참고문헌
- Esteller A. Physiology of bile secretion. World J Gastroenterol 2008;14(37):5641-9. https://doi.org/10.3748/wjg.14.5641
- Houten SM, Watanabe M, Auwerx J. Endocrine functions of bile acids. Embo J 2006;25(7):1419-25. https://doi.org/10.1038/sj.emboj.7601049
- Zhu C, Fuchs C, Halilbasic E, et al. Bile acids in regulation of inflammation and immunity: friend or foe? Clin Exp Rheumatol 2016;34(4 Suppl 98):25-31.
- Lefebvre P, Cariou B, Lien F, et al. Role of bile acids and bile acid receptors in metabolic regulation. Physiol Rev 2009;89(1):147-91. https://doi.org/10.1152/physrev.00010.2008
- Handelsman Y. Role of bile acid sequestrants in the treatment of type 2 diabetes. Diabetes Care 2011;34(Suppl 2):S244-50. https://doi.org/10.2337/dc11-s237
- Neuschwander-Tetri BA, Loomba R, Sanyal AJ, et al. Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial. Lancet 2015;385(9972):956-65. https://doi.org/10.1016/S0140-6736(14)61933-4
- U.S. National Library of Medicine. Study of the effects of obeticholic acid on farnesoid X receptor expression in jejunum and on gut microbiota in morbidly obese patients and healthy volunteers. Available from https://clinicaltrialsgov/ct2/show/NCT02532335?cond=obeticholic+acid&rank=5. Accessed Aug 29, 2018.
- Aguiar Vallim TQ, Tarling EJ, et al. Pleiotropic roles of bile acids in metabolism. Cell Metab 2013;17(5):657-69. https://doi.org/10.1016/j.cmet.2013.03.013
- Han CY. Update on FXR biology: promising therapeutic target? Int J Mol Sci 2018;19(7):pii:2069.
- Chiang JY. Bile acids: regulation of synthesis. J Lipid Res 2009;50(10):1955-66. https://doi.org/10.1194/jlr.R900010-JLR200
- Lazaridis KN, Gores GJ, Lindor KD. Ursodeoxycholic acid 'mechanisms of action and clinical use in hepatobiliary disorders'. J Hepatol 2001;35(1):134-46. https://doi.org/10.1016/S0168-8278(01)00092-7
- Monte MJ, Marin JJ, Antelo A, et al. Bile acids: chemistry, physiology, and pathophysiology. World J Gastroenterol 2009;15(7): 804-16. https://doi.org/10.3748/wjg.15.804
- Afroze S, Meng F, Jensen K, et al. The physiological roles of secretin and its receptor. Ann Transl Med 2013;1(3):29.
- Li T, Chiang JY. Bile acid signaling in metabolic disease and drug therapy. Pharmacol Rev 2014;66(4):948-83. https://doi.org/10.1124/pr.113.008201
- Thomas C, Pellicciari R, Pruzanski M, et al. Targeting bile-acid signalling for metabolic diseases. Nat Rev Drug Discov 2008;7(8):678-93. https://doi.org/10.1038/nrd2619
- Makishima M, Lu TT, Xie W, et al. Vitamin D receptor as an intestinal bile acid sensor. Science 2002;296(5571):1313-6. https://doi.org/10.1126/science.1070477
- Matsubara T, Li F, Gonzalez FJ. FXR signaling in the enterohepatic system. Mol Cell Endocrinol 2013;368(1-2):17-29. https://doi.org/10.1016/j.mce.2012.05.004
- Claudel T, Staels B, Kuipers F. The farnesoid X receptor: a molecular link between bile acid and lipid and glucose metabolism. Arterioscler Thromb Vasc Biol 2005;25(10):2020-30. https://doi.org/10.1161/01.ATV.0000178994.21828.a7
- Zhang Y, Kast-Woelbern HR, Edwards PA. Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation. J Biol Chem 2003;278(1):104-10. https://doi.org/10.1074/jbc.M209505200
- Thomas C, Gioiello A, Noriega L, et al. TGR5-mediated mile acid sensing controls glucose homeostasis. Cell Metab 2009;10(3):167-77. https://doi.org/10.1016/j.cmet.2009.08.001
- Kawamata Y, Fujii R, Hosoya M, et al. A G protein-coupled receptor responsive to bile acids. J Biol Chem 2003;278(11):9435-40. https://doi.org/10.1074/jbc.M209706200
