Journal of Korean Medical Science

Korean Acad Medical Sciences (대한의학회)
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Reference Values for the Revised Anti-Müllerian Hormone Generation II Assay: Infertile Population-based Study

  • Lee, Joong Yeup (Hamchoon Women's Clinic) ;
  • Ahn, Soyeon (Medical Research Collaborating Center, Seoul National University Bundang Hospital) ;
  • Lee, Jung Ryeol (Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital) ;
  • Jee, Byung Chul (Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital) ;
  • Kim, Chung Hyon (Hamchoon Women's Clinic) ;
  • Seo, Soyeon (Samkwang Medical Laboratories) ;
  • Suh, Chang Suk (Department of Obstetrics and Gynecology, Seoul National University College of Medicine) ;
  • Kim, Seok Hyun (Department of Obstetrics and Gynecology, Seoul National University College of Medicine)
  • Received : 2016.09.19
  • Accepted : 2017.01.30
  • Published : 2017.05.10
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Abstract

Anti-$M{\ddot{u}}llerian$ hormone (AMH) is now accepted as an important clinical marker of ovarian reserve and is increasingly measured as an initial evaluation at infertility clinics. The aim of this study was to establish reference values for the revised second generation (Gen II) assay using population-based data. In this population-based cohort study, AMH data from unselected infertile women aged 25-45 years from June 2013 to June 2014 (n = 15,801) were collected. The AMH values were measured using the revised Gen II assay. We established and validated 5 AMH-age regression models. Based on the optimal AMH-age model, reference values and centile charts were obtained. The quadratic model (${\log}\;AMH=0.410{\times}age-0.008{\times}age^2-3.791$) was the most appropriate for describing the age-dependent decrease in AMH measured using the revised Gen II assay. This is the largest population-based study to establish age-specific reference values of AMH using the revised Gen II assay. These reference values may provide more specific information regarding the ovarian reserve estimation of infertile women.

Keywords

Acknowledgement

Supported by : Ministry of Health and Welfare

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