Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
권호 표지
DOI QR코드

DOI QR Code

Associations of Puerperal Metritis with Serum Metabolites, Uterine Health, Milk Yield, and Reproductive Performance in Dairy Cows

  • Jeong, Jae-Kwan (Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University) ;
  • Kang, Hyun-Gu (Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University) ;
  • Kim, Ill-Hwa (Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University)
  • Received : 2018.10.22
  • Accepted : 2018.11.16
  • Published : 2018.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

We aimed to identify the relationships between puerperal metritis (PM) and serum metabolites, uterine health, milk yield, and reproductive performance in dairy cows. Blood samples from 150 Holstein dairy cows were collected just after calving, and at 1, 2, and 4 weeks postpartum to measure serum concentrations of ${\beta}$-hydroxybutyrate (BHBA), urea nitrogen, total cholesterol (TCH), albumin, aspartate aminotransferase (AST), calcium, and magnesium. PM was diagnosed by the presence of fever (${\geq}39.5^{\circ}C$) and a watery, fetid uterine discharge during the first 14 days after calving. Cows were divided into two groups on the basis of the presence or absence of the disease: a control group (n = 83) and a PM group (n = 67). The cows diagnosed with PM were subcutaneously administered with 2.2 mg/kg ceftiofur for 3-5 days. The serum concentrations of BHBA tended to be higher (P = 0.06) and AST was higher (P < 0.05) in the PM group than in the control group 1 week after calving, whereas serum concentrations of urea nitrogen, TCH, albumin, calcium, and magnesium were lower (P < 0.05-0.0001) after calving in the PM group than in the control group. The probability of clinical endometritis was higher (odds ratio = 5.40, P < 0.001) in the PM group than in the control group. Moreover, the proportion of neutrophils in the uterus was also higher in the PM group than in the control group 4, 6, and 8 weeks after calving (P < 0.001). The mean milk yield 1 and 2 months after calving was lower (P = 0.05) in the PM group than in the control group. The hazard of pregnancy by 180 days after calving tended to be lower (hazard ratio = 0.60, P = 0.07) in the PM group than in the control group, which led to an extended mean interval between calving and pregnancy (19 days) in the PM group (P < 0.01). In conclusion, PM is associated with higher postpartum concentrations of BHBA and AST, and lower concentrations of urea nitrogen, TCH, albumin, calcium, and magnesium. Moreover, PM is associated with subsequent poor uterine health, lower milk yield, and poorer reproductive performance in dairy cows.

