Journal of Korean Neurosurgical Society

The Korean Neurosurgical Society (대한신경외과학회)
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Curcumin Increase the Expression of Neural Stem/Progenitor Cells and Improves Functional Recovery after Spinal Cord Injury

  • Bang, Woo-Seok (Department of Neurosurgery, Kyungpook National University Hospital) ;
  • Kim, Kyoung-Tae (Department of Neurosurgery, Kyungpook National University Hospital) ;
  • Seo, Ye Jin (Department of Neurosurgery, Kyungpook National University Hospital) ;
  • Cho, Dae-Chul (Department of Neurosurgery, Kyungpook National University Hospital) ;
  • Sung, Joo-Kyung (Department of Neurosurgery, Kyungpook National University Hospital) ;
  • Kim, Chi Heon (Department of Neurosurgery, Seoul National University Hospital)
  • Received : 2017.03.08
  • Accepted : 2017.05.31
  • Published : 2018.01.01
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Abstract

Objective : To investigates the effect of curcumin on proliferation of spinal cord neural stem/progenitor cells (SC-NSPCs) and functional outcome in a rat spinal cord injury (SCI) model. Methods : Sixty adult male Sprague-Dawley rats were randomly and blindly allocated into three groups (sham control group; curcumin treated group after SCI; vehicle treated group after SCI). Functional recovery was evaluated by the Basso, Beattie, and Bresnahan (BBB) scale during 6 weeks after SCI. The expression of SC-NSPC proliferation and astrogliosis were analyzed by nestin/Bromodeoxyuridine (BrdU) and Glial fibrillary acidic protein (GFAP) staining. The injured spinal cord was then examined histologically, including quantification of cavitation. Results : The BBB score of the SCI-curcumin group was better than that of SCI-vehicle group up to 14 days (p<0.05). The coimmunoreactivity of nestin/BrdU in the SCI-curcumin group was much higher than that of the SCI-vehicle group 1 week after surgery (p<0.05). The GFAP immunoreactivity of the SCI-curcumin group was remarkably lower than that of the SCI-vehicle group 4 weeks after surgery (p<0.05). The lesion cavity was significantly reduced in the curcumin group as compared to the control group (p<0.05). Conclusion : These results indicate that curcumin could increase the expression of SC-NSPCs, and reduce the activity of reactive astrogliosis and lesion cavity. Consequently curcumin could improve the functional recovery after SCI via SC-NSPC properties.

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References

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