Biomedical Science Letters (대한의생명과학회지)

The Korean Society for Biomedical Laboratory Sciences (대한의생명과학회)
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Enhanced Anti-cancer Efficacy in MCF-7 Breast Cancer Cells by Combined Drugs of Metformin and Sodium Salicylate

  • Kim, Yun-Ji (Department of Biomedical Laboratory Science, Konyang University) ;
  • Park, Hee-Bin (Department of Biomedical Laboratory Science, Konyang University) ;
  • Kim, Pyung-Hwan (Department of Biomedical Laboratory Science, Konyang University) ;
  • Park, James S. (Department of Medicine, New York University School of Medicine) ;
  • Kim, Keun-Sik (Department of Biomedical Laboratory Science, Konyang University)
  • Received : 2017.07.04
  • Accepted : 2017.07.11
  • Published : 2017.09.30
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Abstract

Metformin or sodium salicylate is known to induce apoptosis and G0/G1 phase arrest in a variety of cancer cells. However, the anti-cancer effects of the combined treatments for these drugs-induced apoptosis are yet unclear. Here, we found that the combined treatment of metformin and sodium salicylate increased the efficacy of chemotherapeutics against breast cancer cells. These combined drugs significantly inhibited cellular proliferation and induced apoptosis at an earlier stage in human MCF-7 breast cancer cells. Also, co-treatments of metformin and sodium salicylate induced G1 cell cycle arrest in MCF-7 cells more effectively than either agent alone. Taken together, these results demonstrate that dual metformin/sodium salicylate treatment prevents proliferation of MCF-7 cells by inducing apoptosis and G1 cell cycle arrest.

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References

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