DOI QR코드

DOI QR Code

Effects of Therapeutic Exercise on Fatigue and Anxiety of Cachexia Patients(Case Report)

악액질(cachexia) 환자에게 적용한 운동치료가 피로와 불안에 미치는 영향(단일사례 보고)

  • An, Hyunkyu (Dept. of Physical Therapy, Graduate School of Namsaoul University) ;
  • Yoon, Junggyu (Dept. of Physical Therapy, Namsaoul University)
  • 안현규 (남서울대학교 대학원) ;
  • 윤정규 (남서울대학교 물리치료학과)
  • Received : 2018.08.22
  • Accepted : 2018.10.05
  • Published : 2018.12.30

Abstract

Purpose : Cachexia, is a complex metabolic syndrome associated with underlying illness and characterized by loss of muscle with or without loss of fat mass. Patients with cachxia shows various symptoms including fatigue, anxiety, pain, sleep disorders, and poor appetite. Medications therapy, dietary and exercise therapy, and emotional support are recommended to treat patients with cachexia. However, evidence-based research verifying the role of exercise therapy in patients with cachexia is limited. The purpose of this study was to investigate the effects of therapeutic exercise on fatigue and anxiety in patients with cachexia. Methods : Case report. A 29-year-old woman was diagnosed with cachexia. Following 2 weeks of inpatient and 4 weeks of out-patient treatment. we assessed her weight, as well as pain, fatigue, and anxiety level. As an the patient exercised for an hour 5 times a week for 2 weeks,-and during the outpatient visit, she exercised for an hour twice a week for 4 weeks. Her weight was measured using a weighting scale. Pain was assessed using the visual analog scale, and fatigue and anxiety levels were assessed using questionnaires. Results : Following 6 weeks of treatment, exercise therapy a positively affected the patient's weight, as well as pain, fatigue, and anxiety levels. We observed a weight gain of 4.5 kg, pain reduction of 5.1 points. Fatigue reduction of 43 points, anxiety reduction of total 41 points. Conclusion : Exercise therapy positively affects weight, as well as pain, fatigue, and anxiety levels in patients with cachexia. However, generalization of this observation is inappropriate based on this single case study.

