Korean Journal of Cognitive Science (인지과학)

The Korean Society for Cognitive Science (한국인지과학회)
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Interactivity within large-scale brain network recruited for retrieval of temporally organized events

시간적 일화기억인출에 관여하는 뇌기능연결성 연구

  • Nah, Yoonjin (Department of Psychology, Yonsei University) ;
  • Lee, Jonghyun (Graduate Program in Cognitive Science, Yonsei University) ;
  • Han, Sanghoon (Department of Psychology, Yonsei University)
  • 나윤진 (연세대학교 심리학과) ;
  • 이종현 (연세대학교 인지과학 협동과정) ;
  • 한상훈 (연세대학교 심리학과)
  • Received : 2018.07.23
  • Accepted : 2018.08.08
  • Published : 2018.09.30
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Abstract

Retrieving temporal information of encoded events is one of the core control processes in episodic memory. Despite much prior neuroimaging research on episodic retrieval, little is known about how large-scale connectivity patterns are involved in the retrieval of sequentially organized episodes. Task-related functional connectivity multivariate pattern analysis was used to distinguish the different sequential retrieval. In this study, participants performed temporal episodic memory tasks in which they were required to retrieve the encoded items in either the forward or backward direction. While separately parsed local networks did not yield substantial efficiency in classification performance, the large-scale patterns of interactivity across the cortical and sub-cortical brain regions implicated in both the cognitive control of memory and goal-directed cognitive processes encompassing lateral and medial prefrontal regions, inferior parietal lobules, middle temporal gyrus, and caudate yielded high discriminative power in classification of temporal retrieval processes. These findings demonstrate that mnemonic control processes across cortical and subcortical regions are recruited to re-experience temporally-linked series of memoranda in episodic memory and are mirrored in the qualitatively distinct global network patterns of functional connectivity.

부호화된 사건의 시간적 정보를 기반으로 한 인출은 일화기억의 중요한 통제기제 중 하나이다. 기억인출과 관련한 수많은 신경영상 연구들이 진행되었음에도 아직 시간적으로 구성된 일화기억의 인출에 관여하는 뇌신경연결망 패턴에 대해서는 알려진 바가 많지 않다. 본 연구에서는 두가지 다른 순차적 인출 뇌신경 기제를 구분하기 위하여 과제기반 기능적 연결성 다변량 패턴분석 방법을 사용하였다. 참가자들은 시간적 일화기억과제를 수행하였고, 순서대로 부호화된 기억자극을 순방향 혹은 역방향으로 인출하도록 지시를 받았다. 부분적으로 분류된 국소적 신경네트워크 패턴은 두 인출기제를 잘 구분하지 못한 반면, 기억과 관련된 인지통제 영역과 목표-지향적 인지기제처리에 관련된 것으로 알려진 여러 피질-피질하 노드들을 아우르는 전뇌신경네트워크 패턴은 시간적 일화기억 인출기제를 잘 구분하였다. 이 영역들은 측면/내측 전전두엽 영역, 하부 두정엽, 중간 측두회, 선조체 영역 등을 포함하며 기계학습을 이용한 분류에서 높은 분류 예측률을 보였다. 본 연구의 결과는 일화기억의 시간적 인출기제에 관여하는 피질-피질하 여러 영역의 관여를 확인하였고, 대역적 네트워크 패턴의 기능적 연결성이 질적으로 다른 인출기제에 관여함을 확인하였다는데에 중요성을 갖는다.

Keywords

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