- Massotte, Dominique, et al. Structure-function relationships in G protein-coupled receptors. In; Devi, Lakshmi A, eds. The G protein-coupled receptors handbook, 16, New York: Humana Press, 2005:3-4
- Forman BM, Goode E, Chen J, et al. Identification of a nuclear receptor that is activated by farnesol metabolites. Cell 1995;81(5):687-93. https://doi.org/10.1016/0092-8674(95)90530-8
-
Chiang JY, Kimmel R, Weinberger C, et al. Farnesoid X receptor responds to bile acids and represses cholesterol
$7{\alpha}$ -hydroxylase gene (CYP7A1) transcription. J Biol Chem 2000;275(15):10918-24. https://doi.org/10.1074/jbc.275.15.10918 - Kim I, Ahn S-H, Inagaki T, et al. Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine. J Lipid Res 2007;48(12):2664-72. https://doi.org/10.1194/jlr.M700330-JLR200
- Pineda Torra I, Claudel T, Duval C, et al. Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor. Mol Endocrinol 2003;17(2):259-72. https://doi.org/10.1210/me.2002-0120
- Cyphert HA, Ge X, Kohan AB, et al. Activation of the farnesoid X receptor induces hepatic expression and secretion of fibroblast growth factor 21. J Biol Chem 2012;287(30):25123-38. https://doi.org/10.1074/jbc.M112.375907
- Kharitonenkov A, Shiyanova TL, Koester A, et al. FGF-21 as a novel metabolic regulator. J Clin Invest 2005;115(6):1627-35. https://doi.org/10.1172/JCI23606
- Claudel T, Zollner G, Wagner M, et al. Role of nuclear receptors for bile acid metabolism, bile secretion, cholestasis, and gallstone disease. Biochim Biophys Acta 2011;1812(8):867-78. https://doi.org/10.1016/j.bbadis.2010.12.021
- Nevens F, Andreone P, Mazzella G, et al. A placebo-controlled trial of obeticholic acid in primary biliary cholangitis. N Engl J Med 2016; 375(7):631-43. https://doi.org/10.1056/NEJMoa1509840
- Lackey DE, Olefsky JM. Regulation of metabolism by the innate immune system. Nat Rev Endocrinol 2016;12(1):15-28. https://doi.org/10.1038/nrendo.2015.189
- Chavez-Talavera O, Tailleux A, Lefebvre P, et al. Bile acid control of metabolism and inflammation in obesity, type 2 diabetes, dyslipidemia, and nonalcoholic fatty liver disease. Am J Gastroenterol 2017; 152(7):1679-94.e3.
- World health organization international obesity task force, The asianpacific perspective: redefining obesity and its treatment. Geneva: WHO Western Pacific Region, 2000;17-18.
- Park JH. Measuring BMI cutoff points of korean adults using morbidity of BMI-related diseases. Korean J Obesity. 2011;20(1):36-43. https://doi.org/10.7570/kjo.2011.20.1.36
- Hamilton MT, Hamilton DG, Zderic TW. The role of low energy expenditure and sitting on obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease. Diabetes 2007;56(11):2655-67. https://doi.org/10.2337/db07-0882
- Watanabe M, Houten SM, Mataki C, et al. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature 2006;439(7075):484-9. https://doi.org/10.1038/nature04330
- Drucker DJ, Nauck MA. The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 2006;368(9548):1696-705. https://doi.org/10.1016/S0140-6736(06)69705-5
- Astrup A, Rossner S, Van Gaal L, et al. Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study. Lancet 2009;374(9701):1606-16. https://doi.org/10.1016/S0140-6736(09)61375-1
- Molinaro A, Wahlstrom A, Marschall HU. Role of bile acids in metabolic control. Trends Endocrinol Metab 2018;29(1):31-41. https://doi.org/10.1016/j.tem.2017.11.002
- Kars M, Yang L, Gregor MF, et al. Tauroursodeoxycholic acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women. Diabetes 2010;59(8):1899-905. https://doi.org/10.2337/db10-0308
피인용 문헌
- Bile Acid Receptors in Cholangiocyte vol.26, pp.4, 2018, https://doi.org/10.15279/kpba.2021.26.4.254