Korean journal of dermatology (대한피부과학회지)

Korean Dermatological Association (대한피부과학회)
권호 표지

Deep Benign Fibrous Histiocytoma Showing Multiple Metastases

다발성 전이를 동반한 심부 양성 섬유조직구종

  • Sim, Hyun Bo (Department of Dermatology, Kyungpook National University School of Medicine) ;
  • Kim, Min Ji (Department of Dermatology, Kyungpook National University School of Medicine) ;
  • Chae, Soo Yuhl (Department of Dermatology, Kyungpook National University School of Medicine) ;
  • Lee, Weon Ju (Department of Dermatology, Kyungpook National University School of Medicine) ;
  • Lee, Seok-Jong (Department of Dermatology, Kyungpook National University School of Medicine) ;
  • Kim, Do Won (Department of Dermatology, Kyungpook National University School of Medicine) ;
  • Jang, Yong Hyun (Department of Dermatology, Kyungpook National University School of Medicine)
  • 심현보 (경북대학교 의학전문대학원 피부과학교실) ;
  • 김민지 (경북대학교 의학전문대학원 피부과학교실) ;
  • 채수열 (경북대학교 의학전문대학원 피부과학교실) ;
  • 이원주 (경북대학교 의학전문대학원 피부과학교실) ;
  • 이석종 (경북대학교 의학전문대학원 피부과학교실) ;
  • 김도원 (경북대학교 의학전문대학원 피부과학교실) ;
  • 장용현 (경북대학교 의학전문대학원 피부과학교실)
  • Received : 2015.10.28
  • Accepted : 2016.05.03
  • Published : 2017.06.30

⟨ Previous Next ⟩

Abstract

Some morphological variants of benign fibrous histiocytoma (dermatofibroma) present with distinct clinical features. In particular, atypical, aneurysmal, and cellular fibrous histiocytoma are associated with a significant risk of local recurrence. Furthermore, very rarely, cutaneous fibrous histiocytoma can lead to metastatic disease. Deep benign fibrous histiocytoma is an uncommon and poorly recognized clinical subtype that arises in subcutaneous or deep soft tissue. Deep benign fibrous histiocytoma has many histologic features in common with cellular fibrous histiocytoma. Deep benign fibrous histiocytoma recurs in approximately 20% of cases and may rarely metastasize. We report a rare case of deep benign fibrous histiocytoma with metastatic potential in a 38-year-old man who presented with a 2-year history of a recurrent hard mass on his left shoulder.

Keywords

References

  1. Gleason BC, Fletcher CD. Deep “benign” fibrous histiocytoma: clinicopathologic analysis of 69 cases of a rare tumor indicating occasional metastatic potential. Am J Surg Pathol 2008;32:354-362 https://doi.org/10.1097/PAS.0b013e31813c6b85
  2. Park JW, Chung JM, Jung KE, Park BC, Kim MH, Cinn YW. A Case of Subcutaneous Benign Fibrous Histiocytoma. Korean J Dermatol 2009;47:565-569
  3. Doyle LA, Fletcher CD. Metastasizing “benign” cutaneous fibrous histiocytoma: a clinicopathologic analysis of 16 cases. Am J Surg Pathol 2013;37:484-495 https://doi.org/10.1097/PAS.0b013e31827070d4
  4. Chung J, Namkoong S, Sim JH, Lee JS, Hong SP, Kim MH, et al. Deep penetrating benign fibrous histiocytoma of the foot associated with throbbing pain. Ann Dermatol 2011;23:S239-242 https://doi.org/10.5021/ad.2011.23.S2.S239
  5. Hannachi Sassi S, Trabelsi M, Abid L, Mrad K, Abbess I, Dhouib R, et al. [Deep benign fibrous histiocytoma: a case report]. Rev Chir Orthop Reparatrice Appar Mot 2006;92:809-812 https://doi.org/10.1016/S0035-1040(06)75950-5
  6. Fletcher CD. Benign fibrous histiocytoma of subcutaneous and deep soft tissue: a clinicopathologic analysis of 21 cases. Am J Surg Pathol 1990;14:801-809 https://doi.org/10.1097/00000478-199009000-00001
  7. Gu M, Sohn K, Kim D, Kim B. Metastasizing dermatofibroma in lung. Ann Diagn Pathol 2007;11:64-67 https://doi.org/10.1016/j.anndiagpath.2005.12.001
  8. Guillou L, Gebhard S, Salmeron M, Coindre JM. Metastasizing fibrous histiocytoma of the skin: a clinicopathologic and immunohistochemical analysis of three cases. Mod Pathol 2000;13:654-660 https://doi.org/10.1038/modpathol.3880115
  9. Hui P, Glusac EJ, Sinard JH, Perkins AS. Clonal analysis of cutaneous fibrous histiocytoma (dermatofibroma). J Cutan Pathol 2002;29:385-389 https://doi.org/10.1034/j.1600-0560.2002.290701.x
  10. Walther C, Hofvander J, Nilsson J, Magnusson L, Domanski HA, Gisselsson D, et al. Gene fusion detection in formalinfixed paraffin-embedded benign fibrous histiocytomas using fluorescence in situ hybridization and RNA sequencing. Lab Invest 2015;95:1071-1076 https://doi.org/10.1038/labinvest.2015.83
  11. Jedrych J, Nikiforova M, Kennedy TF, Ho J. Epithelioid cell histiocytoma of the skin with clonal ALK gene rearrangement resulting in VCL-ALK and SQSTM1-ALK gene fusions. Br J Dermatol 2015;172:1427-1429 https://doi.org/10.1111/bjd.13548
  12. Szablewski V, Laurent-Roussel S, Rethers L, Rommel A, Van Eeckhout P, Camboni A, et al. Atypical fibrous histiocytoma of the skin with CD30 and p80/ALK1 positivity and ALK gene rearrangement. J Cutan Pathol 2014;41:715-719 https://doi.org/10.1111/cup.12352
  13. Diaz-Cascajo C, Weyers W, Rey-Lopez A, Borghi S. Deep dermatofibrosarcoma protuberans: a subcutaneous variant. Histopathology 1998;32:552-555 https://doi.org/10.1046/j.1365-2559.1998.00343.x
  14. Mckenna DB, Kavanagh GM, Mclaren KM, Tidman MJ. Aneurysmal fibrous histiocytoma: an unusual variant of cutaneous fibrous histiocytoma. J Eur Acad Dermatol Venereol 1999;12:238-240 https://doi.org/10.1111/j.1468-3083.1999.tb01035.x