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Anti-wrinkle efficacy of isoquercitrin isolated from Nymphoides indica

어리연꽃에서 분리된 Isoquercitrin의 주름개선 효능 연구

  • Yu, Jae-Myo (Department of Korean Medicine Development, National Development Institute of Korean Medicine) ;
  • Kang, Yun-Hwan (Department of Korean Medicine Development, National Development Institute of Korean Medicine) ;
  • Kim, Dong-Hee (Department of Korean Medicine Development, National Development Institute of Korean Medicine) ;
  • Kim, You-Ah (Skin Science Research Institute, Kolmar Korea Co., Ltd.) ;
  • Kim, A-Hyun (Skin Science Research Institute, Kolmar Korea Co., Ltd.) ;
  • Park, Byoung-Jun (Skin Science Research Institute, Kolmar Korea Co., Ltd.) ;
  • Park, Tae-Soon (Department of Korean Medicine Development, National Development Institute of Korean Medicine)
  • Received : 2018.10.01
  • Accepted : 2018.10.11
  • Published : 2018.12.31

Abstract

In this study, we evaluated the possibility of wrinkle-reducing functional cosmetic material of isoquercitrin (IQC) isolated from Nymphoides indica (NP) by measuring the efficacy of ROS inhibition, procollagen synthesis induction, and matrix metalloproteinase (MMP)-1 inhibition. As a result, ROS tended to be inhibited in a concentration dependent manner, and the procollagen protein synthesis rate was increased by 70% ($5{\mu}g/mL$) and the MMP-1 protein was decreased by 41% ($5{\mu}g/mL$) compared with the control. This was suggested the ability of IQC to induce the procollagen synthesis and to reduce the ROS and MMP-1 production. Therefore, it is considered that IQC isolated from NP has enough value to be a functional cosmetic material.

본 연구에서는 어리연꽃에서 분리된 isoquercitrin (IQC)를 이용하여 ROS 활성 억제, procollagen 합성유도, MMP-1의 발현억제를 측정함으로써 주름개선 기능성 화장품 원료로서의 가능성을 평가하였다. 그 결과, ROS는 농도의존적으로 억제하는 경향을 나타내었고 procollagen protein 합성증가율은 대조군과 비교하여 70% ($5{\mu}g/mL$), MMP-1 protein은 41% ($5{\mu}g/mL$)의 억제 활성을 보여주었다. 이것으로 IQC의 procollagen 합성유도능과 ROS 및 MMP-1의 강력한 저해효과를 확인 할 수 있었다. 따라서 어리연꽃에서 분리된 IQC는 기능성 화장품 소재로 할 충분한 가치가 있다고 사료된다.

Keywords

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