The Journal of the Korea Contents Association (한국콘텐츠학회논문지)

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Association between the Polymorphism of Glutathione S-transferase Genes and Chronic Myeloid Leukemia in Asian Population: a Meta-analysis

아시아인종에서 만성골수성백혈병과 Glutathione S-transferase 유전자 다형성의 메타분석

  • 김희성 (단국대학교 의과대학 제일병원 진단검사의학과)
  • Received : 2017.09.04
  • Accepted : 2017.09.27
  • Published : 2017.10.28
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Abstract

To verify the association between susceptibility to chronic myeloid leukemia (CML) and GSTM1, GSTT1 gene polymorphisms in Asian populations, 9 papers published until July 2017 were cited in a meta-analysis. The null present types of the GSTM1, GSTT1 gene were analyzed individually. The significant association was found between CML and GST polymorphism (GSTM1; OR=1.306, 95% CI=1.091-1.563, p=0.004, GSTT1; OR=1.987, 95% CI=1.438-2.746, p=0.000). In addition, there was association between CML and the null type of the combination GSTM1-GSTT1 polymorphisms (OR=4.191, 95% CI=2.833-6.201, p=0.000). Thus, genetic polymorphisms of the GSTM1, GSTT1 and combination GSTM1-GSTT1 polymorphism in Asian populations may be risk factors for CML.

아시아인종에서 만성골수성백혈병 (Chronic myeloid leukemia; CML)과 Glutathione S-transferase(GST) 유전자 다형성과 관련된 감수성을 검증하기 위해, 2017년 7월까지 발표된 9편의 논문들을 메타분석에 인용하였다. GST 유전자 다형성의 아형 중 M1 (GSTM1)과 T1 (GSTT1)의 유전자의 null, present 유형을 개별적으로 분석하였다. CML환자와 GST 유전자 다형성 사이에 연관성이 발견되었다.(GSTM1; OR=1.306, 95% CI=1.091-1.563, p=0.004, GSTT1; OR=1.987, 95% CI=1.438-2.746, p=0.000). 또한, CML 환자와 GSTM1-GSTT1 유전자 다형성 조합 null 유형의 연관성이 있었다(OR=4.191, 95% CI=2.833-6.201, p=0.000). 이와 같이, 아시아인종에서 GSTM1 유전자 다형성, GSTT1 유전자 다형성, GSTM1-GSTT1 유전자 다형성 조합은 CML 환자의 위험인자가 될 수 있다.