Keywords

References

  1. Armengol R, Fraile L. Comparison of two treatment strategies for cows with metritis in high-risk lactating dairy cows. Theriogenology 2015; 83: 1344-1351. https://doi.org/10.1016/j.theriogenology.2015.01.024
  2. Bell MJ, Roberts DJ. The impact of uterine infection on a dairy cow's performance. Theriogenology 2007; 68: 1074-1079. https://doi.org/10.1016/j.theriogenology.2007.08.010
  3. Benzaquen ME, Risco CA, Archbald LF, Melendez P, Thatcher M-J, Thatcher WW. Rectal temperature, calvingrelated factors, and the incidence of puerperal metritis in postpartum dairy cows. J Dairy Sci 2007; 90: 2804-2814. https://doi.org/10.3168/jds.2006-482
  4. Bernabucci U, Ronchi B, Basirico L, Pirazzi D, Rueca F, Lacetera N, Nardone A. Abundance of mRNA of apolipoprotein B100, apolipoprotein E, and microsomal triglyceride transfer protein in liver from periparturient dairy cows. J Dairy Sci 2004; 87: 2881-2888. https://doi.org/10.3168/jds.S0022-0302(04)73418-9
  5. Burke CR, Meier S, McDougall S, Compton C, Mitchell M, Roche JR. Relationships between endometritis and metabolic state during the transition period in pasture-grazed dairy cows. J Dairy Sci 2010; 93: 5363-5373. https://doi.org/10.3168/jds.2010-3356
  6. Cai TQ, Weston PG, Lund LA, Brodie B, McKenna DJ, Wagner WC. Association between neutrophil functions and periparturient disorders in cows. Am J Vet Res 1994; 55: 934-943.
  7. Cebra CK, Garry FB, Getzy DM, Fettman MJ. Hepatic lipidosis in anoretic, lactating Holstein cattle: A retrospective study of serum biochemical abnormalities. J Vet Intern Med 1997; 11: 231-237. https://doi.org/10.1111/j.1939-1676.1997.tb00096.x
  8. Cook N, Oetzel G, Nordlund K. Modern techniques for monitoring high-producing dairy cows. 1. Principles of herdlevel diagnoses. In Pract 2006; 28: 510-515. https://doi.org/10.1136/inpract.28.9.510
  9. Drillich M, Beetz O, Pfutzner A, Sabin M, Sabin H-J, Kutzer P, Nattermann H, Heuwieser W. Evaluation of a systemic antibiotic treatment of toxic puerperal metritis in dairy cows. J Dairy Sci 2001; 84: 2010-2017. https://doi.org/10.3168/jds.S0022-0302(01)74644-9
  10. Dubuc J, Duffield TF, Leslie KE, Walton JS, LeBlanc SJ. Risk factors for postpartum uterine diseases in dairy cows. J Dairy Sci 2010; 93: 5764-5771. https://doi.org/10.3168/jds.2010-3429
  11. Dubuc J, Duffield TF, Leslie KE, Walton JS, LeBlanc SJ. Effects of postpartum uterine diseases on milk production and culling in dairy cows. J Dairy Sci 2011; 94: 1339-1346. https://doi.org/10.3168/jds.2010-3758
  12. Espadamala A, Pereira R, Pallares P, Lago A, Silva-del-Rio N. Metritis diagnosis and treatment practices in 45 dairy farms in California. J Dairy Sci 2018; 101: 9608-9616. https://doi.org/10.3168/jds.2017-14296
  13. Galvao KN, Flaminio MJBF, Brittin SB, Sper R, Fraga M, Caixeta L, Ricci A, Guard CL, Butler WR, Gilbert RO. Association between uterine disease and indicators of neutrophil and systemic energy status in lactating Holstein cows. J Dairy Sci 2010; 93: 2926-2937. https://doi.org/10.3168/jds.2009-2551
  14. Giuliodori MJ, Magnasco RP, Becu-Villalobos D, Lacau-Mengido IM, Risco CA, de la Sota RL. Metritis in dairy cows: Risk factors and reproductive performance. J Dairy Sci 2013; 96: 3621-3631. https://doi.org/10.3168/jds.2012-5922
  15. Goff JP, Horst RL. Physiological changes at parturition and their relationship to metabolic disorders. J Dairy Sci 1997; 80: 1260-1268. https://doi.org/10.3168/jds.S0022-0302(97)76055-7
  16. Gonzalez FD, Muino R, Pereira V, Campos R, Benedito JL. Relationship among blood indicators of lipomobilization and hepatic function during early lactation in high-yielding dairy cows. J Vet Sci 2011; 12; 251-255. https://doi.org/10.4142/jvs.2011.12.3.251
  17. Haimerl P, Heuwieser W. Invited review: Antibiotic treatment of metritis in dairy cows: A systematic approach. J Dairy Sci 2014; 97: 6649-6661. https://doi.org/10.3168/jds.2014-8462
  18. Hammon DS, Evjen IM, Dhiman TR, Goff JP, Walters JL. Neutrophil function and energy status in Holstein cows with uterine health disorders. Vet Immunol Immunopathol 2006; 113: 21-29. https://doi.org/10.1016/j.vetimm.2006.03.022
  19. Hayton A, Husband J, Vecqueray R. Nutritional management of herd health. In: Dairy Herd Health, Oxfordshire: CABI. 2012: 248.
