Journal of Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Chemical constituents of Dicentra spectabilis and their anti-inflammation effect

  • Kim, A Hyeon (Division of Traditional Korean Medicine Resource, National Development Institute of Korea Medicine) ;
  • Jang, Ji Hun (Division of Traditional Korean Medicine Resource, National Development Institute of Korea Medicine) ;
  • Woo, Kyeong Wan (Division of Traditional Korean Medicine Resource, National Development Institute of Korea Medicine) ;
  • Park, Jong Eel (Division of Traditional Korean Medicine Resource, National Development Institute of Korea Medicine) ;
  • Lee, Ki Ho (Division of Traditional Korean Medicine Resource, National Development Institute of Korea Medicine) ;
  • Jung, Ho Kyung (Division of Traditional Korean Medicine Resource, National Development Institute of Korea Medicine) ;
  • An, Byeongkwan (Division of Traditional Korean Medicine Resource, National Development Institute of Korea Medicine) ;
  • Jung, Won Seok (Division of Traditional Korean Medicine Resource, National Development Institute of Korea Medicine) ;
  • Ham, Seong Ho (Division of Traditional Korean Medicine Resource, National Development Institute of Korea Medicine) ;
  • Cho, Hyun Woo (Division of Traditional Korean Medicine Resource, National Development Institute of Korea Medicine)
  • Received : 2017.10.30
  • Accepted : 2018.01.09
  • Published : 2018.03.31
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Abstract

Column chromatographic separation of the MeOH extract from the roots of Dicentra spectabilis yielded fourteen compounds, menisdaurin (1), menisdaurilide (2), trans-N-p-coumaroyltyramine (3), trans-N-p-feruloyltyramine (4), 4-O-feruloylquinicacid (5), chlorogenic acid (6), 3-O-feruloylquinicacid (7), ferulic acid (8), protopine (9), Kaempferol 3,7-di-O-${\beta}-{\text\tiny{D}}$-glucopyranoside (10), kaempferol 3-O-${\beta}-{\text\tiny{D}}$-glucopyranosyl-7-O-${\alpha}-{\text\tiny{L}}$-rhamnopyranoside (11), ${\alpha}-rhamnoisorobin$ (12), astragalin (13), and nicotiflorin (14). Their structures were determined on the basis of NMR spectroscopic data. Among them, compound 1, 3-8, and 10-14 isolated from this plant were reported for the first time. The isolated compounds (1-14) were tested for nitric oxide (NO) inhibitory activity on lipopolysaccharide-stimulated RAW 264.7 cells. Compound 3, 4 and 12 significantly inhibited NO production. Moreover, Compound 3 suppressed pro-inflammatory cytokines ($TNF-{\alpha}$, $IL-1{\beta}$ and IL-6) in a dose- dependent manner. These data suggest that compound 3 possess anti-inflammatory activity and might be useful natural materials for development of anti-inflammatory agent.

Keywords

References

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