Keywords

References

  1. E. Estey and H. Dohner, "Acute myeloid leukaemia," Lancet, Vol.368, No.9550, pp.1894-1907, 2006. https://doi.org/10.1016/S0140-6736(06)69780-8
  2. J. D. Hayes, J. U. Flanagan, and I. R. Jowsey, "Glutathione transferases," Annu Rev Pharmacol Toxicol, Vol.45, pp.51-88, 2005. https://doi.org/10.1146/annurev.pharmtox.45.120403.095857
  3. A. Hatagima, "Genetic polymorphisms and metabolism of endocrine disruptors in cancer susceptibility," Cad Saude Publica, Vol.18, No.2, pp.357-377, 2002. https://doi.org/10.1590/S0102-311X2002000200002
  4. D. A. Arber, A. Orazi, R. Hasserjian, J. Thiele, M. J. Borowitz, M. M. Le Beau, C. D. Bloomfield, M. Cazzola, and J. W. Vardiman, "The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia," Blood, Vol.127, No.20, pp.2391-2405, 2016. https://doi.org/10.1182/blood-2016-03-643544
  5. E. Jabbour and H. Kantarjian, "Chronic myeloid leukemia: 2014 update on diagnosis, monitoring, and management," Am J Hematol, Vol.89, No.5, pp.547-556, 2014. https://doi.org/10.1002/ajh.23691
  6. S. O'Brien, J. P. Radich, C. N. Abboud, M. Akhtari, J. K. Altman, E. Berman, P. Curtin, D. J. DeAngelo, M. Deininger, S. Devine, A. T. Fathi, J. Gotlib, M. Jagasia, P. Kropf, J. O. Moore, A. Pallera, V. V. Reddy, N. P. Shah, B. D. Smith, D. S. Snyder, M. Wetzler, K. Gregory, and H. Sundar, "Chronic myelogenous leukemia, version 1.2015," J Natl Compr Canc Netw, Vol.12, No.11, pp.1590-1610, 2014. https://doi.org/10.6004/jnccn.2014.0159
  7. M. W. Deininger, J. M. Goldman, and J. V. Melo, "The molecular biology of chronic myeloid leukemia," Blood, Vol.96, No.10, pp.3343-3356, 2000.
  8. J. Bjork, M. Albin, H. Welinder, H. Tinnerberg, N. Mauritzson, T. Kauppinen, U. Stromberg, B. Johansson, R. Billstrom, Z. Mikoczy, T. Ahlgren, P. G. Nilsson, F. Mitelman, and L. Hagmar, "Are occupational, hobby, or lifestyle exposures associated with Philadelphia chromosome positive chronic myeloid leukaemia?," Occup Environ Med, Vol.58, No.11, pp.722-727, 2001. https://doi.org/10.1136/oem.58.11.722
  9. P. D. Josephy, "Genetic variations in human glutathione transferase enzymes: significance for pharmacology and toxicology," Human genomics and proteomics : HGP, Vol.2010, p.876940, 2010.
  10. P. J. Jakobsson, S. Thoren, R. Morgenstern and B. Samuelsson, "Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target," Proceedings of the National Academy of Sciences of the United States of America, Vol.96, pp.7220-7225, 1999. https://doi.org/10.1073/pnas.96.13.7220
  11. D. M. Townsend, K. D. Tew, and H. Tapiero, "The importance of glutathione in human disease," Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, Vol.57, pp.145-155, 2003. https://doi.org/10.1016/S0753-3322(03)00043-X
  12. P. Jemth, G. Stenberg, G. Chaga and B. Mannervik, "Heterologous expression, purification and characterization of rat class theta glutathione transferase T2-2," The Biochemical journal, Vol.316(Pt 1), pp.131-136, 1996. https://doi.org/10.1042/bj3160131
  13. A. M. Ghelani, A. Samanta, A. C. Jones, and S. S. Mastana, "Association analysis of TNFR2, VDR, A2M, GSTT1, GSTM1, and ACE genes with rheumatoid arthritis in South Asians and Caucasians of East Midlands in the United Kingdom," Rheumatology international, Vol.31, pp.1355-1361, 2011. https://doi.org/10.1007/s00296-010-1478-2
  14. B. T. Ashok and R. Ali, "Binding of human anti-DNA autoantibodies to reactive oxygen species modified-DNA and probing oxidative DNA damage in cancer using monoclonal antibody," International journal of cancer. Journal international du cancer, Vol.78, pp.404-409, 1998. https://doi.org/10.1002/(SICI)1097-0215(19981109)78:4<404::AID-IJC2>3.0.CO;2-Y
  15. B. T. Ashok and R. Ali, "The aging paradox: free radical theory of aging," Experimental gerontology, Vol.34, pp.293-303, 1999. https://doi.org/10.1016/S0531-5565(99)00005-4
  16. B. Ardesjo, C. M. Hansson, C. E. Bruder, F. Rorsman, C. Betterle, J. P. Dumanski, O. Kampe, and O. Ekwall, "Autoantibodies to glutathione S-transferase theta 1 in patients with primary sclerosing cholangitis and other autoimmune diseases," Journal of Autoimmunity, Vol.30, pp.273-282, 2008. https://doi.org/10.1016/j.jaut.2007.11.008
