Nutrition Research and Practice

The Korean Nutrition Society (한국영양학회)
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Corn silk extract improves benign prostatic hyperplasia in experimental rat model

  • Kim, So Ra (Department of Food Science and Nutrition, Dankook University) ;
  • Ha, Ae Wha (Department of Food Science and Nutrition, Natural Nutraceuticals Industrization Research Center, DanKook University) ;
  • Choi, Hyun Ji (Department of Food Science and Nutrition, Dankook University) ;
  • Kim, Sun Lim (Crop Foundation Division National Institute of Crop Science, RDA) ;
  • Kang, Hyeon Jung (Crop Post-harvest Technology Division, National Institute of Crop Science, RDA) ;
  • Kim, Myung Hwan (Department of Food Engineering, Dankook University) ;
  • Kim, Woo Kyoung (Department of Food Science and Nutrition, Dankook University)
  • Received : 2017.05.02
  • Accepted : 2017.06.23
  • Published : 2017.10.02
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Abstract

BACKGROUND/OBJECTIVES: This study was conducted to investigate the effect of a corn silk extract on improving benign prostatic hyperplasia (BPH). MATERIALS/METHODS: The experimental animals, 6-week-old male Wistar rats, were divided into sham-operated control (Sham) and experimental groups. The experimental group, which underwent orchiectomy and received subcutaneous injection of 10 mg/kg of testosterone propionate to induce BPH, was divided into a Testo Only group that received only testosterone, a Testo+Fina group that received testosterone and 5 mg/kg finasteride, a Testo+CSE10 group that received testosterone and 10 mg/kg of corn silk extract, and a Testo+CSE100 group that received testosterone and 100 mg/kg of corn silk extract. Prostate weight and concentrations of dihydrotestosterone (DHT), $5{\alpha}$- reductase $2(5{\alpha}-R2)$, and prostate specific antigen (PSA) in serum or prostate tissue were determined. The mRNA expressions of $(5{\alpha}-R2)$ and proliferating cell nuclear antigen (PCNA) in prostate tissue were also measured. RESULTS: Compared to the Sham group, prostate weight was significantly higher in the Testo Only group and decreased significantly in the Testo+Fina, Testo+CSE10, and Testo+CSE100 groups (P < 0.05), results that were consistent with those for serum DHT concentrations. The concentrations of $(5{\alpha}-R2)$ in serum and prostate as well as the mRNA expression of $(5{\alpha}-R2)$ in prostate were significantly lower in the Testo+Fina, Testo+CSE10, and Testo+CSE100 groups than that in the Testo Only group (P < 0.05). Similarly, the concentrations of PSA in serum and prostate were significantly lower in the Testo+Fina, Testo+CSE10, and Testo+CSE100 groups (P < 0.05) than in the Testo Only group. The mRNA expression of PCNA in prostate dose-independently decreased in the Testo+CSE-treated groups (P < 0.05). CONCLUSIONS: BPH was induced through injection of testosterone, and corn silk extract treatment improved BPH symptoms by inhibiting the mRNA expression of $(5{\alpha}-R2)$ and decreasing the amount of $(5{\alpha}-R2)$, DHT, and PSA in serum and prostate tissue.

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References

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