Journal of Food Hygiene and Safety (한국식품위생안전성학회지)

The Korean Society of Food Hygiene and Safety (한국식품위생안전성학회)
권호 표지
DOI QR코드

DOI QR Code

A Study on the Safety of Commercial Wet Tissues

유통 중인 물휴지의 안전성 조사 연구

  • Bae, Ho-Jeong (Pharmaceutical Chemistry Team, Gyeonggi-Do Institute of Health and Environment) ;
  • Jung, Hong-Rae (Pharmaceutical Chemistry Team, Gyeonggi-Do Institute of Health and Environment) ;
  • Lee, So-Hyun (Pharmaceutical Chemistry Team, Gyeonggi-Do Institute of Health and Environment) ;
  • Lee, Seong-Bong (Pharmaceutical Chemistry Team, Gyeonggi-Do Institute of Health and Environment) ;
  • Song, Seo-Hyeon (Pharmaceutical Chemistry Team, Gyeonggi-Do Institute of Health and Environment) ;
  • Hong, Mi-Yeon (Pharmaceutical Chemistry Team, Gyeonggi-Do Institute of Health and Environment) ;
  • Kim, Beom-Ho (Pharmaceutical Chemistry Team, Gyeonggi-Do Institute of Health and Environment) ;
  • Park, Gwang-Hee (Pharmaceutical Chemistry Team, Gyeonggi-Do Institute of Health and Environment) ;
  • Yoon, Mi-Hye (Pharmaceutical Chemistry Team, Gyeonggi-Do Institute of Health and Environment)
  • 배호정 (경기도보건환경연구원 약품화학팀) ;
  • 정홍래 (경기도보건환경연구원 약품화학팀) ;
  • 이소현 (경기도보건환경연구원 약품화학팀) ;
  • 이성봉 (경기도보건환경연구원 약품화학팀) ;
  • 송서현 (경기도보건환경연구원 약품화학팀) ;
  • 홍미연 (경기도보건환경연구원 약품화학팀) ;
  • 김범호 (경기도보건환경연구원 약품화학팀) ;
  • 박광희 (경기도보건환경연구원 약품화학팀) ;
  • 윤미혜 (경기도보건환경연구원 약품화학팀)
  • Received : 2017.05.31
  • Accepted : 2018.01.11
  • Published : 2018.02.28
Download PDF
⟨ Previous Next ⟩

Abstract

The purpose of this study was to investigate and evaluate the safety of the wet tissues. In this study, we analyzed sterilizing preservatives and the presence of harmful substances in 62 wet tissue samples in the market. The contents of preservatives, formaldehyde and methanol were analyzed by HPLC and headspace-GC, respectively. Cetylpyridinium chloride was detected as 7-13 ppm in 5 samples. Sodium benzoate was detected in 46 samples ranging from 200 ppm to 3500 ppm, and 9 ppm of methylparahydroxy benzoate was detected in 1 sample. Propylparahydroxy benzoate was not detected in any samples. 5 ppm of methylchloroisothiazolinone and 140 ppm of methylisothiazolinone were detected in 1 sample. Formaldehyde was detected as $0.0069-1.796{\mu}g/g$ in 59 samples. Methanol was detected ranging from 2 ppm to 51 ppm in 22 samples, and 4 samples showed more than 20 ppm of the legal limit. The pH of the wet tissues was 4.0 to 8.2. Continuous investigation and monitoring are necessary to ensure safe distribution of products.

