Journal of Preventive Medicine and Public Health

  • 제50권6호
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  • Pages.369-376
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  • 2017
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  • 1975-8375(pISSN)
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  • 2233-4521(eISSN)
대한예방의학회 (The Korean Society for Preventive Medicine)
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Are Serum Vitamin D Levels Associated With Dry Eye Disease? Results From the Study Group for Environmental Eye Disease

  • Jeon, Da-Hye (Department of Preventive Medicine, Yonsei University College of Medicine) ;
  • Yeom, Hyungseon (Department of Preventive Medicine, Yonsei University College of Medicine) ;
  • Yang, Jaewon (Department of Public Health, Yonsei University Graduate School) ;
  • Song, Jong Suk (Department of Ophthalmology, Korea University College of Medicine) ;
  • Lee, Hyung Keun (Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine) ;
  • Kim, Hyeon Chang (Department of Preventive Medicine, Yonsei University College of Medicine)
  • 투고 : 2017.06.07
  • 심사 : 2017.10.20
  • 발행 : 2017.11.30
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초록

Objectives: Dry eye disease (DED) is an increasingly important public health problem in Korea. Previous studies conducted in Korea have reported inconsistent results regarding the protective effects of vitamin D on DED, and these discrepancies may be related to the relatively simple questionnaire that has been used. Thus, we evaluated the association of serum vitamin D levels with DED using the ocular surface disease index (OSDI). Methods: The present study evaluated data from participants in the Study Group for Environmental Eye Disease (2014-2015). This group included data from 752 participants, and data from 740 participants (253 men and 487 women) were analyzed in the present study. DED severity was evaluated using the OSDI. Results: Higher serum vitamin D levels were associated with a non-significantly reduced risk of DED in the crude analysis (odds ratio [OR], 0.991; 95% confidence interval [CI], 0.971 to 1.011) and in the adjusted analysis (OR, 0.988; 95% CI, 0.966 to 1.010). In the crude analysis of no/mild DED vs. moderate/severe DED, men exhibited a decreased risk with increasing serum vitamin D levels (OR, 0.999; 95% CI, 0.950 to 1.051), while women exhibited an increased risk (OR, 1.003; 95% CI, 0.979 to 1.027). In these analyses, we found no significant associations. Conclusions: The findings of the present study support previous reports that serum vitamin D levels are not associated with DED.

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참고문헌

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피인용 문헌

  1. Nutrition and dry eye: a systematic review vol.14, pp.3, 2017, https://doi.org/10.1080/17469899.2019.1614442
  2. Vitamin D deficiency is associated with dry eye syndrome: a systematic review and meta‐analysis vol.98, pp.8, 2020, https://doi.org/10.1111/aos.14470
  3. Genistein‐Calcitriol Mitigates Hyperosmotic Stress‐Induced TonEBP, CFTR Dysfunction, VDR Degradation and Inflammation in Dry Eye Disease vol.14, pp.1, 2017, https://doi.org/10.1111/cts.12858