The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
권호 표지
DOI QR코드

DOI QR Code

An Overview of the Applicability of Oryung-san as an Antihypertensive Agent

오령산의 고혈압 치료약물 가능성에 대한 개관

  • Jeong, Min-jeong (Dept. of Pediatrics, College of Korean Medicine, Woo-Suk University) ;
  • Kang, Ki-wan (Dept. of Internal Medicine, College of Korean Medicine, Woo-Suk University) ;
  • Kang, Ja-yeon (Dept. of Internal Medicine, College of Korean Medicine, Woo-Suk University) ;
  • Yoon, Jee-hyun (Dept. of Herbology, College of Korean Medicine, Woo-Suk University) ;
  • Choi, Yoo-min (Dept. of Acupuncture, College of Korean Medicine, Woo-Suk University) ;
  • Kim, Hong-jun (Dept. of Prescription, College of Korean Medicine, Woo-Suk University) ;
  • Sun, Seung-ho (Dept. of Internal Medicine, College of Korean Medicine, Sang-Ji University) ;
  • Jang, In-soo (Dept. of Internal Medicine, College of Korean Medicine, Woo-Suk University)
  • 정민정 (우석대학교 한의과대학 소아과학교실) ;
  • 강기완 (우석대학교 한의과대학 한방내과학교실) ;
  • 강자연 (우석대학교 한의과대학 한방내과학교실) ;
  • 윤지현 (우석대학교 한의과대학 본초학교실) ;
  • 최유민 (우석대학교 한의과대학 침구학교실) ;
  • 김홍준 (우석대학교 한의과대학 방제학교실) ;
  • 선승호 (상지대학교 한의과대학 한방내과학교실) ;
  • 장인수 (우석대학교 한의과대학 한방내과학교실)
  • Received : 2017.09.06
  • Accepted : 2017.09.25
  • Published : 2017.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives: This study assessed the application of Oryung-san (Wuling-san or Gorei-san), a common diuretic in traditional medicine, as an antihypertensive agent. Methods: Experimental studies of the pharmacological properties of Oryung-san, including diuretic action and lowering effects on blood pressure, and toxicology and clinical trials were reviewed. Results: In pharmacology, various, relatively safe diuretics are used to lower blood pressure and are the oldest and most studied antihypertensive agents. Despite many new drug approvals, antihypertensive diuretics are frequently used in Korea and Japan where high levels of sodium uptake are common. Oryung-san has been demonstrated to have diuretic, antihypertensive, and nephroprotective effects. Conclusions: Oryung-san might be effective for lowering blood pressure based on the results of this literature review. Further evaluations and large-scale clinical trials of Oryung-san to treat primary hypertension are warranted.