  20. Herdt TH, Liesman JS, Gerloff BJ, Emery RS. Reduction of serum triacylglycerol-rich lipoprotein concentrations in cows with hepatic lipidosis. Am J Vet Res 1983; 44: 293-296.
  21. Huzzey JM, Veira DM, Weary DM, von Keyserlingk MAG. Prepartum behavior and dry matter intake identify dairy cows at risk for metritis. J Dairy Sci 2007; 90: 3220-3233. https://doi.org/10.3168/jds.2006-807
  22. Kasimanickam R, Duffield TF, Foster RA, Gartley CJ, Leslie KE, Walton JS, Johnson WH. Endometrial cytology and ultrasonography for the detection of subclinical endometritis in postpartum dairy cows. Theriogenology 2004; 62: 9-23. https://doi.org/10.1016/j.theriogenology.2003.03.001
  23. Kehrli ME Jr, Goff JP. Periparturient hypocalcemia in cows: effects on peripheral blood neutrophil and lymphocyte function. J Dairy Sci 1989; 72: 1188-1196. https://doi.org/10.3168/jds.S0022-0302(89)79223-7
  24. Kindahl H, Odensvik K, Aiumlamai S, Fredriksson G. Utero-ovarian relationships during the bovine postpartum period. Anim Reprod Sci 1992; 28: 363-369. https://doi.org/10.1016/0378-4320(92)90122-T
  25. Lima FS, Vieira-Neto A, Vasconcellos GSFM, Mingoti RD, Karakaya E, Sole E, Bisinotto RS, Martinez N, Risco CA, Galvao KN, Santos JEP. Efficacy of ampicillin trihydrate or caftiofur hydrochloride for treatment of metritis and subsequent fertility in dairy cows. J Dairy Sci 2014; 97: 5401-5414. https://doi.org/10.3168/jds.2013-7569
  26. Mahnani A, Sadeghi-Sefidmazgi A, Cabrera VE. Consequences and economics of metritis in Iranian Holstein dairy farms. J Dairy Sci 2015; 98: 6048-6057. https://doi.org/10.3168/jds.2014-8862
  27. Martinez N, Risco CA, Lima FS, Bisinotto RS, Greco LF, Ribeiro ES, Maunsell F, Galvao K, Santos JEP. Evaluation of peripartal calcium status, energetic profile, and neutrophil function in dairy cows at low or high risk of developing uterine disease. J Dairy Sci 2012; 95: 7158-7172. https://doi.org/10.3168/jds.2012-5812
  28. Mateus L, Lopes da Costa L, Bernardo F, Robalo Silva J. Influence of puerperal uterine infection on uterine involution and postpartum ovarian activity in dairy cows. Reprod Dom Anim 2002; 37: 31-35. https://doi.org/10.1046/j.1439-0531.2002.00317.x
  29. McDougall S, Macaulay R, Compton C. Association between endometritis diagnosis using a novel intravaginal device and reproductive performance in dairy cattle. Anim Reprod Sci 2007; 99: 9-23. https://doi.org/10.1016/j.anireprosci.2006.03.017
  30. National Research Council. Mineral tolerance of animals, seventh ed. Washington, DC: National Academy Press. 2005.
  31. Piccardi M, Romero G, Veneranda G, Castello E, Romero D, Balzarini M, Bo GA. Effect of puerperal metritis on reproductive and productive performance in dairy cows in Argentina. Theriogenology 2016; 85: 887-893. https://doi.org/10.1016/j.theriogenology.2015.10.038
  32. Ribeiro ES, Gomes G, Greco LF, Cerri RLA, Vieira-Neto A, Monteiro Jr PLJ, Lima FS, Bisinotto RS, Thatcher WW, Santos JEP. Carryover effect of postpartum inflammatory diseases on developmental biology and fertility in lactating dairy cows. J Dairy Sci 2016; 99: 2201-2220. https://doi.org/10.3168/jds.2015-10337
  33. Sheldon IM, Dobson H. Postpartum uterine health in cattle. Anim Reprod Sci 2004; 82-83; 295-306. https://doi.org/10.1016/j.anireprosci.2004.04.006
  34. Sheldon IM, Lewis GS, LeBlanc S, Gilbert RO. Defining postpartum uterine disease in cattle. Theriogenology 2006; 65: 1516-1530. https://doi.org/10.1016/j.theriogenology.2005.08.021
  35. Urton G, von Keyserlingk MAG, Weary DM. Feeding behavior identifies dairy cows at risk for metritis. J Dairy Sci 2005; 88: 2843-2849. https://doi.org/10.3168/jds.S0022-0302(05)72965-9
  36. Vazquez-Anon M, Bertics S, Luck M, Grummer RR, Pinheiro J. Peripartum liver triglyceride and plasma metabolites in dairy cows. J Dairy Sci 1994; 77: 1521-1528. https://doi.org/10.3168/jds.S0022-0302(94)77092-2
  37. West HJ. Effect of on liver function of acetonaemia and the fat cow syncrome in cattle. Res Vet Sci 1990; 48: 221-227. https://doi.org/10.1016/S0034-5288(18)30994-9
  38. Wittrock JM, Proudfoot KL, Weary DM, von Keyserlingk MAG. Short communication: Metritis affects milk production and cull rate of Holstein multiparous and primiparous dairy cows differently. J Dairy Sci 2011; 94: 2408-2412. https://doi.org/10.3168/jds.2010-3697