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Short-Term Change of Exercise Capacity in Patients with Pulmonary Valve Replacement after Tetralogy of Fallot Repair

  • Hwang, Tae Woong (Department of Pediatrics, Sejong General Hospital) ;
  • Kim, Sung Ook (Department of Pediatrics, Sejong General Hospital) ;
  • Kim, Moon Sun (Department of Pediatrics, Sejong General Hospital) ;
  • Jang, So Ick (Department of Pediatrics, Sejong General Hospital) ;
  • Kim, Seong Ho (Department of Pediatrics, Sejong General Hospital) ;
  • Lee, Sang Yun (Department of Pediatrics, Sejong General Hospital) ;
  • Choi, Eun Young (Department of Pediatrics, Sejong General Hospital) ;
  • Park, Su Jin (Department of Pediatrics, Sejong General Hospital) ;
  • Kwon, Hye Won (Department of Pediatrics, Sejong General Hospital) ;
  • Lim, Hyo Bin (Department of Pediatrics, Sejong General Hospital)
  • Received : 2016.06.20
  • Accepted : 2016.10.20
  • Published : 2017.03.31

Abstract

Background and Objectives: The aim of this study was to investigate the effect of pulmonary valve replacement (PVR) on exercise capacity and determine cardiopulmonary exercise (CPEX) parameters associated with improvement in right ventricle (RV) function. Subjects and Methods: We retrospectively analyzed CPEX and magnetic resonance imaging parameters in a total of 245 patients who underwent PVR from January 1998 to October 2015. In addition, we analyzed the characteristics of the patients who showed improved exercise capacity after PVR. Results: Twenty-eight patients met the inclusion criteria for the study. CPEX parameters after PVR showed no significant changes in all patients. However, baseline predicted peak oxygen uptake ($VO2_{peak}$) (%) value was significantly lower in patients with significant improvement in exercise capacity after PVR, as compared to patients who showed decreased exercise capacity after PVR ($60.83{\pm}10.28$ vs. $75.81{\pm}13.83$) (p=0.003). In addition, patients with improved exercise capacity showed a positive correlation between the change of right ventricular ejection fraction (RVEF) (%) and the change of anaerobic threshold (r=0.733, p=0.007); whereas, patients with decreased exercise capacity showed a negative correlation between the change of RVEF (%) and the change of predicted $VO2_{peak}$ (%) (r=-0.575, p=0.020). Conclusion: The importance of predicted $VO2_{peak}$ (%) in evaluating exercise capacity differentiated from other CPEX variables. The change of anaerobic threshold and predicted $VO2_{peak}$ (%) might be a useful predictor of the change in RV function after PVR.