Keywords

References

  1. Choi SW, Han SW, Ok JS, Yoo BS, Shin MS, Park SH, et al. A multicenter cohort study of primary hypertension in Korea: study design and interim analysis of the Korean registry of target organ damage in hypertension(KorHR). Clin Hypertens 2017;23(1):16. https://doi.org/10.1186/s40885-017-0072-2
  2. Whelton PK. Epidemiology of hypertension. Lancet 1994;344(8915):101-6. https://doi.org/10.1016/S0140-6736(94)91285-8
  3. Guo X, Zhou B, Nishimura T, Teramukai S, Fukushima M. Clinical effect of qigong practice on essential hypertension: a meta-analysis of randomized controlled trials. Journal of alternative and complementary medicine. J Altern Complement Med 2008;14(1):27-37. https://doi.org/10.1089/acm.2007.7213
  4. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, et al. The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report. JAMA 2003;289(19):2560-72. https://doi.org/10.1001/jama.289.19.2560
  5. Shin J, Park JB, Kim KI, Kim JH, Yang DH, Pyun WB, et al. 2013 Korean Society of Hypertension guidelines for the management of hypertension: part I-epidemiology and diagnosis of hypertension. Clin Hypertens 2015;21:1. https://doi.org/10.1186/s40885-014-0012-3
  6. Kim HC, Oh SM. Noncommunicable diseases: current status of major modifiable risk factors in Korea. J Prev Med Public Health 2013;46(4):165-72. https://doi.org/10.3961/jpmph.2013.46.4.165
  7. KPMA. Pharmaceutical Industry Data Book. 2016. [accessed 2017 Aug. 25] URL=http://www.kpma.or.kr/attach/1611_KPMA%20DATA%20BOOK_ver1.pdf
  8. E-Daily News. Development of hypertension drug '3 in 1 combination'. [accessed 2017 Aug. 25] URL=http://www.edaily.co.kr/news/NewsRead.edy?SCD=JC61&newsid=01341526612814560&DCD=A00306&OutLnkChk=Y
  9. Health Insurance review & assessment service. Medical Statistics Index. 2015. [accessed 2017 Aug. 25] URL=https://www.khiss.go.kr/board/bbs_read.jsp?tname=MINBOARD358&bbsid=B301&cat_bbsid=&bbs_seq=434&jkey=&jword=&pg=4&htxt_code=12536978062659050219061516896964&wj_vcs=&reverseNum=182&forwardNum=31
  10. Korean Academy of Medical Sciences. Evidence-based Guideline for Hypertension in Primary Care. 2014. [accessed 2017 Aug. 25] URL=http://www.guideline.or.kr
  11. The education committee of Korean medicine college for Herbal formula science. Herbal formula science. Seoul: Yeonglimsa; 2003, p. 504-6.
  12. Zhao YY, Xie RM, Chao X, Zhang Y, Lin RC, Sun WJ. Bioactivity-directed identification of diuretic compounds from Polyporus umbellatus. J Ethropharmacol 2009;126(1):184-7. https://doi.org/10.1016/j.jep.2009.07.033
  13. Yuan D, Mori J, Komatsu KI, Makino T, Kano Y. An anti-aldosteronic diuretic component(drain dampness) in Polyporus sclerotium. Biol Pharm Bull 2004;27(6):867-70. https://doi.org/10.1248/bpb.27.867
  14. Zhu YP. Chinese Materia Medica Chemistry: Pharmacology and Applications. Amsterdam: Harwood Academic Publishers; 1998, p. 501-2.
  15. Wu ZL, Ren H, Lai WY, Lin S, Jiang RY, Ye TC, et al. Sclederma of Poria cocos exerts its diuretic effect via suppression of renal aquaporin-2 expression in rats with chronic heart failure. J Ethropharmacol 2014;155(1):563-71. https://doi.org/10.1016/j.jep.2014.05.054
  16. Feng YL, Chen H, Tian T, Chen DQ, Zhao YY, Lin RC. Diuretic and anti-diuretic activities of the ethanol and aqueous extracts of Alismatis rhizoma. J Ethropharmacol 2014;154(2):386-90. https://doi.org/10.1016/j.jep.2014.04.017
  17. Chen DQ, Feng YL, Tian T, Chen H, Yin L, Zhao YY, et al. Diuretic and anti-diuretic activities of fractions of Alismatis rhizoma. J Ethropharmacol 2014;157:114-8. https://doi.org/10.1016/j.jep.2014.09.022
  18. Hattori T, Nishimura H, Makino B, Shindo S, Kawamura H. Sairei-to inhibits the production of endothelin-1 by nephritic glomeruli (2): alisols, possible candidates as active compounds. Nihon Jinzo Gakkai Shi 1998;40(2):33-41.
  19. Satoh K, Yasuda I, Nagai F, Ushiyama K, Akiyama K, Kano I. The effects of crude drugs using diuretic on horse kidney (Na++K+)-adenosine triphosphatase. Yakugaku Zasshi 1991;111(2):138-45. https://doi.org/10.1248/yakushi1947.111.2_138
  20. Lee SI. Studies on the diuretic action of Oryeongsan and Kami-Oryeongsan. Kor J Pharmacog 1981;12(1):31-43.
  21. Ahn YM. Oryeongsan has different effects on water and electrolyte balance by routes of administration. Master's Thesis, Wonkwang University 2011:58.
  22. Ahn YM, Cho KW, Kang DG, Lee HS. Oryeongsan (Wulingsan), a traditional Chinese herbal medicine, induces natriuresis and diuresis along with an inhibition of the renin-angiotensin-aldosterone system in rats. J Ethnopharmacol 2012;141:780-5. https://doi.org/10.1016/j.jep.2012.02.021
  23. Kim KA, Min YK, Lee HS, Ryu DG. Effects of the gastric administration of Oryungsan water extract on the renal function, plasma renin activity and plasma levels of atrial natriuretic peptide in the rats. J Oriental Physiology 1996;11(2):89-98.