  17. C. Duggan, R. Ballard-Barbash, R. N. Baumgartner, K. B. Baumgartner, L. Bernstein, and A. McTiernan, "Associations between null mutations in GSTT1 and GSTM1, the GSTP1 Ile(105)Val polymorphism, and mortality in breast cancer survivors," Springerplus, Vol.2, p.450, 2013. https://doi.org/10.1186/2193-1801-2-450
  18. W. Tan, N. Song, G. Q. Wang, Q. Liu, H. J. Tang, F. F. Kadlubar, and D. X. Lin, "Impact of genetic polymorphisms in cytochrome P450 2E1 and glutathione S-transferases M1, T1, and P1 on susceptibility to esophageal cancer among high-risk individuals in China," Cancer Epidemiol Biomarkers Prev, Vol.9, No.6, pp.551-556, 2000.
  19. H. R. He, X. X. Zhang, J. Y. Sun, S. S. Hu, Y. Ma, Y. L. Dong, and J. Lu, "Glutathione S-transferase gene polymorphisms and susceptibility to chronic myeloid leukemia," Tumour Biol, Vol.35, No.6, pp.6119-6125, 2014. https://doi.org/10.1007/s13277-014-1810-7
  20. M. Karkucak, T. Yakut, T. Gulten, and R. Ali, "Investigation of GSTP1 (Ile105V al) Gene Polymorphism in Chronic Myeloid Leukaemia Patients," Int J Hum Genet, Vol.12, No.3, pp.145-149, 2012. https://doi.org/10.1080/09723757.2012.11886176
  21. A. Hishida, S. Terakura, N. Emi, K. Yamamoto, M. Murata, K. Nishio, Y. Sekido, T. Niwa, N. Hamajima, and T. Naoe, "GSTT1 and GSTM1 deletions, NQO1 C609T polymorphism and risk of chronic myelogenous leukemia in Japanese," Asian Pac J Cancer Prev, Vol.6, No.3, pp.251-255, 2005.
  22. B. C. Mondal, N. Paria, S. Majumdar, S. Chandra, A. Mukhopadhyay, U. Chaudhuri, and U. B. Dasgupta, "Glutathione S-transferase M1 and T1 null genotype frequency in chronic myeloid leukaemia," Eur J Cancer Prev, Vol.14, No.3, pp.281-284, 2005. https://doi.org/10.1097/00008469-200506000-00014
  23. A. Hirvonen, "Polymorphisms of xenobiotic-metabolizing enzymes and susceptibility to cancer," Environ Health Perspect, Vol.107, Suppl.1, pp.37-47, 1999. https://doi.org/10.1289/ehp.99107s137
  24. P. Bajpai, A. K. Tripathi, and D. Agrawal, "Increased frequencies of glutathione-S-transferase (GSTM1 and GSTT1) null genotypes in Indian patients with chronic myeloid leukemia," Leuk Res, Vol.31, No.10, pp.1359-1363, 2007. https://doi.org/10.1016/j.leukres.2007.02.003
  25. E. Zintzaras and J. Lau, "Trends in meta-analysis of genetic association studies," J Hum Genet, Vol.53, No.1, pp.1-9, 2008. https://doi.org/10.1007/s10038-007-0223-5
  26. E. Zintzaras, "C677T and A1298C methylenetetrahydrofolate reductase gene polymorphisms in schizophrenia, bipolar disorder and depression: a meta-analysis of genetic association studies," Psychiatr Genet, Vol.16, No.3, pp.105-115, 2006. https://doi.org/10.1097/01.ypg.0000199444.77291.e2
  27. H. C. Chen, W. X. Hu, Q. X. Liu, W. K. Li, F. Z. Chen, Z. Z. Rao, X. F. Liu, Y. P. Luo, and Y. F. Cao, "Genetic polymorphisms of metabolic enzymes CYP1A1, CYP2D6, GSTM1 and GSTT1 and leukemia susceptibility," Eur J Cancer Prev, Vol.17, No.3, pp.251-258, 2008. https://doi.org/10.1097/CEJ.0b013e3282b72093
  28. M. Taspinar, S. E. Aydos, O. Comez, A. H. Elhan, H. G. Karabulut, and A. Sunguroglu, "CYP1A1, GST gene polymorphisms and risk of chronic myeloid leukemia," Swiss Med Wkly, Vol.138, No.1-2, pp.12-17, 2008.
  29. G. Bhat, A. Bhat, A. Wani, N. Sadiq, S. Jeelani, R. Kaur, A. Masood, and B. Ganai, "Polymorphic variation in glutathione-S-transferase genes and risk of chronic myeloid leukaemia in the Kashmiri population," Asian Pac J Cancer Prev, Vol.13, No.1, pp.69-73, 2012. https://doi.org/10.7314/APJCP.2012.13.1.069
  30. N. Ozten, A. Sunguroglu, and M. C. Bosland, "Variations in glutathione-S-transferase genes influence risk of chronic myeloid leukemia," Hematol Oncol, Vol.30, No.3, pp.150-155, 2012. https://doi.org/10.1002/hon.1018
  31. W. Al-Achkar, G. Azeiz, F. Moassass, and A. Wafa, "Influence of CYP1A1, GST polymorphisms and susceptibility risk of chronic myeloid leukemia in Syrian population," Med Oncol, Vol.31, No.5, p.889, 2014. https://doi.org/10.1007/s12032-014-0889-4
  32. W. Al-Achkar, F. Moassass, R. Aroutiounian, T. Harutyunyan, T. Liehr, and A. Wafa, "Effect of Glutathione S-transferase mu 1 (GSTM1) gene polymorphism on chronic myeloid leukemia risk and Imatinib treatment response," Meta gene, Vol.12, pp.113-117, 2017. https://doi.org/10.1016/j.mgene.2017.02.006
  33. K. Sailaja, D. Surekha, D. N. Rao, D. R. Rao, and S. Vishnupriya, "Association of the GSTP1 gene (Ile105Val) polymorphism with chronic myeloid leukemia," Asian Pac J Cancer Prev, Vol.11, No.2, pp.461-464, 2010.