Keywords

References

  1. Bove EL, Byrum CJ, Thomas FD, et al. The influence of pulmonary insufficiency on ventricular function following repair of tetralogy of Fallot. Evaluation using radionuclide ventriculography. J Thorac Cardiovasc Surg 1983;85:691-6.
  2. Katz NM, Blackstone EH, Kirklin JW, Pacifico AD, Bargeron LM Jr. Late survival and symptoms after repair of tetralogy of Fallot. Circulation 1982;65:403-10. https://doi.org/10.1161/01.CIR.65.2.403
  3. Murphy JG, Gersh BJ, Mair DD, et al. Long-term outcome in patients undergoing surgical repair of tetralogy of Fallot. N Engl J Med 1993;329:593-9. https://doi.org/10.1056/NEJM199308263290901
  4. Nollert G, Fischlein T, Bouterwek S, Bohmer C, Klinner W, Reichart B. Long-term survival in patients with repair of tetralogy of Fallot: 36- year follow-up of 490 survivors of the first year after surgical repair. J Am Coll Cardiol 1997;30:1374-83. https://doi.org/10.1016/S0735-1097(97)00318-5
  5. Ilbawi MN, Idriss FS, DeLeon SY, et al. Factors that exaggerate the deleterious effects of pulmonary insufficiency on the right ventricle after tetralogy repair. Surgical implications. J Thorac Cardiovasc Surg 1987;93:36-44.
  6. Bouzas B, Kilner PJ, Gatzoulis MA. Pulmonary regurgitation: not a benign lesion. Eur Heart J 2005;26:433-9. https://doi.org/10.1093/eurheartj/ehi091
  7. Gatzoulis MA, Balaji S, Webber SA, et al. Risk factors for arrhythmia and sudden cardiac death late after repair of tetralogy of Fallot: a multicentre study. Lancet 2000;356:975-81. https://doi.org/10.1016/S0140-6736(00)02714-8
  8. Geva T, Sandweiss BM, Gauvreau K, Lock JE, Powell AJ. Factors associated with impaired clinical status in long-term survivors of tetralogy of Fallot repair evaluated by magnetic resonance imaging. J Am Coll Cardiol 2004;43:1068-74. https://doi.org/10.1016/j.jacc.2003.10.045
  9. Therrien J, Marx GR, Gatzoulis MA. Late problems in tetralogy of Fallot-recognition, management, and prevention. Cardiol Clin 2002;20:395-404. https://doi.org/10.1016/S0733-8651(02)00010-3
  10. Babu-Narayan SV, Diller GP, Gheta RR, et al. Clinical outcomes of surgical pulmonary valve replacement after repair of tetralogy of Fallot and potential prognostic value of preoperative cardiopulmonary exercise testing. Circulation 2014;129:18-27. https://doi.org/10.1161/CIRCULATIONAHA.113.001485
  11. Lee C, Kim YM, Lee CH, et al. Outcomes of pulmonary valve replacement in 170 patients with chronic pulmonary regurgitation after relief of right ventricular outflow tract obstruction: implications for optimal timing of pulmonary valve replacement. J Am Coll Cardiol 2012;60:1005-14. https://doi.org/10.1016/j.jacc.2012.03.077
  12. Frigiola A, Tsang V, Bull C, et al. Biventricular response after pulmonary valve replacement for right ventricular outflow tract dysfunction: is age a predictor of outcome? Circulation 2008;118(14 Suppl):S182-90. https://doi.org/10.1161/CIRCULATIONAHA.107.756825
  13. Lee JS, Jang SI, Kim SH, Lee SY, Baek JS, Shim WS. The results of cardiopulmonary exercise test in healthy Korean children and adolescents: single center study. Korean J Pediatr 2013;56:242-6. https://doi.org/10.3345/kjp.2013.56.6.242
  14. Guazzi M, Adams V, Conraads V, et al. EACPR/AHA Scientific Statement. Clinical recommendations for cardiopulmonary exercise testing data assessment in specific patient populations. Circulation 2012;126:2261-74. https://doi.org/10.1161/CIR.0b013e31826fb946
  15. Matsumura N, Nishijima H, Kojima S, Hashimoto F, Minami M, Yasuda H. Determination of anaerobic threshold for assessment of functional state in patients with chronic heart failure. Circulation 1983;68:360-7. https://doi.org/10.1161/01.CIR.68.2.360
  16. Buechel ER, Dave HH, Kellenberger CJ, et al. Remodelling of the right ventricle after early pulmonary valve replacement in children with repaired tetralogy of Fallot: assessment by cardiovascular magnetic resonance. Eur Heart J 2005;26:2721-7. https://doi.org/10.1093/eurheartj/ehi581
  17. Oechslin EN, Harrison DA, Harris L, et al. Reoperation in adults with repair of tetralogy of fallot: indications and outcomes. J Thorac Cardiovasc Surg 1999;118:245-51. https://doi.org/10.1016/S0022-5223(99)70214-X
  18. Lurz P, Giardini A, Taylor AM, et al. Effect of altering pathologic right ventricular loading conditions by percutaneous pulmonary valve implantation on exercise capacity. Am J Cardiol 2010;105:721-6. https://doi.org/10.1016/j.amjcard.2009.10.054
  19. Batra AS, McElhinney DB, Wang W, et al. Cardiopulmonary exercise function among patients undergoing transcatheter pulmonary valve implantation in the US Melody valve investigational trial. Am Heart J 2012;163:280-7. https://doi.org/10.1016/j.ahj.2011.10.017
  20. Gengsakul A, Harris L, Bradley TJ, et al. The impact of pulmonary valve replacement after tetralogy of Fallot repair: a matched comparison. Eur J Cardiothorac Surg 2007;32:462-8. https://doi.org/10.1016/j.ejcts.2007.06.009
  21. Ghez O, Tsang VT, Frigiola A, et al. Right ventricular outflow tract reconstruction for pulmonary regurgitation after repair of tetralogy of Fallot. Preliminary results. Eur J Cardiothorac Surg 2007;31:654-8. https://doi.org/10.1016/j.ejcts.2006.12.031
  22. Sterrett LE, Ebenroth ES, Query C, et al. Why exercise capacity does not improve after pulmonary valve replacement. Pediatr Cardiol 2014;35:1395-402. https://doi.org/10.1007/s00246-014-0942-2
  23. Oosterhof T, Mulder BJ, Vliegen HW, de Roos A. Cardiovascular magnetic resonance in the follow-up of patients with corrected tetralogy of Fallot: a review. Am Heart J 2006;151:265-72. https://doi.org/10.1016/j.ahj.2005.03.058
  24. Fredriksen PM, Therrien J, Veldtman G, et al. Aerobic capacity in adults with tetralogy of Fallot. Cardiol Young 2002;12:554-9. https://doi.org/10.1017/S1047951102001002
  25. Wasserman K, Hansen JE, Sue DY, Whipp BJ. Principles of exercise testing and interpretation. 2nd ed. Malvern, Philadelphia: Lea & Febiger; 1994. p.64.
  26. LW S. Role of exercise testing in the evaluation of candidates for cardiac transplantation. In: Wasserman K, editor. Exercise gas exchange in heart disease. Armonk, New York: Futura Publishing Company; 1996. p.271-86.
  27. Ivy JL, Withers RT, Van Handel PJ, Elger DH, Costill DL. Muscle respiratory capacity and fiber type as determinants of the lactate threshold. J Appl Physiol Respir Environ Exerc Physiol 1980;48:523-7.
  28. Sullivan MJ, Higginbotham MB, Cobb FR. Exercise training in patients with chronic heart failure delays ventilatory anaerobic threshold and improves submaximal exercise performance. Circulation 1989;79:324-9. https://doi.org/10.1161/01.CIR.79.2.324
  29. Davis JA. Anaerobic threshold: review of the concept and directions for future research. Med Sci Sports Exerc 1985;17:6-21.
  30. Gaultier C, Boule M, Thibert M, Leca F. Resting lung function in children after repair of tetralogy of Fallot. Chest 1986;89:561-7. https://doi.org/10.1378/chest.89.4.561

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