DOI QR코드

DOI QR Code

Effects of Capsosiphon Fulvescens Extract on Contact Dermatitis in NC/Nga Mice

매생이(莓山苔) 추출물이 NC/Nga 마우스의 접촉성 피부염에 미치는 효과

  • Eom, Ye-Jin (Dept. of Korean Medicine Ophthalmology & Otolaryngology & Dermatology, College of Korean Medicine, Sangji University) ;
  • Hong, Chul-Hee (Dept. of Korean Medicine Ophthalmology & Otolaryngology & Dermatology, College of Korean Medicine, Sangji University)
  • 엄예진 (상지대학교 한의과대학 한방안이비인후피부과학교실) ;
  • 홍철희 (상지대학교 한의과대학 한방안이비인후피부과학교실)
  • Received : 2017.09.28
  • Accepted : 2017.11.13
  • Published : 2017.11.25

Abstract

Objectives : The aim of this study is to report the effect of Capsosiphon fulvescens(Maesangi) extract(MSE) on contact dermatitis(CD). Methods : CD induced by Dermatophagoides farinae body(Dfb) in NC/Nga mice. 4% sodium dodecyl sulfate(SDS) $150{\mu}l$ and Dfb(10mg/ml) ointment 100mg were topically treated twice a week for four weeks. MSE 200 mg/kg was topically treated every 4weeks. Every week, we examined the skin lesions, weight of spleen and lymph node, epidermal thickness, production of Tumor necrosis factor-alpha($TNF-{\alpha}$) and interleukin-6(IL-6). Results : MSE reduced features of Dfb-induced skin lesions, weight of spleen and production of $TNF-{\alpha}$. MSE significantly reduced weight of lymph node, epidermal thickness, number of mast cells and production of IL-6. Conclusions : MSE may have a potential therapeutic effects for CD by suppressing allergic inflammation.