  24. Kurita T, Nakamura K, Tabuchi M, Orita M, Ooshima K, Higashino H. Effects of Gorei-san: a traditional Japanese Kampo medicine, on aquaporin 1, 2, 3, 4 and V2R mRNA expression in rat kidney and forebrain. J Med Sci 2011;11(1):30-8. https://doi.org/10.3923/jms.2011.30.38
  25. Ahn YM. Effects of Oryeongsan on Regulation of Renal Function and Hormonal Balance in Hypertensive Rats. Ph.D. Thesis, Wonkwang University 2016:82.
  26. Han YP, Wang NS, Mi SQ, Liu QD. Effect of Wuling powder on rats with renal hypertension. Zhong Xi Yi Jie He Xue Bao 2003;1(4):285-8. https://doi.org/10.3736/jcim20030417
  27. Cho DH, Doo HK, Kim IS, Sohn SY, Chung YH, Han YH, et al. Effects of Gamioryeongsan, Gamiyukmijihwangtang and vinegar on rats with acute renal failure induced by gentamicin sulfate. J Kyung Hee Univ 1991;7(3):287-311.
  28. Ahn SY. Effects of Oryeongsan and Yukmijihwangtang on rats with acute renal failure induced by gentamicin sulfate. Master's Thesis, Kyunghee University 1993:59.
  29. Lee MG. Effects of Paljungsan and Kamioryungsan on rats with acute renal failure induced by gentamicin sulfate. Master's Thesis, Kyunghee University 1997:43.
  30. Tsumura & Co. Tsumura Goreisan extract granules for ethical use. Revised: May 2007(4th version) [accessed 2017 Aug. 25] URL=http://www.tsumura.co.jp/english/products/pi/JPR_T017.pdf
  31. Park H, Hwang Y, Ha J, Jung K, Ma J. Acute Toxicity Study on Oryeong-san in Mice. Herbal Fomula Science 2013;21(1):111-8. https://doi.org/10.14374/HFS.2013.21.1.111
  32. Zhang Y, Wang N, Liu Q, YE S, OU W. Evaluation of Toxicity of WLS. Chinese Journal of Modern Drug Application 2008;2(12):16-8.
  33. Lee H, Kang K, Lee E, Lee S, Han C, Jang I. A Systematic Review on Antihypertensive Effects of Oryeong-san. Korean J Orient Int Med 2013;34(3):289-97.
  34. Peon X, Cheng X, Sung R, Kong B. Clinical observation on 80 cases of primary hypertension treated by Amlodipine and Danqi Wuling powder. Yunnan Journal of Traditional Chinese Medicine and Materia Medica 2011;32(9):23-4.
  35. Quan Y. Investigation of renal protective effect in early hypertensive renal injury by supplemented Wuling San combined with Liuweidihuang decoction. Capital Medicine 2011;(08):44-6.
  36. Fan Y. Clinical research on treatment of Wuling power on metabolic syndrome. Guangzhou University of Chinese Medicine 2012:1-50.
  37. Jang I, Kim M, Han H, Jeong M, Kang S. Treatment of primary hypertension by Oryung-san monotherapy: a case report. J Internal Korean Med 2014;35(1):106-10.
  38. Jeon U. Principles and Practice of Diuretic Therapy. Korean J Med 2011;80(1):8-14.
  39. Ding XQ, Pan Y, Wang X, Ma YX, Kong LD. Wuling San ameliorates urate under-excretion and renal dysfunction in hyperuricemic mice. Chin J Nat Med 2013;11(3):214-21. https://doi.org/10.1016/S1875-5364(13)60019-9
  40. Yang Y, Zhang DM, Liu JH, Hu LS, Xue QC, Ding XQ, et al. Wuling San protects kidney dysfunction by inhibiting renal TLR4/MyD88 signaling and NLRP3 inflammasome activation in high fructose-induced hyperuricemic mice. J Ethnopharmacol 2015;169:49-59. https://doi.org/10.1016/j.jep.2015.04.011
  41. Takei H, Nakai Y, Hattori N, Yamamoto M, Takeda S, Yamamoto M, et al. The herbal medicines Saireito and Boiogito improve the hypertension of pre-eclamptic rats induced by Nomega-Nitro-L-arginine methyl ester. Phytomedicine 2007;14:591-600. https://doi.org/10.1016/j.phymed.2007.01.009
  42. Qiu Y, Yu F, Zhang W, Zhou M. Clinical observation on effect of Wuling powder on electrolyte in patients with nephrotic syndrome. CJGMCM 2016;31(18):2665-8.
  43. Kim SY. Influence of Goryeosin infusion solution on the change of serum electrolytes in rats. Dajeon Univ 1990:1-38.
  44. Ito Y. Pathophysiology of the Goreisan show lowering of osmolality set point. Japanese Journal of Oriental Medicine 1978;28:91-9.
  45. Isohama Y. Modulation of aquaporin water channel function by Kampo medicines. Kampo and the newest therapy 2008;17:27-35.
  46. Sakamoto A, Kuriyama K, Konoshita Y, Hodaka K, Kainuma M. A case of hyponatremia complicated with small cell lung cancer successfully treated with Goreisan. Kampo Med 2015;66(2):124-30. https://doi.org/10.3937/kampomed.66.124
  47. The education committee of Korean medicine college for cardiology and neurology. The cardiology and neurology in Korean medicine Vol. 2. Seoul: Woori medical books; 2016, p. 196-8, 366-75.
  48. The Korean society of hypertension. Hypertension management guidelines. [accessed 2017 Aug. 25] URL=http://www.koreanhypertension.org
  49. Chae S. Is diuretics the top priority? Cardiovascular Update 2003;5(3):11-5.

Cited by

  1. 혈부축어탕의 본태성 고혈압에 대한 치료 효과 관한 메타 분석 및 체계적 고찰 vol.39, pp.6, 2017, https://doi.org/10.22246/jikm.2018.39.6.1150
  2. 성형 수술 후 부종에서 호박탕(琥珀湯)의 효과 : 2 증례보고 vol.33, pp.1, 2020, https://doi.org/10.6114/jkood.2020.33.1.083