Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Effect of Sasa quelpaertensis Nakai Extracts and its Constituent p-coumaric Acid on the Apoptosis of Human Cancer Cell Lines

  • Jang, Mi Gyeong (Department of Biology, Jeju National University) ;
  • Ko, Hee Chul (Jeju Sasa Industry Development Agency, Jeju National University) ;
  • Kim, Se Jae (Jeju Sasa Industry Development Agency, Jeju National University)
  • Received : 2018.05.31
  • Accepted : 2018.07.17
  • Published : 2018.12.31
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Abstract

Sasa quelpaertensis Nakai leaves contain a mixture of polysaccharides, amino acids, and polyphenols, which mediate various biological activities. For efficient utilization of its leaf, we reported the preparation procedure for phytochemical-rich extract (PRE) using the leaf residue, which was by-product of hot water extraction. This study was undertaken to evaluate the effects of PRE and its major constituent, p-coumaric acid,on the growth of several human cancer cell lines (MKN-74, MKN-45, SNU-1, SNU-16, and HL-60). The ethyl acetate fraction of PRE and p-coumaric acid significantly inhibited the proliferation of MKN-74 and HL-60 cells, respectively, and induced cell apoptosis, down-regulated Bcl-2 and poly (ADP-ribose) polymerase levels, and up-regulated those of Bax and caspase-3. These results show the potential utility of S. quelpaertensis Nakai leaves in cancer prevention.

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References

  1. Doll, R. Cancer Res. 1992, 52, 2024S-2029S.
  2. Jemal, A.; Bray, F.; Center. M. M.; Ferlay, J.; Ward, E.; Forman, D. CA Cancer J. Clin. 2011, 61, 69-90. https://doi.org/10.3322/caac.20107
  3. Kim, E. J.; Part, H.; Lim, S. S.; Kim, J. S.; Shin, H. K.; Yoon, J. H. Korean J. Food Sci. Technol. 2008, 40, 207-214.
  4. Fulda, S.; Debatin, K. M. Curr. Cancer Drug Targets. 2004, 7, 569-576.
  5. Ji, Y. B.; Qu, Z. Y.; Zou. X. Exp. Toxicol. Pathol. 2011, 63, 69-78. https://doi.org/10.1016/j.etp.2009.09.010
  6. Shinkai, K.; Akedo, H.; Mukai, M.; Imamura, F.; Isoai, A.; Kobayashi, M.; Kitagawa, I. Jpn. J. Cancer Res. 1996, 87, 357-362. https://doi.org/10.1111/j.1349-7006.1996.tb00230.x
  7. Ahmad, N.; Feyes, D. K.; Nieminen, A. L.; Agarwal, R.; Mukhtar H. J. Natl. Cancer Inst. 1997, 89, 1881-1886. https://doi.org/10.1093/jnci/89.24.1881
  8. Hwang, J. H.; Choi, S. Y.; Ko, H. C.; Jang, M. G.; Jin, Y. J.; Kang, S. I.; Park, J. G.; Chung, W. S.; Kim, S. J. Food Sci. Biotechnol. 2007, 16, 728-733.
  9. Jang, M. G.; Park, S. Y.; Lee, S. R.; Choi, S. Y.; Hwang, J. H.; Ko, H. C.; Park, J. G.; Chung, W. S.; Kim, S. J. Food Sci. Biotechnol. 2008, 17, 188-190.
  10. Kim, M.; Kim, Y. S.; Kim, K. M.; Ko, H. C.; Kim, S. J.; Kim, J. H.; Kim, Y. Integr. Cancer Ther. 2014, 13, 529-540. https://doi.org/10.1177/1534735414534462
  11. Kim, A.; Bing, S. J.; Cho, J.; Herath, K.; Ahn, G.; Park, E.; Kim, M. J.; Kim, D. S.; Kim, J. S.; Lee, N. H.; Jee, Y. J. Prev. Vet. Med. 2015, 39, 169-174. https://doi.org/10.13041/jpvm.2015.39.4.169
  12. Lee, J. Y.; Ko, H. C.; Jang, M. G.; Kim, S. J. J. Life Sci. 2016, 26, 1330-1335. https://doi.org/10.5352/JLS.2016.26.11.1330
  13. Kang, S. W.; Kang, S. I.; Shin, H. S.; Yoon, S. A.; Kim, J. H.; Ko, H. C.; Kim, S. J. Food Chem. Toxicol. 2013, 59, 380-385. https://doi.org/10.1016/j.fct.2013.06.033
  14. Kim, A.; Bing, S. J.; Cho, J.; Herath, K.; Ahn, G.; Park, E.; Kim, M. J.; Kim, D. S.; Kim, J. S.; Lee, N. H.; Jee, Y. J. Prev. Vet. Med. 2016, 39, 169-174.
  15. Janicke, B.; Onning, G.; Oredsson, S. M. J. Agric. Food Chem. 2005, 53, 6658-6665. https://doi.org/10.1021/jf050489l
  16. Jaganathan, S. K.; Supriyanto, E.; Mandal, M. World J. Gastroenterol. 2013, 19, 7726-7734. https://doi.org/10.3748/wjg.v19.i43.7726
  17. Liu, M. H.; Ko, C. H.; Ma, N.; Tan, P. W.; Fu, W. M.; He, J. Y. J. Funct. Foods 2016, 22, 533-546. https://doi.org/10.1016/j.jff.2016.02.010
  18. Hunt, A.; Evan, G. Science 2001, 293, 1784-1785. https://doi.org/10.1126/science.1065206
  19. Burlacu, A. J. Cell. Mol. Med. 2003, 7, 249-257. https://doi.org/10.1111/j.1582-4934.2003.tb00225.x
  20. Kuwana, T.; Mackey, M. R.; Perkins, G.; Ellisman, M. H.; Latterich, M.; Schneiter, R.; Green, D. R.; Newmeyer, D. D. Cell 2002, 111, 331-342. https://doi.org/10.1016/S0092-8674(02)01036-X
  21. Green, D. R.; Reed, J. C. Science 1998, 281, 1309-1312. https://doi.org/10.1126/science.281.5381.1309
  22. Fernandes-Alnemri, T.; Litwack, G.; Alnemri, E. S. J. Biol. Chem. 1994, 269, 30761-30764.

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