Keywords

References

  1. Aoyagi T, Terracina KP, Raza A, et al(2015). Cancer cachexia, mechanism and treatment. World J Gastrointest Oncol, 7(4), 17-29. https://doi.org/10.4251/wjgo.v7.i4.17
  2. Back SG, Min YS(2015). Effects of using convergence digital contents for high-intensity interval exercise on growth hormone and fatigue elements in middle aged women. Journal of Digital Convergence, 13(9), 523-530. https://doi.org/10.14400/JDC.2015.13.9.523
  3. Chang HK(2006). A study on chronic pain, pain beliefs, pain coping, and fatigue in the elderly. Korean J Adult Nurs, 18(3), 377-385.
  4. Cho EH, Jun TW, Kim JH(2010). Exercise and cancer. Sports Sci Rev, 4(2), 1-12.
  5. Choi SG(2011). Recent advances in cancer cachexia, J Korean Oncol Nurs, 11(1), 20-25. https://doi.org/10.5388/jkon.2011.11.1.20
  6. Choi PB(2013). Influence of a regular aerobic exercise on body composition and immune cell in breast cancer patients undergoing surgery. Korea J Sports Sci, 22(4), 961-970.
  7. Evans WJ, Morley JE, Argiles J, et al(2008). Cachexia: A new definition. Clin Nutr, 27, 793-799. https://doi.org/10.1016/j.clnu.2008.06.013
  8. Falla D, Rainoldi A, Merletti R, et al(2003). Myoelectric manifestations of sternocleidomastoid and anterior scalene muscle fatigue in chronic neck pain patients. Clin Neurophysiol, 114(3), 488-495. https://doi.org/10.1016/S1388-2457(02)00418-2
  9. Fearon KCH, Meyenfeldt MF, Moses AGW, et al(2003). Effect of a protein and energy dense n-3 fatty acid enriched oral supplement on loss of weight and lean tissue in cancer cachexia: a randomised double blind trial. Gut, 52(10), 1479-1486. https://doi.org/10.1136/gut.52.10.1479
  10. Han JH, Lee JE, Park JH, et al(2014). Effect of a 12 week-aerobic exercise program on physical fitness, depress, and cognitive function in the elderly. Exerc Sci, 23(4), 375-385. https://doi.org/10.15857/ksep.2014.23.4.375
  11. Han SH(2000). Effect of exercise program with strategies promoting self-efficacy on health status and exercise capacity in patients after the stem cell transplantation. Graduate school of Yonsei University, Republic of Korea, Unpublished Doctoral dissertation.
  12. Han SH(2004). Exercise for patients with cancer. Korean J Health Promot Dis Prev, 4(1), 1-9.
  13. Jeong YH, Kim JI(2010). Effects of 9-week self-help management.aquatic exercise program on pain, flexibility, balance, fatigue, and self-efficacy in the patients with osteoarthritis. Journal of Muscle and Joint Health, 17(1), 47-57. https://doi.org/10.5953/JMJH.2010.17.1.047
  14. Jo KS, Ji MY, Oh JK(2017). The effects of 8 weeks combined exercise program on body composition, physical fitness, complete blood count, cancer related fatigue, and balance ability in blood cancer patients. Korea Society for Wellness, 12(4), 589-600. https://doi.org/10.21097/ksw.2017.11.12.4.589
  15. Kang JI, Jeong DK(2016). The effect of abdominal drawing-in maneuver for the wellness of patients with chronic neck pain : focused on neck muscle fatigue and neck disability index. Journal of The Korea Entertainment Industry Association, 10(6), 389-396. https://doi.org/10.21184/jkeia.2016.12.10.6.389
  16. Kim CS, Kim SU, Park KS(2002). Relations between anxiety and pain coping responses in chronic pain patients. Korean J Clin Psychol, 21(1), 45-55.
  17. Kim MS, Ryu KH, Lee EN(2012). The effect of a 12-week combined-exercise program on physical fitness and fatigue for cancer survivors. Journal Muscle Joint Health, 19(1), 5-15. https://doi.org/10.5953/JMJH.2012.19.1.005
  18. Kisner C, Colby LA(2010). Therapeutic exercise. 5th ed, Seoul, Yeongmun Publishing Company, pp.1-38.
  19. Lee BK, LEE JS, Kim TS(2013). The influence of 4 wks complex therapeutic exercise on visual analog of pain and range of motion for middle-aged women with breast cancer-related lymphedema. J Korea Soc Phys Med, 8(2), 153-161. https://doi.org/10.13066/kspm.2013.8.2.153
  20. Lee HR(2013). Management of non-pain symptoms in terminally ill cancer patients : based on national comprehensive cancer network guidelines. Korean J Hosp Palliat Care, 16(4), 205-215. https://doi.org/10.14475/kjhpc.2013.16.4.205
  21. Lee NR, Yun SJ, Choi KS(2016). The effect of pilates exercise on isokinetic muscular strength and balance in lower limb's for aged women. Journal of The Korea Academia-Industrial, 19(11), 691-700.
  22. Lenk K, Schuler G, Adams V(2010). Skeletal muscle wasting cachexia and sarcopenia: molecular pathophysiology and impact of exercise training. J Cachexia Sarcopenia Muscle, 1(1), 9-21. https://doi.org/10.1007/s13539-010-0007-1
  23. Lim IS(2011). effects of aerobic training during 12 week on the changes of blood lactate, CK, LDH and neurotransmetter concentration following maximal exercise. Korean J Phys Educ, 50(6), 439-445.
  24. Pedersen BK, Saltin B(2006). Evidence for prescribing exercise as therapy in chronic disease. Scand J Med Sci Sports, Suppl 1, 3-63.
  25. Piper BF, Dibble SL, Dodd MJ, et al(1998). The revised piper fatigue scale: psycometric evaluation in women with breast cancer. Oncol Nurs Forum, 25(4), 677-684.
  26. Scott J, Huskisson EC(1976). Graphic representation of pain. Pain, 2(2), 175-184. https://doi.org/10.1016/0304-3959(76)90113-5
  27. Shin HC, Park YW, Kim CH, et al(2006). Fatigue related in chronic fatigue patients with chronic widespread pain after treatment. Korean J Family Med, 27(6), 442-448.
  28. Sohn SK(2002). Releationship between fatigue and sleep quality in patients with cancer. Korean Acad Soc Adult Nurs, 14(3), 378-389.
  29. Spielberger CD(1975). Anxiety : state-trait process. 1th ed, New York, John Wiley & Sons Inc., pp.115-143.
  30. Spielberger CD, Gorsuch RL, Lushene R, et al(2010). State-trait anxiety inventory for adults. USA, Mind Garden, Inc. pp.1-75.
  31. Tisdale MJ(2009). Mechanisms of cancer cachexia. Physiol Rev, 89, 381-410. https://doi.org/10.1152/physrev.00016.2008
  32. Yook YS(2012). The influence of combined healing exercise program on anxiety, depression and quality of life of depressed patients. Korean J Sport Psychol, 23(4), 253-273.
  33. Zhou T, Yang K, Thapa S, et al.(2017). Differences in symptom burden among cancer patients with different stages of cachexia. J Pain Symptom Manage, 53(5), 919-926. https://doi.org/10.1016/j.jpainsymman.2016.12.325