The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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The Effect of Angelica gigas Nakai Extract and Bacillus Polyfermenticus KJS-2 on Atopic Dermatitis induced by DNCB in mice

DNCB로 유도된 아토피 피부염에 대한 당귀 추출물과 Bacillus polyfermenticus KJS-2의 효과

  • Ryu, Deok-Hyun (Dept. of Oriental Medical Ophthalmology & Otolaryngology & Dermatology, College of Oriental Medicine, Dae-jeon University) ;
  • Oh, Sa-Rang (Wellbeingtainment Co., Ltd.) ;
  • Jung, Tae-Sung (Wellbeingtainment Co., Ltd.) ;
  • Ryu, Deok-Seon (Dept. of Biomedical Laboratory Science, Soonchunhyang University)
  • 류덕현 (대전대학교 한의과대학 안이비인후피부과) ;
  • 오사랑 ((주)웰빙테인먼트) ;
  • 정태성 ((주)웰빙테인먼트) ;
  • 류덕선 (순천향대학교 의료과학대학 임상병리학과)
  • Received : 2017.07.18
  • Accepted : 2017.08.09
  • Published : 2017.09.30
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Abstract

Objectives: The purpose of this study was to investigate the effects of Angelica gigas Nakai extract(AGNE) and Bacillus polyfermenticus KJS-2 (BP2) on atopic dermatitis (AD) induced by 2, 4-dinitrochlorobenzene (DNCB) in mice. Methods: In the experiment, we divided mice into four groups: a control group, a DNCB group, an AGNE group, and an AGNE+BP2 group. Then we examined the changes in scratching frequency, clinical aspects on dorsum skin, immunoglobulin (IgE), cytokines ($TNF-{\alpha}$, IL-6) and expression of COX-2. Resutls: From the experiment, the scratching frequency was significantly dropped in AGNE group and AGNE+BP2 group. Clinical observations of dorsum skin, there were a severe keratotic lesion and drop of dead skin cell in DNCB group, but symptoms of AD were decreased 39.6% in AGNE group and 49.6% in AGNE+BP2 group during 3 weeks. IgE, $TNF-{\alpha}$ and IL-6 were decreased significantly in both AGNE and AGNE+BP2 group. Expression of COX-2 was also decreased significantly in both groups. Conclusions: In conclusion, these data suggest that AGNE can decrease symptoms of AD and BP2 makes AGNE more effective. So AGNE can be useful herbal therapy for AD.

Keywords

References

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