Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
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Development of Research into Autophagic Lysosome Reformation

  • Chen, Yang (State Key Laboratory of Membrane Biology, Tsinghua University-Peking University Joint Center for Life Sciences, School of Life Sciences, Tsinghua University) ;
  • Yu, Li (State Key Laboratory of Membrane Biology, Tsinghua University-Peking University Joint Center for Life Sciences, School of Life Sciences, Tsinghua University)
  • Received : 2017.10.23
  • Accepted : 2017.11.30
  • Published : 2018.01.31
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Abstract

Autophagy is a lysosome-dependent degradation process that is essential for maintaining cellular homeostasis. In recent years, more studies have focused on the late stages of autophagy. Our group discovered and studied the terminal step of autophagy, namely autophagic lysosome reformation (ALR). ALR is the process that regenerates functional lysosomes from autolysosomes, thus maintaining lysosome homeostasis. ALR involves clathrin-mediated membrane budding from autolysosomes, elongation of membrane tubules along microtubules with the pulling force provided by the motor protein KIF5B, proto-lysosome scission by dynamin 2, and finally maturation of proto-lysosomes to functional lysosomes. In this review, we will summarize progress in unveiling the molecular mechanisms underlying ALR and its potential pathophysiological roles.

Keywords

E1BJB7_2018_v41n1_45_f0001.png 이미지

Fig. 1. Schematic illustration of the correlation between mTORactivity and autophagy during starvation.

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Fig. 2. Schematic illustration of the process of ALR involving clathrin-mediated membrane budding from autolysosomes, elongation ofmembrane tubules along microtubules by the motor protein KIF5B and proto-lysosome scission by dynamin 2.

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