시중에 유통 중인 물휴지 62 품목을 선정하여 살균보존제 성분 및 유해물질 함유 여부 등의 안전성을 조사하였다. 일반적으로 화장품 및 식품에 가장 많이 사용하는 살균 보존제인 안식향산나트륨은 46 품목에서 200~3500 ppm 검출되었고 파라벤류는 1 품목에서 파라옥시안식향산메칠이 9 ppm 검출되었다. 사용할 수 없는 살균보존제인 메칠클로로이소치아졸리논과 메칠이소치아졸리논(3:1)혼합물이 1 품목에서 검출되어 부적합 판정되었으며, 메칠클로로이소치아졸리논 5 ppm, 메칠이소치아졸리논 140 ppm 검출되었다. 염화세틸피리디늄은 5 품목에서 7~13 ppm 검출되었으며, 모두 허용기준 이내로 나타났다. 잔류유해물질인 포름알데히드 검사결과는 $0.069{\sim}1.796{\mu}g/g$로 허용기준인 $20{\mu}g/g$ 이하였다. 메탄올은 5~51 ppm 검출되었으며, 이 중 4 품목에서 허용기준인 20 ppm보다 2배 이상의 농도가 나타났다. 안전한 제품이 유통될 수 있도록 메탄올의 잔류경로에 대한 지속적인 조사 및 모니터링이 필요하다고 판단된다. 물휴지의 pH를 측정한 결과 4.0~8.2로 나타나 유통화장품의 pH 3.0~9.0 기준에 적합하였으나, 물휴지에는 pH 기준이 설정되어 있지 않으므로 안전관리를 위해서는 pH 기준을 설정하는 고시개정이 필요할 것이다.

Keywords

References

  1. Cosmetic Industry Analysis Report: Korea Health Industry Development Institute, (2015).
  2. Yoo H.J., Hwang H.S.: Use pattern and safety pursuit behavior of consumers who using wet wipes for infants. Crisisonomy, 10(9), 49-73 (2014).
  3. Park J.E., Lee S.M., Jeong H.J., Chang I.S.: Simultaneous determination of 8 preservativers (6 parabens, 2-phenoxyethanol, and chlorphenesin) in cosmetics by UPLCTM. J.Soc. Cosmet. Scientists Korea, 33(4), 263-267 (2007).
  4. Darbre P.D., Byford J.R., Shaw L.E., Horton R.A., Pope G.S., Sauer, M.J.: Oestrogenic activity of isobutylparaben in vitro and in vivo. J. Appl. Toxicol., 28, 561-567 (2002).
  5. Mizuno H., Hirai H., Kawai S., Nishida T.: Removal of estrogenic acitivity of iso-butylparaben and n-butylparaben by laccase in the presence of 1-hydroxybenzotriazole. Biodegradation 20, 533-539 (2009). https://doi.org/10.1007/s10532-008-9242-y
  6. Korea Food & Drug Administration: A study on the development of analysis method of ingredients in cosmetics-UV filter ingredients and preservative ingredients. NIFDS research and service report. (2012).
  7. Ministry of Food and Drug Safety: Exposure factor development study for exposure assessment of household productcleaner and wet-tissue. KFDA research and service report. (2014).
  8. AOAC: Peer verifided methods program AOAC. Manual on Polices Procedures, USA, (2011).
  9. ICH Steering Committee: European agency for the evaluation of medicinal products, international commission on harmonisation. ICH Q2B Validation of Analytical Procedures: methodology, London (CPMP/ICH/281/95) (1996).
  10. Shabir, G.A.: Validation of high-performance liquid chromatography methods for pharmaceutical analysis: Understanding the differences and similarities between validation requirements of the US Food and Drug Administration, the US Pharmacopeia and the international conference on harmonization. J. Chromatogr. A, 987(1), 57-66 (2003). https://doi.org/10.1016/S0021-9673(02)01536-4
  11. Park J.S., Hwang L.H., Yang H.R., Jung S.Y., Kim N.Y., Park S.H., Chae H.S., Cho S.J., Lee S.M., Kim J.H.: Monitoring of preservatives in personal care products. Report of S.I.H.E., 50, 61-71 (2014).
  12. Kim C.K., Choi B.K., Yoo Y.J., Kim S.N., Seok J.K., Kim M.M.: In vitro antibacterial effect of a mouthrinse containing CPC (Cetylpyridinium Chloride), NaF and UDCA (Ursodexoycholic acid) against major periodontopathogens. J. Periodontal Implant Sci., 29(2), 325-333 (1999).
  13. Ministry of Food and Drug Safety: Analysis of harmful substances in cosmetics (II)-Methanol Analysis (2012).
  14. Ministry of Food and Drug Safety: Analysis of harmful substances in cosmetics (III)-Formaldehyde Analysis (2012).
  15. Jung H.H.: A study on the effect of fundamental cosmetics on pH level of the skin after use of slightly acid and alkalescent cleansers. Graduate School of Engineering Konkuk University (2015).