Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지
DOI QR코드

DOI QR Code

Effect of Albizziae Cortex Water Extract on Cognition and Memory Impairments

합환피의 인지 및 기억력 개선 효과에 대한 연구

  • Kee, Ji Ye (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang-Oriental Medicines Research Institute, Wonkwang University) ;
  • Hong, Seung Heon (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang-Oriental Medicines Research Institute, Wonkwang University) ;
  • Park, Jin Han (Division of Bio-technology and Convergence, Daegu Haany University)
  • 기지예 (원광대학교 한약학과) ;
  • 홍승헌 (원광대학교 한약학과) ;
  • 박진한 (대구한의대학교 바이오산업융합학부)
  • Received : 2017.07.05
  • Accepted : 2017.10.25
  • Published : 2017.10.25
Download PDF
⟨ Previous Next ⟩

Abstract

The aim of this study was to investigate the effects of the water extract of Albizziae Cortex (AC) on the learning and memory impairments. AC was administered to normal mouse and scopolamine-injected amnesia mouse model. Passive avoidance test, Y-maze test, and Morris water maze test were conducted to confirm the cognitive-enhancing activities of AC. Acetylcholinesterase (AChE) activity and acetylcholine (Ach) content were measured after oral administration of AC. On the passive avoidance test, AC (200 mg/kg) significantly increased latency time and recovered scopolamine-impaired learning and memory in mice. In addition, AC (200 mg/kg) reduced Exploration time in target quadrant and reversed the scopolamine-induced cognitive impairments in the Y-maze test. Moreover, AC (200 mg/kg) increased exploration time in target quadrant and improved scopolamine-reduced escape latencies in the Morris water maze test. These effects were presented by regulatory effects of AC on AChE activity and Ach content. Taken together, AC increases cognitive-enhancing activities and ameliorates scopolamine-induced learning and memory impairment. AC might be a potential agent for prevention and treatment of amnesia and dementia.

Keywords

References

  1. Oh SG. Neurotransmitters and brain disease. Shinilbooks. 2005:345-64.
  2. Evans DA, Funkenstein HH, Albert MS, Scherr PA, Cook NR, Chown MJ, Hebert LE, Hennekens CH, Taylor JO. Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported. JAMA. 1989;262:2551-6. https://doi.org/10.1001/jama.1989.03430180093036
  3. Nordberg A. Pharmacological treatment of cognitive dysfunction in dementia disorders. Acta Neurologica Scandinavica. 1996;168:87-92.
  4. Lemiere JJ. Van D, Dorn R. Treatment of Alzheimer's disease: an evaluation of cholinergic approach. Acta Neurol. Belg. 1999;99:96-106.
  5. Kuhl DE, Koeppe RA, Minoshima S, Snyder SE, Ficaro EP, Foster NL, Frey KA, Kilbourn MR. In vivo mapping of cerebral acetylcholinesterase activity in aging and Alzheimer' disease. Neurology. 1999;52:691-9. https://doi.org/10.1212/WNL.52.4.691
  6. Dawson GR, Iversen SD. The effects of novel cholinesterase inhibitors and selective muscarinic receptor agonists in tests of reference and working memory. Behavioural Brain Research. 199. 57:143-53.
  7. Summers WK, Tachiki KH, Kling A. Tacrine in the treatment of Alzheimer's disease. A clinical update and recent pharmacologic studies. Eur Neurol. 1989;29:28-32. https://doi.org/10.1159/000116478
  8. Kim JM, Kim DH, Park SJ, Jung JW, Ryu JH. Memory Enhancing Properties of the Ethanolic Extract of Black Sesame and its Ameliorating Properties on Memory Impairments in Mice. Kor. J. Pharmacogn. 2010;41(3):196-203
  9. Howes MJ, Perry NS, Houghton PJ. Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders. Phytother. Res. 2003;7:1-18
  10. Yao NL. Zhong Yi Zheng Zhuang Jian Bie Zhen Duan Xue, Ren Min Wei Sheng Chu Ban She. 2000:106-7.
  11. Oriental pharmacology textbook compilation committee. Oriental pharmacology. Shinilbooks. 2005:29-41.
  12. Shin MK. Clinical Traditional Herbalogy. Yonunglimsa. 2002:647-8
  13. Lee SH, Lee YR, Ryu DG, Kim HR, Kim MS, Kim BS, Kwon KB. Inhibitory Effects of Albizziae Cortex Extracts on Adipocyte Differentiation. Journal of Physiology & Pathology in Korean Medicine. 2016;30:447-51. https://doi.org/10.15188/kjopp.2016.12.30.6.447
  14. Park YJ, Jung WC, Jeong DY, Lee YU, Lee I, Lee KS, Jeon BH, Sung KK, Moon BS. Effects of the Water Extract from Albizzia julibrissin on Apoptosis and Cell Cycle Progression in the Human Leukemic Jurkat Cells. Journal of Physiology & Pathology in Korean Medicine. 2003;17:1383-92.
  15. Lee SW, Kang BS. Inhibition Effects of Albizzia julibrissin water extract on Lipid peroxidation in Benzo(a)pyrene - Treated Mice. Journal of the institute oriental medicine. 2001;3:107-16.
  16. LeDoux JE. Emotional memory system in the brain. Behav Brain Res. 1993;20;58(1-2):69-79. https://doi.org/10.1016/0166-4328(93)90091-4
  17. LeDoux JE. Emotional memory: in search of systems and synapses. Ann N Y Acad Sci. 1993;702:149-57 https://doi.org/10.1111/j.1749-6632.1993.tb17246.x
  18. Morris R. Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods. 1984;11(1):47-60. https://doi.org/10.1016/0165-0270(84)90007-4
  19. Sarter M, Bodewitz G, Stephens DN. Attenuation of scopolamine-induced impairment of spontaneous alternation behavior by antagonist but not inverse agonist and beta-carboline. Psycopharmacology. 1998;94(4):491-5.
  20. Vincent D, Segonzac G, Vincent MC. Colorimetric determination of acetylcholine by the Hestrin hydroxylamine reaction and its application in pharmacy. Ann Pharm Fr. 1958;16:179-185.
  21. Ellman GL, Courtney KD, Andres V Jr, Feather-Stone RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol. 1961;7:88-95. https://doi.org/10.1016/0006-2952(61)90145-9
  22. Bae HS, Shim IS. Establishment of functionality evaluation system for learning and memory of health functional food. 2003:664-54.
  23. Tanabe F, Miyasaka N, Kubota T, Aso T. Estrogen and progesterone improve scopolamine-induced impairment of spatial memory. Journal of Medical and Dental Sciences. 2004;51:89-98.
  24. Gong DY, Choi YS. Development of New Analytical Method Evaluating Working Memory on Y Maze. 2016;26:234-40. https://doi.org/10.5352/JLS.2016.26.2.234
  25. Blokland A. Acetylcholine: a neurotransmitter for learning and memory? Barin Res. Rev. 1995;21:285-300 https://doi.org/10.1016/0165-0173(95)00016-X
  26. Davies P, Maloney AJ. Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet. 1976;8000:1403.