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Hepatotoxicity and nephrotoxicity of saponin-enriched extract of Asparagus cochinchinensis in ICR mice

  • Sung, Ji Eun (College of Natural Resources and Life Science/Life and Industry Convergence Research Institute, Pusan National University) ;
  • Choi, Jun Young (College of Natural Resources and Life Science/Life and Industry Convergence Research Institute, Pusan National University) ;
  • Kim, Ji Eun (College of Natural Resources and Life Science/Life and Industry Convergence Research Institute, Pusan National University) ;
  • Lee, Hyun Ah (College of Natural Resources and Life Science/Life and Industry Convergence Research Institute, Pusan National University) ;
  • Yun, Woo Bin (College of Natural Resources and Life Science/Life and Industry Convergence Research Institute, Pusan National University) ;
  • Park, Jin Ju (College of Natural Resources and Life Science/Life and Industry Convergence Research Institute, Pusan National University) ;
  • Kim, Hye Ryeong (College of Natural Resources and Life Science/Life and Industry Convergence Research Institute, Pusan National University) ;
  • Song, Bo Ram (College of Natural Resources and Life Science/Life and Industry Convergence Research Institute, Pusan National University) ;
  • Kim, Dong Seob (College of Natural Resources and Life Science/Life and Industry Convergence Research Institute, Pusan National University) ;
  • Lee, Chung Yeoul (Gangrim Organics) ;
  • Lee, Hee Seob (College of Human Ecology, Pusan National University) ;
  • Lim, Yong (Department of Clinical Laboratory Science, College of Nursing and Healthcare Science, Dong-Eui University) ;
  • Hwang, Dae Youn (College of Natural Resources and Life Science/Life and Industry Convergence Research Institute, Pusan National University)
  • 투고 : 2016.12.12
  • 심사 : 2017.03.16
  • 발행 : 2017.06.30

초록

The inhibitory effects of Asparagus cochinchinensis against inflammatory response induced by lipopolysaccharide (LPS), substance P and phthalic anhydride (PA) treatment were recently reported for some cell lines and animal models. To evaluate the hepatotoxicity and nephrotoxicity of A. cochinchinensis toward the livers and kidneys of ICR mice, alterations in related markers including body weight, organ weight, urine composition, liver pathology and kidney pathology were analyzed in male and female ICR mice after oral administration of 150, 300 and 600 mg/kg body weight/day saponin-enriched extract of A. cochinchinensis (SEAC) for 14 days. The saponin, total flavonoid and total phenol levels were found to be 57.2, 88.5 and 102.1 mg/g in SEAC, respectively, and the scavenging activity of SEAC gradually increased in a dose-dependent manner. Moreover, body and organ weight, clinical phenotypes, urine parameters and mice mortality did not differ between the vehicle and SEAC treated group. Furthermore, no significant alterations were measured in alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), blood urea nitrogen (BUN) and the serum creatinine (Cr) in the SEAC treated group relative to the vehicle treated group. Moreover, the specific pathological features induced by most toxic compounds were not observed upon liver and kidney histological analysis. Overall, the results of the present study suggest that SEAC does not induce any specific toxicity in the livers and kidneys of male and female ICR mice at doses of 600 mg/kg body weight/day.

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과제정보

연구 과제 주관 기관 : Korea Institute of Planning Evaluation for Technology of Food, Agriculture, Forestry and Fisheries

피인용 문헌

  1. Toxicological and behavioral study of two potential antibacterial agents:4-chloromercuribenzoic acid and quercetin on Swiss-albino mice vol.43, pp.6, 2017, https://doi.org/10.1080/01480545.2018.1517774