Journal of Korean Dental Science

  • 제11권2호
  • /
  • Pages.82-85
  • /
  • 2018
  • /
  • 2005-4742(pISSN)
  • /
  • 2713-7651(eISSN)
대한치의학회 (Korean Academy of Dental Science)
권호 표지
DOI QR코드

DOI QR Code

Diagnosis of Acute Leukemia from Oral Manifestation

  • Kang, Min-Hye (Department of Oral and Maxillofacial Surgery, Gachon University Gil Medical Center) ;
  • On, Dohyun (Department of Oral and Maxillofacial Surgery, Gachon University Gil Medical Center) ;
  • Kim, Jin Woo (Department of Oral and Maxillofacial Surgery, Gachon University Gil Medical Center) ;
  • Ryu, Jaeyoung (Department of Oral and Maxillofacial Surgery, Gachon University Gil Medical Center)
  • 투고 : 2018.07.28
  • 심사 : 2018.12.20
  • 발행 : 2018.12.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Leukemia is a hematological malignant disease with various clinical symptoms. Due to the fatal nature of the disease, early detection is important. Oral manifestations include ulcers and gingival enlargement with bleeding. Moreover, myeloid sarcoma or opportunistic infections may also occur. This report introduces a 31-year-old male presenting with generalized gingival enlargement with bleeding and another 81-year-old female with neoplasm on the left retromolar area. Both were diagnosed as acute monocytic leukemia. These cases implicate that gingival enlargement or mucosal lesion in the oral cavity may represent underlying systemic diseases. Related to this, it has to be reminded that making timely diagnosis and referral according to the clinical findings is crucial.

키워드

COHHB6_2018_v11n2_82_f0001.png 이미지

Fig. 1. Clinical photographs (A, frontal; B, upper occlusal; C, lower occlusal) of frst patient showing generalized gingival enlargement.

COHHB6_2018_v11n2_82_f0002.png 이미지

Fig. 2. Clinical photographs of second patient showing ulcerated proliferative lesion on left retromolar area.

참고문헌

  1. Schlosser BJ, Pirigyi M, Mirowski GW. Oral manifestations of hematologic and nutritional diseases. Otolaryngol Clin North Am. 2011; 44: 183-203, vii. https://doi.org/10.1016/j.otc.2010.09.007
  2. Guan G, Firth N. Oral manifestations as an early clinical sign of acute myeloid leukaemia: a case report. Aust Dent J. 2015; 60: 123-7. https://doi.org/10.1111/adj.12272
  3. McCord C, Johnson L. Oral manifestations of hematologic disease. Atlas Oral Maxillofac Surg Clin North Am. 2017; 25: 149-62. https://doi.org/10.1016/j.cxom.2017.04.007
  4. Edens MH, Khaled Y, Napenas JJ. Introduction to oral manifestations of systemic diseases: evaluation of the patient. Atlas Oral Maxillofac Surg Clin North Am. 2017; 25: 85-92. https://doi.org/10.1016/j.cxom.2017.04.001
  5. Gallipoli P, Leach M. Gingival infiltration in acute monoblastic leukaemia. Br Dent J. 2007; 203: 507-9. https://doi.org/10.1038/bdj.2007.994
  6. Hasan S, Khan NI, Reddy LB. Leukemic gingival enlargement: report of a rare case with review of literature. Int J Appl Basic Med Res. 2015; 5: 65-7. https://doi.org/10.4103/2229-516X.149251
  7. McKenna SJ. Leukemia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000; 89: 137-9. https://doi.org/10.1067/moe.2000.102386
  8. Dreizen S, McCredie KB, Keating MJ, Luna MA. Malignant gingival and skin "infiltrates" in adult leukemia. Oral Surg Oral Med Oral Pathol. 1983; 55: 572-9. https://doi.org/10.1016/0030-4220(83)90373-0
  9. Barrett AP. Oral changes as initial diagnostic indicators in acute leukemia. J Oral Med. 1986; 41: 234-8.
  10. Weckx LL, Hidal LB, Marcucci G. Oral manifestations of leukemia. Ear Nose Throat J. 1990; 69: 341-2, 345-6.
  11. Demirer S, Ozdemir H, Sencan M, Marakoglu I. Gingival hyperplasia as an early diagnostic oral manifestation in acute monocytic leukemia: a case report. Eur J Dent. 2007; 1: 111-4.