The Journal of the Korean dental association (대한치과의사협회지)

The Korean Dental Association (대한치과의사협회)
권호 표지

Regenerative medicine using dental tissue derived induced pluripotent stem cell-biomaterials complex

구강조직유래 유도만능줄기세포-생체재료 복합체의 재생의료 동향

  • Jun, Soo-Kyung (Department of Biomaterials Science, College of Dentistry, Dankook University) ;
  • Lee, Hae-Hyoung (Department of Biomaterials Science, College of Dentistry, Dankook University) ;
  • Kim, Hae-Won (Department of Biomaterials Science, College of Dentistry, Dankook University) ;
  • Lee, Jung-Hwan (Department of Biomaterials Science, College of Dentistry, Dankook University)
  • 전수경 (단국대학교 생체재료학교실) ;
  • 이해형 (단국대학교 생체재료학교실) ;
  • 김해원 (단국대학교 생체재료학교실) ;
  • 이정환 (단국대학교 생체재료학교실)
  • Received : 2017.07.18
  • Accepted : 2017.09.01
  • Published : 2017.12.01
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Abstract

In recent years, many researchers and clinicians found interest in regenerative medicine using induced pluripotent stem cells (iPSCs) with biomaterials due to their pluripotency, which is able to differentiate into any type of cells without human embryo, which of use is ethically controversial. However, there are limitations to make iPSCs from adult somatic cells due to their low stemness and donor site morbidity. Recently, to overcome above drawbacks, dental tissue-derived iPSCs have been highlighted as a type of alternative sources for their high stemness, easy gathering, and their complex (ectomesenchymal) origin, which easily differentiate them to various cell types for nerve, vessel, and other dental tissue regeneration. In other part, utilizing biomaterials for regenerative medicine using cell is recently highlighted because they can modulate cell adhesion, proliferation and (de)differentiation. Therefore, this paper will convey the overview of advantages and drawbacks of dental tissue-derived iPSCs and their future application with biomaterials.

Keywords

Acknowledgement

Supported by : National Research Foundation of Korea (NRF)

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