Radiation Oncology Journal

The Korean Society for Radiation Oncology (대한방사선종양학회)
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Moderate hypofractionated image-guided thoracic radiotherapy for locally advanced node-positive non-small cell lung cancer patients with very limited lung function: a case report

  • Manapov, Farkhad (Department of Radiation Oncology, Ludwig-Maximilian University of Munich) ;
  • Roengvoraphoj, Olarn (Department of Radiation Oncology, Ludwig-Maximilian University of Munich) ;
  • Li, Minglun (Department of Radiation Oncology, Ludwig-Maximilian University of Munich) ;
  • Eze, Chukwuka (Department of Radiation Oncology, Ludwig-Maximilian University of Munich)
  • Received : 2017.03.16
  • Accepted : 2017.05.29
  • Published : 2017.06.30
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Abstract

Patients with locally advanced lung cancer and very limited pulmonary function (forced expiratory volume in 1 second $[FEV1]{\leq}1L$) have dismal prognosis and undergo palliative treatment or best supportive care. We describe two cases of locally advanced node-positive non-small cell lung cancer (NSCLC) patients with very limited lung function treated with induction chemotherapy and moderate hypofractionated image-guided radiotherapy (Hypo-IGRT). Hypo-IGRT was delivered to a total dose of 45 Gy to the primary tumor and involved lymph nodes. Planning was based on positron emission tomography-computed tomography (PET/CT) and four-dimensional computed tomography (4D-CT). Internal target volume (ITV) was defined as the overlap of gross tumor volume delineated on 10 phases of 4D-CT. ITV to planning target volume margin was 5 mm in all directions. Both patients showed good clinical and radiological response. No relevant toxicity was documented. Hypo-IGRT is feasible treatment option in locally advanced node-positive NSCLC patients with very limited lung function ($FEV1{\leq}1L$).

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References

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