 발행 : 2018.02.28

초록

Conventional drug delivery methods mainly include subcutaneous injection and oral administration. Subcutaneous injection has the advantages of delivering the correct concentration, but it might cause pain and trauma to patients. Although oral administrations do not accompany pain as the subcutaneous injection, unexpected side effects may occur because they undergo digestion process and it is not easy for many drugs to be exposed to targeted sites with proper concentration. While dissolving microneedles have been extensively studied to overcome the limitations of conventional subcutaneous injection, the effects on microneedle shapes for drug release have not been fully explored. In this study, the characteristics of hyaluronic acid microneedles for cone and quadrangular pyramidal shapes were examined by the size, volume, contact surface area, skin permeability, and dissolution rate. As a result, the cone shapes of hyaluronic acid microneedles had high skin permeability, and the quadrangular pyramid of shapes hyaluronic acid microneedles showed a fast dissolution rate, given by the large contact area on the skin. Based on the results, we could confirm that the shape of a dissolving microneedles can affect skin permeability and the drug delivery rate.

키워드

참고문헌

  1. Y.C. Kim and J. H. Park, M. R. Prausnitz "Microneedles for drug and vaccine delivery," Advanced Drug Delivery Reviews, vol. 64, no. 14, pp. 1547-1568, 2012. https://doi.org/10.1016/j.addr.2012.04.005
  2. Hamilton J.G., "Needle phobia: a neglected diagnosis," J Fam Pract., vol. 41, no. 2, pp. 169-175, 1995.
  3. Kermode M, "Unsafe injections in low-income country health settings: need for injection safety promotion to prevent the spread of blood-borne viruses," Health Promot Int., vol. 19, no. 1, pp. 95-103, 2004. https://doi.org/10.1093/heapro/dah110
  4. Y.H. Park, S.K. Ha, I. Choi, K.S. Kim, J. Park, N. Choi, B. Kim and J. H. Sung, "Fabrication of degradable carboxymethyl cellulose (CMC) microneedle with laser writing and replica molding process for enhancement of transdermal drug delivery," Biotechnology and Bioprocess Engineering, vol. 21, no. 1, pp. 110-118, 2010. https://doi.org/10.1007/s12257-015-0634-7
  5. J.H. Park, S.O. Choi, S. Seo, Y.B. Choy and M. R. Prausnitz, "A microneedle roller for transdermal drug delivery," Eur J Pharm Biopharm, vol. 76, no. 2, pp. 282-289, 2010. https://doi.org/10.1016/j.ejpb.2010.07.001
  6. G. Ma and C. Wu, "Microneedle, bio-microneedle and bioinspired microneedle: A review," Journal of Controlled Release, vol. 251, no. 10, pp. 11-23, 2017. https://doi.org/10.1016/j.jconrel.2017.02.011
  7. M.R. Prausnitz, "Microneedles for transdermal drug delivery," Advanced Drug Delivery Reviews, vol. 56, no. 5, pp. 581-587, 2004. https://doi.org/10.1016/j.addr.2003.10.023
  8. M.C. Chen, Ling M.H and Lai K.Y, Pramudityo E., "Chitosan microneedle patches for sustained transdermal delivery of macromolecules," Biomacromolecules, vol. 13, no. 12, pp. 4022-4031, 2012. https://doi.org/10.1021/bm301293d
  9. S.G. Lee, J.H. Jeong, K.M. Lee, K.H. Jeong, H. Yang, M. Kim, H. Jung, S. Lee and Y. W. Choi, "Nanostructured lipid carrier-loaded hyaluronic acid microneedles for controlled dermal delivery of a lipophilic molecule," Int J Nanomedicine., vol. 9, pp. 289-299, 2014.
  10. S.P. Sullivan, D.G. Koutsonanos, M.P. Martin, J.W. Lee, V. Zarnitsyn, S. O. Choi, N. Murthy and R.W. Compans, I. Skountzou and M.R. Prausnitz, "Dissolving polymer microneedle patches for influenza vaccination," Nature Medicine, vol. 16, pp. 915-920, 2010. https://doi.org/10.1038/nm.2182
  11. L.Y. Chu and M.R. Prausnitz "separable arrowhead microneedles," J Control Release, vol. 149, no. 3, pp. 242-249, 2011. https://doi.org/10.1016/j.jconrel.2010.10.033
  12. J.H. Park, M.G. Allen and M.R. Prausnitz, "Biodegradable polymer microneedles: Fabrication, mechanics and transdermal drug delivery," Journal of Controlled Release, vol. 104, no. 1, pp. 51-66, 2005. https://doi.org/10.1016/j.jconrel.2005.02.002
  13. J.W. Lee, J. H. Park and M.R. Prausnitz, "Dissolving microneedles for transdermal drug delivery," Biomaterials, vol. 29, no. 13, pp. 2113-2124, 2008. https://doi.org/10.1016/j.biomaterials.2007.12.048
  14. H.S. Gill, D. D. Denson, B. A. Burris and M.R. Prausnitz, "Effect of microneedle design on pain in human subjects," Clin J Pain, vol. 24, no. 7, pp. 585-594, 2008. https://doi.org/10.1097/AJP.0b013e31816778f9
  15. M.Kim, T.Kim, D.S. Kim and W.K. Chung, "Curved Microneedle Array-Based sEMG Electrode for Robust Long-Term Measurements and High Selectivity," Sensors, vol. 15, pp. 16265-16280, 2015.