Biomedical Science Letters (대한의생명과학회지)

The Korean Society for Biomedical Laboratory Sciences (대한의생명과학회)
권호 표지
DOI QR코드

DOI QR Code

Ixeris dentata (Thunb) Nakai Attenuates Cognitive Impairment in Scopolamine-induced Amnesic Mice

  • Lee, Sung-Gyu (Department of Medical Laboratory Science, Dankook University) ;
  • Kim, Ki-Whan (Department of R&D Center, C.L.Pharm CO., Ltd.) ;
  • Kang, Hyun (Department of Medical Laboratory Science, Dankook University)
  • Received : 2017.09.12
  • Accepted : 2017.09.26
  • Published : 2017.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

The purpose of the current study is to investigate the cognition-enhancing effects of Ixeris dentata (Thunb) Nakai in scopolamine-induced amnesic mice. Scopolamine (2 mg/kg, i.p.) was used to induce amnesia in mice. The cognitive-enhancing activity of the IDE (10, 20 and $40{\mu}g/mL$) was studied by passive avoidance response, elevated plus maze and Y-maze behavioral paradigm in normal and scopolamine-induced amnesic mice. Scopolamine-induced cognitive deficits were significantly reversed by IDE (P < 0.001 at 20 mg/kg) in a dose-dependent fashion in all the behavioral paradigms tested. IDE possesses cognitive-enhancing properties in amnesic mice due to its potent antioxidant action.

Keywords

References

  1. Ahn E, Bang M, Song M. Cytotoxic and ACAT inhibitory sesquiterpene lactones fromthe root of Ixeris dentata forma albiflora. Archives of Pharmacal Research. 2006. 29: 937-941. https://doi.org/10.1007/BF02969274
  2. Asuntha G, Prasannaraju Y, Prasad KVSRG. Effect of ethanol extract of Indigofera tinctoria Linn. (Fabaceae) on lithium/pilocarpine-induced status epilepticus and oxidative stress in Wistar rats. Tropical Journal of Pharmaceutical Research. 2010. 9: 149-156.
  3. Blum D, Torch S, Lambeng N. "Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease", Progress in Neurobiology. 2001. 65: 135-172. https://doi.org/10.1016/S0301-0082(01)00003-X
  4. Cha MR, Choi YH, Choi CW, Yoo DS, Kim YS, Choi SU. New guaiane sesquiterpene lactones from Ixeris dentata. Planta Medica. 2011. 77: 380-382. https://doi.org/10.1055/s-0030-1250369
  5. Choi JS, Chung HY, Young HS. A preliminary study on hypocholesterolemic and hypoglycemic activities of some medical plants. Korean Journal of Pharmacognosy. 1990. 21: 153-155.
  6. Derrell C. Guide for the care and use of laboratory animals. Institute of laboratory animal resources. National Academy Press. 1996.
  7. El-Sherbiny DA, Khalifa AE, Attia AS, Eldenshery ED. Hypericum perforatum extract demonstrates antioxidant properties against elevated rat brain oxidative status induced by amnestic dose of scopolamine. Pharmacology Biochemistry and Behavior. 2003. 76: 525-533. https://doi.org/10.1016/j.pbb.2003.09.014
  8. Hong S, Jeong D, Kim K, Hwang E. The Composition of the root of Ixeris dentata var. albiflora Nakai. and cell viability and DPPH radical scavenging activities of its extract. Korean Journal of Nutrition. 2010. 43: 105-113. https://doi.org/10.4163/kjn.2010.43.2.105
  9. Im HI, Lee ES, Hwang YJ, Kim YS. Baicalein protects 6-OHDAinduced neuronal damage by suppressing oxidative stress. The Korean Journal of Physiology and Pharmacology. 2006. 10: 309-315.
  10. Kang H. Anti-neuroinflammatory effects of Ixeris dentata Nakai against lipopolysaccharide-induced BV-2 microglial cells via suppressing NF-${\kappa}B$ Signaling. Tropical Journal of Pharmaceutical Research. 2014. 13: 1629-1635. https://doi.org/10.4314/tjpr.v13i10.9
  11. Kasture SB, Kasture VS, Joshua AJ. Damodaran A, Amit A. Nootropic activity of $BacoMind^{TM}$, an enriched phytochemical composition from Bacopamonnieri. Journal of Natural Remedies. 2007. 7: 166-173.
  12. Kim DS, Ko JH, Jeon YD, Han YH, Kim HJ, Poudel A. Ixeris dentata NAKAI reduces clinical score and HIF-1 expression in experimental colitis in mice. Evidence-Based Complementary and Alternative Medicine. 2013. 67: 1281-1289.
  13. Kim MJ, Kim JS, Jeong DM, Ham SS, Yu CY. Effect of antioxidant, antimutagenicity and anticancer of root extract from Ixeris dentata Nakai. Korean Journal of Medicinal Crop Science. 2002. 10: 222-229.
  14. Kim SB, Kang OH, Joung DK, Mun SH, Seo YS, Cha MR. Antiinflammatory effects of tectroside on UVB induced HaCaT cells. International Journal of Molecular Medicine. 2013. 31:1471-1476. https://doi.org/10.3892/ijmm.2013.1343
  15. Kumar H, Kim BW, Song SY, Kim JS, Kim IS, Kwon YS, Koppula S, Choi DK. Cognitive enhancing effects of alpha asarone in amnesic mice by influencing cholinergic and antioxidant defense mechanisms. Bioscience, Biotechnology, and Biochemistry. 2012. 76: 1518-1522. https://doi.org/10.1271/bbb.120247
  16. Lee SK, Kang H. Ixeris dentata (Thunb) Nakai Ethylacetate extract attenuates sterol regulatory element-binding proteins-1c via AMP-activated protein kinase activation. Tropical Journal of Pharmaceutical Research. 2016. 15: 453-459. https://doi.org/10.4314/tjpr.v15i3.4
  17. Moon M, Kim HG, Hwang L, Seo JH, Kim S, Hwang S, Kim S, Lee D, Chung H, Oh MS, Lee KT, Park. Neuroprotective effect of ghrelin in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease by blocking microglial activation. Neurotoxicity Research. 2009. 15: 332-347. https://doi.org/10.1007/s12640-009-9037-x
  18. Satyanarayana S, Sushruta K, Sarma GS, Srinivas N, Subba Raju GV. Antioxidant activity of the aqueous extracts of spicy food additives--evaluation and comparison with ascorbic acid in in-vitro systems. Journal of Herbal Pharmacotherapy. 2004. 4: 1-10.