The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology (한방안이비인후피부과학회지)

The Society of Korean Medicine Ophthalmology, Otolaryngology & Dermatology (대한한방안이비인후피부과학회)
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Effects of Capsosiphon Fulvescens Extract on Contact Dermatitis in NC/Nga Mice

매생이(莓山苔) 추출물이 NC/Nga 마우스의 접촉성 피부염에 미치는 효과

  • Eom, Ye-Jin (Dept. of Korean Medicine Ophthalmology & Otolaryngology & Dermatology, College of Korean Medicine, Sangji University) ;
  • Hong, Chul-Hee (Dept. of Korean Medicine Ophthalmology & Otolaryngology & Dermatology, College of Korean Medicine, Sangji University)
  • 엄예진 (상지대학교 한의과대학 한방안이비인후피부과학교실) ;
  • 홍철희 (상지대학교 한의과대학 한방안이비인후피부과학교실)
  • Received : 2017.09.28
  • Accepted : 2017.11.13
  • Published : 2017.11.25
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Abstract

Objectives : The aim of this study is to report the effect of Capsosiphon fulvescens(Maesangi) extract(MSE) on contact dermatitis(CD). Methods : CD induced by Dermatophagoides farinae body(Dfb) in NC/Nga mice. 4% sodium dodecyl sulfate(SDS) $150{\mu}l$ and Dfb(10mg/ml) ointment 100mg were topically treated twice a week for four weeks. MSE 200 mg/kg was topically treated every 4weeks. Every week, we examined the skin lesions, weight of spleen and lymph node, epidermal thickness, production of Tumor necrosis factor-alpha($TNF-{\alpha}$) and interleukin-6(IL-6). Results : MSE reduced features of Dfb-induced skin lesions, weight of spleen and production of $TNF-{\alpha}$. MSE significantly reduced weight of lymph node, epidermal thickness, number of mast cells and production of IL-6. Conclusions : MSE may have a potential therapeutic effects for CD by suppressing allergic inflammation.

Keywords

References

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