Keywords

References

  1. Dept. of Dermatology, Seoul national university college of medicine. Dermatology for medical student. 3rd ed. Seoul:Korea medical Book P. 2011:3144.
  2. Yu HJ. Inhibitory effect on the melanogenesis of ethanol extract of Capsosiphon fulvescens. PhD Dissertation. Wonkwang University. 2004.
  3. Yang HC, Jung KM, Gang KS, Song BJ, Lim HC, Na HS, et al. Physicochemical Composition of Seaweed Fulvescens (Capsosiphon fulvescens). Kor J Food Sci Technol. 2005;37(6):912-7.
  4. Jung KJ, Jung CH, Pyeun JH, Choi YJ. Changes of Food Components in Mesangi(Capsosiphon fulvecense), Gashiparae (Enteromorpha prolifera), and Cheonggak (Codium fragile) Depending on Harvest Times. J Korean Soc Food Sci Nutr. 2005;34(5):687-93. https://doi.org/10.3746/jkfn.2005.34.5.687
  5. Park HY, Lim CW, Kim YK, Yeon HD, Lee KJ. Immunostimulating and anticancer activities of hot water extract from Capsosiphon fulvescens. J Korean Soc Applied Biological Chemistry. 2006;49(4): 343-8.
  6. Mun YJ, Yoo HJ, Lee KE, Kim JH, Pyo HB, Woo WH. Inhibitory Effect on the Melanogenesis of Capsosiphon fulvescens. Yakhak Hoeji. 2005;49(5):375-9.
  7. Park MH, Kim M. Effect of Capsosiphon fulvescens extract on collagen content of connective tissues in ovariectomized rats. J Life Sci. 2006;16:1219-24. https://doi.org/10.5352/JLS.2006.16.7.1219
  8. Jeong KS, Lee NG. A Study on Physiological Activity and Antioxidative Activity of Measangi(Capsosiphon fulvescens) Extract. J Environmental Sci. 2010;19(4):407-14.
  9. Jeong YJ, Lee C. Jasan Eobo. 1st ed. Paju:West coast P. 2016:167-90.
  10. Heo J. Donguibogam. 1st ed. Seoul: Bubinbooks. 2007:1947-8.
  11. Yang GS, Oh JW, Lee HE, Lee BH, Lim KM, Lee JY. Topical Application of Dieckol Ameliorates Atopic Dermatitis in NC/Nga Mice by Suppressing Thymic Stromal Lymphopoietin Production. J Investigative Dermatol. 2016;136(5):1062-6. https://doi.org/10.1016/j.jid.2015.12.046
  12. Li Y, Lee SH, Le QT, Kim MM, Kim SK. Anti-allergy effects of phlorotannins on histamine release via binding inhibition between IgE and $Fc{\varepsilon}RI$. J Agric Food Chem. 2008;56:12073-80. https://doi.org/10.1021/jf802732n
  13. Shim SY, Choi JS, Byun DS. Inhibitory effects of phloroglucinol derivarives isolated from Ecklonia stolonifera on $Fc{\varepsilon}RI$ expression. Bioorg Med Chem. 2009;17(13):4734-9. https://doi.org/10.1016/j.bmc.2009.04.050
  14. Eun JY. Anti-inflammatory effect of ethanolic extract from Myagropsis myagroides on murine macrophages and mouse ear edema. MD Dissertation. Pukyong National University. 2013.
  15. Lee CJ. Inhibitory Effects of Sargassum horneri Extracts on Atopic Disease. MD Dissertation. Pukyong National University. 2010.
  16. Turner S, Carder M, Van MT, McNamee R, Lines S, Hussey L, et al. The Incidence of Occupational Skin Disease as Reported to The Health and Occupation Reporting(THOR) Network between 2002 and 2005. Br J Dermatol. 2007;157(4):713-22. https://doi.org/10.1111/j.1365-2133.2007.08045.x
  17. Thyssen JP, Linneberg A, Menne T, Johansen JD. The Epidemiology of Contact Allergy in the General Population: Prevalence and Main Findings. Contact Dermatitis. 2007;57(5): 287-99. https://doi.org/10.1111/j.1600-0536.2007.01220.x
  18. Kim YB. Text of Traditional Korean Dermatology & Surgery. 1st ed. Busan:Sun Woo. 2007:352-3.
  19. Yang HJ, Kim MJ, Kang S, Moon NR, Kim DS, Lee NR, et al. Topical treatments of Saussurea costus root and Thuja orientalis L. synergistically alleviate atopic dermatitislike skin lesions by inhibiting proteaseactivated receptor2 and $NF{\kappa}B$ signaling in HaCaT cells and Nc/Nga mice. J Ethnopharmacol. 2017;199:97-105. https://doi.org/10.1016/j.jep.2017.01.055
  20. Drake LA, Fallon JD, Sober A. Relief of pruritus in patients with atopic dermatitis after treatment with topical doxepin cream. J Amer Acad Dermatol. 1994;31(4):613-6. https://doi.org/10.1016/S0190-9622(94)70225-X
  21. Bonnel RA, La Grenade L, Karwoski CB, Beitz JG. Allergic contact dermatitis from topical doxepin: Food and Drug Administration' s postmarketing surveillance experience. J Amer Acad Dermatol. 2003;48(2):294-6. https://doi.org/10.1067/mjd.2003.46
  22. Tupker RA, De Monchy JGR, Coenraads PJ, Homan A, Van Der Meer JB. Induction of atopic dermatitis by inhalation of house dust mite. J Allergy Clin Immunol. 1996;97:1064-70. https://doi.org/10.1016/S0091-6749(96)70259-2
  23. Nambu M, Shintaku N, Ohta S. Relationship between cord blood level of IgE specific for Dermatophagoides pteronyssinus and allergic manifestations in infancy. Biol Neonate. 2003;83:102-6. https://doi.org/10.1159/000067961
  24. Kutok JL, Pinkus GS, Dorfman DM, Fletcher CDM. Inflammatory pseudotumor of lymph node and spleen: an entity biologically distinct from inflammatory myofibroblastic tumor. Hum Pathol. 2001;32(12):1382-7. https://doi.org/10.1053/hupa.2001.29679
  25. Ahn KM. Role of Mast Cells in Allergic Inflammation and Innate Immunity. Kor J Pediatrics. 2004;47(11);1137-41.
  26. Toru H, Pawankar R, Ra C, Yata J, Nakahata T. Human mast cells produce IL-13 by high-affinity IgE receptor cross-linking : enhanced IL-13 production by IL-4-primed human mast cells. J Allergy Clin Immunol 1998;102:491-502. https://doi.org/10.1016/S0091-6749(98)70140-X
  27. Akira S, Taga T, Kishimoto T. Interleukin6 in biology and medicine. Adv Immunol. 1993;54:1-78.
  28. Kishimoto T. The biology of interleukin6. Blood. 1980;74:1-10.
  29. Urashima M, Chauhan D, Hatziyanni M, Ogata A, Hollenbaugh D, Aruffo A, et al. CD40 ligand triggers interleukin6 mediated B cell differentiation. Leuk. Res. 1996;20:507-15. https://doi.org/10.1016/0145-2126(95)00098-4
  30. Vestergarrd C, Yoneyama H, Murai M, Nakamura K, Tamaki K, Terashima Y, et al. Overproduction of Th2specific chemokines in NC/Nga mice exhibiting atopic dermatitislike lesions. J Clin Invest. 1999;104:1097-105. https://doi.org/10.1172/JCI7613