Development and Reproduction (한국발생생물학회지:발생과생식)

The Korean Society of Developmental Biology (한국발생생물학회)
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Anti-diabetic Effects of Ethanol Extract from Bitter Melon in Mice Fed a High-fat Diet

  • Yoon, Nal Ae (Dept. of Anatomy & Convergence Medical Science, College of Medicine, Gyeongsang National University) ;
  • Park, Juyeong (Dept. of Anatomy & Convergence Medical Science, College of Medicine, Gyeongsang National University) ;
  • Lee, Jiyeon (Dept. of Anatomy & Convergence Medical Science, College of Medicine, Gyeongsang National University) ;
  • Jeong, Joo Yeon (Dept. of Anatomy & Convergence Medical Science, College of Medicine, Gyeongsang National University) ;
  • Kim, Hyun-Kyu (Nutraceutical Food R&D Center, KolmarBNH Co., Ltd.) ;
  • Lee, Hak Sung (Nutraceutical Food R&D Center, KolmarBNH Co., Ltd.) ;
  • Hwang, In Guk (Dept. of Agrofood Resources, National Academy of Agricultural Science, Rural Development Administration) ;
  • Roh, Gu Seob (Dept. of Anatomy & Convergence Medical Science, College of Medicine, Gyeongsang National University) ;
  • Kim, Hyun Joon (Dept. of Anatomy & Convergence Medical Science, College of Medicine, Gyeongsang National University) ;
  • Cho, Gyeong Jae (Dept. of Anatomy & Convergence Medical Science, College of Medicine, Gyeongsang National University) ;
  • Choi, Wan Sung (Dept. of Anatomy & Convergence Medical Science, College of Medicine, Gyeongsang National University) ;
  • Lee, Dong Hoon (Dept. of Anatomy & Convergence Medical Science, College of Medicine, Gyeongsang National University) ;
  • Kang, Sang Soo (Dept. of Anatomy & Convergence Medical Science, College of Medicine, Gyeongsang National University)
  • Received : 2017.09.11
  • Accepted : 2017.09.17
  • Published : 2017.09.30
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Abstract

Present study aimed to determine the effect of 'bitter melon', a popularly used fruit in Bangladesh and several other Asian countries, on high-fat-diet-induced type 2 diabetes. To investigate the effect, ethanol extract from bitter melon (BME) as a dietary supplement with mouse chow was used. BME was found to significantly attenuate the high-fat diet (HFD) -induced body weight and total fat mass. BME also effectively reduced the insulin resistance induced by the HFD. Furthermore, dietary supplementation of BME was highly effective in increasing insulin sensitivity and reducing hepatic fat and obesity. These results indicate that BME could be effective in attenuating type 2 diabetes and could therefore be a preventive measure against type 2 diabetes.

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References

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