Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Acronyculatin P, A New Isoprenylated Acetophenone from the Stem Bark of Acronychia pedunculata

  • Tanjung, Mulyadi (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga) ;
  • Nurmalasari, Intan (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga) ;
  • Wilujeng, Aisyah Kanti (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga) ;
  • Saputri, Ratih Dewi (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga) ;
  • Rachmadiarti, Fida (Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Surabaya) ;
  • Tjahjandarie, Tjitjik Srie (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga)
  • Received : 2018.05.31
  • Accepted : 2018.08.18
  • Published : 2018.12.31
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Abstract

A new isoprenylated acetophenone, acronyculatin P (1) as well as two known compounds, 3',5'-diisoprenyl-2',4'-dihydroxy-6'-methoxyphenylethanone (2) and 3'-isoprenyl-2',4',6'-trihydroxyphenylethanone (3) were isolated from the stem bark of Acronychia pedunculata (L.) Miq. The structures were determined by HRESIMS, 1D and 2D NMR. The inhibitory activity of the isoprenylated acetophenone derivatives against murine leukemia P-388 cells showed compound 1 moderate activity with $IC_{50}$ $15.42{\mu}M$.

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Acknowledgement

Supported by : Universitas Airlangga

References

  1. Hartley, T. G. J. Arnold Arbor. 1974, 55, 469-523.
  2. de Silva, L. B.; de Silva, U. L. L.; Mahendran, M.; Jenings, R. M. Phytochem. 1979, 18, 1255-1256. https://doi.org/10.1016/0031-9422(79)80162-4
  3. De Silva, L. B.; Herath, W. M.; Liyanage, C.; Kumar, V.; Ahmad, V. U.; Sultana, A. Phytochem. 1991, 30, 1709-1710. https://doi.org/10.1016/0031-9422(91)84240-S
  4. Kozaki, S.; Takenaka, Y.; Mizushina, Y.; Yamaura, T.; Tanahashi, T. J. Nat. Med. 2014, 68, 421-426. https://doi.org/10.1007/s11418-013-0803-y
  5. Kouloura, E.; Halabalaki, M.; Lallemand, M. C.; Nam, S.; Jove, R.; Litaudon, M.; Awang, K.; Hadi, H. A.; Skaltsounis. A. L. J. Nat. Prod. 2012, 75, 1270-1276. https://doi.org/10.1021/np201007a
  6. Pathmasiri, W.; el-Seedi, H. R.; Han, X.; Janson, J. C.; Huss, U.; Bohlin, L. Chem. Biodivers. 2005, 2, 463-469. https://doi.org/10.1002/cbdv.200590026
  7. Su, C. R.; Kuo, P. C.; Wang, M. L.; Liou, M. J.; Damu, A. G.; Wu, T. S. J. Nat. Prod. 2003, 66, 990-993. https://doi.org/10.1021/np030054x
  8. Tanjung, M.; Rachmadiarti, F.; Saputri, R. D.; Tjahjandarie, T. S. Nat. Prod. Res. 2018, 32, 1062-1067. https://doi.org/10.1080/14786419.2017.1378215
  9. Tanjung, M.; Hakim, E. H.; Syah, Y. M. Chem Nat Compd. 2017, 53, 215-218. https://doi.org/10.1007/s10600-017-1955-x
  10. Marliana, E.; Astuti, W.; Kosala, K.; Hairani, R.; Tjahjandarie, T. S.; Tanjung, M. Asian J. Chem. 2018, 30, 795-798. https://doi.org/10.14233/ajchem.2018.21004
  11. Tanjung, M.; Saputri, R. D.; Tjahjandarie, T. S. Molbank. 2016, M906, 3, 1-5. https://doi.org/10.3390/M906
  12. Han, X.; Pathmasiri,W.; Bohlin, L.; Janson, J. C. J. Chromatogr. A. 2004, 1022, 213-216. https://doi.org/10.1016/j.chroma.2003.09.046
  13. Basabe, P.; de Roman, M.; Marcos, I. S.; Diez, D.; Blanco, A.; Bodero, O.; Mollinedo, F.; Sierra, B. G.; Urones, J. G. Eur. J. Med. Chem. 2010, 45, 4258-4269. https://doi.org/10.1016/j.ejmech.2010.06.025