Korean Circulation Journal

  • 제47권5호
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  • Pages.752-761
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  • 2017
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  • 1738-5520(pISSN)
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  • 1738-5555(eISSN)
대한심장학회 (The Korean Society of Cardiology)
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Discordant Relationships between Systemic Inflammatory Markers and Burden of Oxidative Stress in Patients with Atrial Fibrillation

  • Nam, Jong-Ho (Division of Cardiology, Department of Internal Medicine, Yeungnam University Medical Center) ;
  • Park, Kyu-Hwan (Division of Cardiology, Department of Internal Medicine, Yeungnam University Medical Center) ;
  • Lee, Jung-Hee (Division of Cardiology, Department of Internal Medicine, Yeungnam University Medical Center) ;
  • Lee, Chan-Hee (Division of Cardiology, Department of Internal Medicine, Yeungnam University Medical Center) ;
  • Son, Jang-Won (Division of Cardiology, Department of Internal Medicine, Yeungnam University Medical Center) ;
  • Kim, Ung (Division of Cardiology, Department of Internal Medicine, Yeungnam University Medical Center) ;
  • Park, Jong-Seon (Division of Cardiology, Department of Internal Medicine, Yeungnam University Medical Center) ;
  • Shin, Dong-Gu (Division of Cardiology, Department of Internal Medicine, Yeungnam University Medical Center)
  • 투고 : 2017.01.31
  • 심사 : 2017.06.06
  • 발행 : 2017.09.30
⟨ 이전 논문 다음 논문 ⟩

초록

Background and Objectives: Oxidative stress (OS) plays an important role in the pathophysiology of atrial fibrillation (AF) by amplifying the inflammatory cascade, wherein augmented inflammation facilitates the atrial electrical remodeling process. Few studies have investigated the possible link between systemic inflammation and OS in AF. Subjects and Methods: A total of 220 consecutive patients with AF (117 patients) or healthy controls (103 patients) were enrolled. Among the 117 AF patients, 65 paroxysmal AF (PaAF) and 52 persistent AF (PeAF) patients were included. The level of 8-iso-prostaglandin $F2{\alpha}$ ($8-iso-PGF2{\alpha}$) was measured as a marker of OS burden. We evaluated the correlations between 3 systemic inflammatory markers, high-sensitivity C-reactive protein (hsCRP), neutrophil to lymphocyte ratio (NLR), and red cell distribution width (RDW), and $8-iso-PGF2{\alpha}$. Results: The $8-iso-PGF2{\alpha}$ concentration in both PaAF and PeAF patients was higher than that of controls (p<0.001 and p=0.024, respectively). The NLR and RDW of PeAF patients were higher than those of both control and PaAF patients (p=0.041 and p=0.031 for NLR, p=0.057 and p=0.031 for RDW, respectively). There were no correlations between specific inflammatory markers and the $8-iso-PGF2{\alpha}$ in AF. The $8-iso-PGF2{\alpha}$ level decreased gradually with an increase in AF duration (p=0.008), contrary to the graded increase in hsCRP. Multiple regression analysis indicated that AF duration persisted as a significant determinant of $8-iso-PGF2{\alpha}$ (${\beta}=-0.249$, p=0.044). Conclusion: Systemic inflammatory marker levels were not proportional to the levels of $8-iso-PGF2{\alpha}$, an OS marker, in AF.

키워드

참고문헌

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피인용 문헌

  1. Five‐Year Change in the Renal Function After Catheter Ablation of Atrial Fibrillation vol.8, pp.17, 2019, https://doi.org/10.1161/jaha.119.013204
  2. Red blood cell distribution width and atrial fibrillation vol.14, pp.13, 2017, https://doi.org/10.2217/bmm-2020-0041