대한방사성의약품학회지 (Journal of Radiopharmaceuticals and Molecular Probes)

  • 제4권2호
  • /
  • Pages.115-120
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  • 2018
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  • 2384-1583(pISSN)
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  • 2508-3848(eISSN)
대한방사성의약품학회 (Korean Society of Radiopharmaceuticals and Molecular Probes)
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Radiolabeled 2D graphitic nanomaterials and their possibility for molecular imaging applications

  • Kang, Seok Min (Department of Chemistry and Chemical Engineering, Inha University) ;
  • Kim, Chul Hee (Department of Chemistry and Chemical Engineering, Inha University) ;
  • Kim, Dong Wook (Department of Chemistry and Chemical Engineering, Inha University)
  • 투고 : 2018.12.16
  • 심사 : 2018.12.22
  • 발행 : 2018.12.30
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초록

In recent years, many researchers have attempted to make use of 2D nanoparticles as molecular imaging probes since extensive investigations proved that 2D nanoparticles in the body tends to accumulate certain lesions by enhanced permeability and retention (EPR) effect. For example, graphene and carbon nitride which have high surface area and modifiable properties showed good biocompatibility and targetability when it used as imaging probes. However, poor dispersibility in physiological mediums and its uncontrolled size limited its usage in bio-application. Therefore, oxidation process and mechanical exfoliation have been developed for overcoming these problems. In this paper, we highlight the several major methods to synthesize biocompatible 2D nanomaterials like graphene and carbon nitride especially for molecular imaging study including positron emission tomography (PET).

키워드

DHBSB1_2018_v4n2_115_f0001.png 이미지

Figure 1. Proposed structures of various 2D materials. (A) Graphene, (B) Graphene oxide, (C) Carbon nitride (g-C3N4), (D) Oxidized carbon nitride (OCN).

DHBSB1_2018_v4n2_115_f0002.png 이미지

Figure 2. Illustration of 18F-labelled graphene oxide by nucleophilic fluorination.

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Figure 3. Illustration of 64Cu-chelated nanographene conjugates.

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Figure 4. Illustration of DTPA-graphene oxide complex by ϖ – ϖ stacking.

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Figure 5. (A) Illustration of synthesis of PEG-OCN. (B) TEM image of water-dispersed PEG-OCN nono-material. (C) Confocal fluorescence microscopic image of RAW264.7 cells using PEG-OCN nanodots after incubation with different concentrations (50 and 100 μg/mL).

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