  34. T. R. Rebbeck, "Molecular epidemiology of the human glutathione S-transferase genotypes GSTM1 and GSTT1 in cancer susceptibility," Cancer Epidemiol Biomarkers Prev, Vol.6, No.9, pp.733-743, 1997.
  35. S. C. Cotton, L. Sharp, J. Little, and N. Brockton, "Glutathione S-transferase polymorphisms and colorectal cancer: a HuGE review," Am J Epidemiol, Vol.151, No.1, pp.7-32, 2000. https://doi.org/10.1093/oxfordjournals.aje.a010124
  36. C. de Oliveira Hiragi, A. L. Miranda-Vilela, D. M. Rocha, S. F. de Oliveira, A. Hatagima, and M. de Nazare Klautau-Guimaraes, "Superoxide dismutase, catalase, glutathione peroxidase and gluthatione S-transferases M1 and T1 gene polymorphisms in three Brazilian population groups," Genet Mol Biol, Vol.34, No.1, pp.11-18, 2011. https://doi.org/10.1590/S1415-47572010005000102
  37. M. E. Maciel, F. K. Oliveira, G. B. Propst, M. da Graca Bicalho, I. J. Cavalli, and E. M. Ribeiro, "Population analysis of xenobiotic metabolizing genes in South Brazilian Euro and Afro-descendants," Genet Mol Biol, Vol.32, No.4, pp.723-728, 2009. https://doi.org/10.1590/S1415-47572009005000087
  38. E. Zintzaras, "Glutathione S-transferase M1 and T1 genes and susceptibility to chronic myeloid leukemia: a meta-analysis," Genet Test Mol Biomarkers, Vol.13, No.6, pp.791-797, 2009. https://doi.org/10.1089/gtmb.2009.0079
  39. S. Landi, "Mammalian class theta GST and differential susceptibility to carcinogens: a review," Mutat Res, Vol.463, No.3, pp.247-283, 2000. https://doi.org/10.1016/S1383-5742(00)00050-8
  40. M. A. Mehlman, "Causal relationship from exposure to chemicals in oil refining and chemical industries and malignant melanoma," Ann N Y Acad Sci, Vol.1076, pp.822-828, 2006. https://doi.org/10.1196/annals.1371.005
  41. A. Khalade, M. S. Jaakkola, E. Pukkala, and J. J. Jaakkola, "Exposure to benzene at work and the risk of leukemia: a systematic review and meta-analysis," Environ Health, Vol.9, p.31, 2010. https://doi.org/10.1186/1476-069X-9-31
  42. E. Zintzaras and J. Lau, "Synthesis of genetic association studies for pertinent gene-disease associations requires appropriate methodological and statistical approaches," J Clin Epidemiol, Vol.61, No.7, pp.634-645, 2008. https://doi.org/10.1016/j.jclinepi.2007.12.011
  43. E. Zintzaras and J. P. Ioannidis, "Meta-analysis for ranked discovery datasets: theoretical framework and empirical demonstration for microarrays," Comput Biol Chem, Vol.32, No.1, pp.38-46, 2008. https://doi.org/10.1016/j.compbiolchem.2007.09.003
  44. N. Zdoukopoulos and E. Zintzaras, "Genetic risk factors for placental abruption: a HuGE review and meta-analysis," Epidemiology, Vol.19, No.2, pp.309-323, 2008. https://doi.org/10.1097/EDE.0b013e3181635694
  45. H. D. Hosgood, 3rd, S. I. Berndt, and Q. Lan, "GST genotypes and lung cancer susceptibility in Asian populations with indoor air pollution exposures: a meta-analysis," Mutat Res, Vol.636, No.1-3, pp.134-143, 2007. https://doi.org/10.1016/j.mrrev.2007.02.002
  46. E. Zintzaras and G. D. Kitsios, "Synopsis and synthesis of candidate-gene association studies in chronic lymphocytic leukemia: the CUMAGAS-CLL information system," Am J Epidemiol, Vol.170, No.6, pp.671-678, 2009. https://doi.org/10.1093/aje/kwp201
  47. H. Bartsch, U. Nair, A. Risch, M. Rojas, H. Wikman, and K. Alexandrov, "Genetic polymorphism of CYP genes, alone or in combination, as a risk modifier of tobacco-related cancers," Cancer Epidemiol Biomarkers Prev, Vol.9, No.1, pp.3-28, 2000.
  48. P. Das, A. P. Shaik, and V. K. Bammidi, "Meta-analysis study of glutathione-S-transferases (GSTM1, GSTP1, and GSTT1) gene polymorphisms and risk of acute myeloid leukemia," Leuk Lymphoma, Vol.50, No.8, pp.1345-1351, 2009. https://doi.org/10.1080/10428190903003236
  49. E. Zintzaras, "Association of methylenetetrahydrofolate reductase (MTHFR) polymorphisms with genetic susceptibility to gastric cancer: a meta-analysis," J Hum Genet, Vol.51, No.7, pp.618-624, 2006. https://doi.org/10.1007/s10038-006-0405-6
  50. E. Zintzaras, S. Giannouli, P. Rodopoulou, and M. Voulgarelis, "The role of MTHFR gene in multiple myeloma," J Hum Genet, Vol.53, No.6, pp.499-507, 2008. https://doi.org/10.1007/s10038-008-0277-z