FIG. 1. Experimental setup of the CWNIRS system used for monitoring tumor hemodynamics.
FIG. 2. Protocol of inhaled-gas intervention.
FIG. 3. (a) Representative set of data showing oxyhemoglobin (OHb), deoxyhemoglobin (RHb), pulmonary oxygen saturation (SpO2), and heart rate (HR) during the inhaled-gas interventions. (b) A double-exponential equation (Eq. (1)) was fitted to the change of OHb concentration during hyperoxia. Amplitude 1 (A1) corresponds mainly to hemodynamics in the well-perfused region of the tumor, while Amplitude 2 (A2) corresponds to the poorly perfused region.
FIG. 4. The changes of A1 and A2 values and tumor-volume change from (a) the control group (n = 6), (b) chemo group (n = 6), and (c) early chemo group (n = 6). A1(t) and A2(t) represent amplitude values from the tumor breast, while A1(c) and 2(c) represent amplitude values from the contralateral normal breast.
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